WO2001091736A3 - Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic - Google Patents

Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic Download PDF

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Publication number
WO2001091736A3
WO2001091736A3 PCT/US2001/014793 US0114793W WO0191736A3 WO 2001091736 A3 WO2001091736 A3 WO 2001091736A3 US 0114793 W US0114793 W US 0114793W WO 0191736 A3 WO0191736 A3 WO 0191736A3
Authority
WO
WIPO (PCT)
Prior art keywords
pain
endothelin receptor
combinations
receptor antagonist
alleviating
Prior art date
Application number
PCT/US2001/014793
Other languages
French (fr)
Other versions
WO2001091736A2 (en
Inventor
David James Dooley
Original Assignee
Warner Lambert Co
David James Dooley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, David James Dooley filed Critical Warner Lambert Co
Priority to US10/296,792 priority Critical patent/US20030232787A1/en
Priority to EP01939002A priority patent/EP1289558A2/en
Priority to BR0111207-4A priority patent/BR0111207A/en
Priority to JP2001587752A priority patent/JP2003535061A/en
Priority to AU2001264570A priority patent/AU2001264570A1/en
Priority to CA002409927A priority patent/CA2409927A1/en
Priority to MXPA02010764A priority patent/MXPA02010764A/en
Publication of WO2001091736A2 publication Critical patent/WO2001091736A2/en
Publication of WO2001091736A3 publication Critical patent/WO2001091736A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention is a novel combination effective for alleviating pain comprising a pain alleviating effective amount of an endothelin receptor antagonist or a pharmaceutically acceptable salt thereof and from 1 to 3 compounds independently selected from the group consisting of antiepileptic compounds having pain alleviating properties and analgesics, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising same. The administration of endothelin receptor antagonists in these novel combinations results in an improved reduction in the frequency and severity of pain. The incidence of unwanted side effects can be reduced by these novel combinations in comparison to using higher doses of a single agent treatment to achieve a similar therapeutic effect. The present invention is also directed to methods of using effective amounts of the novel combinations and pharmaceutical compositions thereof to treat pain in mammals, including a human.
PCT/US2001/014793 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic WO2001091736A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/296,792 US20030232787A1 (en) 2001-05-08 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
EP01939002A EP1289558A2 (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
BR0111207-4A BR0111207A (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain relieving or analgesic properties
JP2001587752A JP2003535061A (en) 2000-05-31 2001-05-08 Conjugates of endothelin receptor antagonists and antiepileptic compounds or analgesics with pain-relieving properties
AU2001264570A AU2001264570A1 (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
CA002409927A CA2409927A1 (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
MXPA02010764A MXPA02010764A (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20825900P 2000-05-31 2000-05-31
US60/208,259 2000-05-31

Publications (2)

Publication Number Publication Date
WO2001091736A2 WO2001091736A2 (en) 2001-12-06
WO2001091736A3 true WO2001091736A3 (en) 2002-10-17

Family

ID=22773911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014793 WO2001091736A2 (en) 2000-05-31 2001-05-08 Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic

Country Status (7)

Country Link
EP (1) EP1289558A2 (en)
JP (1) JP2003535061A (en)
AU (1) AU2001264570A1 (en)
BR (1) BR0111207A (en)
CA (1) CA2409927A1 (en)
MX (1) MXPA02010764A (en)
WO (1) WO2001091736A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002049630A2 (en) * 2000-12-21 2002-06-27 Bristol-Myers Squibb Company Method for preventing or treating pain by administering an endothelin antagonist
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
ATE493126T1 (en) 2001-11-01 2011-01-15 Spectrum Pharmaceuticals Inc MEDICAL COMPOSITIONS FOR THE INTRAVESICAL TREATMENT OF BLADDER CANCER
US7973064B2 (en) 2001-11-27 2011-07-05 The Board Of Trustees Of The University Of Illinois Method and composition for potentiating an opiate analgesic
DK1478366T3 (en) * 2002-02-19 2009-03-30 Adcock Ingram Ltd Pharmaceutical combinations of meloxicam, codeine phosphate and paracetamol
US7351692B2 (en) * 2002-06-19 2008-04-01 The Board Of Trustees Of The University Of Illinois Method and composition for potentiating the antipyretic action of a nonopioid analgesic
GB0219660D0 (en) 2002-08-23 2002-10-02 Astrazeneca Ab Therapeutic use
AU2003286647B2 (en) 2002-10-24 2009-11-05 The Board Of Trustees Of The University Of Illinois Method and composition for preventing and treating solid tumors
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
CA2661833C (en) 2006-08-31 2016-01-26 Spectrum Pharmaceuticals, Inc. Sensitization of tumor cells to radiation therapy through the administration of endothelin agonists
US7645767B2 (en) 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
KR100842351B1 (en) * 2007-01-04 2008-06-30 한국생명공학연구원 Pharmaceutical composition for the prevention and treatment of cancers containing indole derivatives as an active ingredient
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma
US9447025B2 (en) 2013-03-14 2016-09-20 Kalyra Pharmaceuticals, Inc. Bicyclic analgesic compounds
JP6539274B2 (en) 2013-08-12 2019-07-03 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド Extruded immediate release abuse deterrent pills
JP2016531874A (en) 2013-09-26 2016-10-13 ファーマケア，インク． Autotaxin inhibitor compounds
JP6542794B2 (en) 2013-12-12 2019-07-10 ゼノ ロイアルティー アンド マイルストーンズ リミテッド ライアビリティー カンパニー Bicyclic alkyl compounds, and synthesis
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
KR102401840B1 (en) 2014-03-07 2022-05-25 리커리엄 아이피 홀딩스, 엘엘씨 Propellane derivates and synthesis
JP6371463B2 (en) 2014-07-17 2018-08-08 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド Immediate release abuse deterrent liquid filler form
CA2961605C (en) 2014-09-17 2023-01-10 Kalyra Pharmaceuticals, Inc. Bicyclic compounds
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
WO2017160926A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
NZ759268A (en) 2017-05-15 2022-07-01 Recurium Ip Holdings Llc Bicyclo[1.1.1]pentyl compounds as analgesics
WO2019199979A1 (en) 2018-04-10 2019-10-17 The General Hospital Corporation Antibacterial compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009818A1 (en) * 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
WO1996026195A1 (en) * 1995-02-21 1996-08-29 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
WO1999012916A1 (en) * 1997-09-05 1999-03-18 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009818A1 (en) * 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
WO1996026195A1 (en) * 1995-02-21 1996-08-29 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
WO1999012916A1 (en) * 1997-09-05 1999-03-18 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Also Published As

Publication number Publication date
BR0111207A (en) 2003-04-01
CA2409927A1 (en) 2001-12-06
JP2003535061A (en) 2003-11-25
WO2001091736A2 (en) 2001-12-06
EP1289558A2 (en) 2003-03-12
AU2001264570A1 (en) 2001-12-11
MXPA02010764A (en) 2003-03-10

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