WO2001090361A3 - Modulation of inflammation by protease-treated mcp-3 chemokine - Google Patents

Modulation of inflammation by protease-treated mcp-3 chemokine Download PDF

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Publication number
WO2001090361A3
WO2001090361A3 PCT/CA2001/000741 CA0100741W WO0190361A3 WO 2001090361 A3 WO2001090361 A3 WO 2001090361A3 CA 0100741 W CA0100741 W CA 0100741W WO 0190361 A3 WO0190361 A3 WO 0190361A3
Authority
WO
WIPO (PCT)
Prior art keywords
host
present
methods
inflammation
effective amount
Prior art date
Application number
PCT/CA2001/000741
Other languages
French (fr)
Other versions
WO2001090361A2 (en
Inventor
G Angus Mcquibban
Ian Clark-Lewis
Original Assignee
Univ British Columbia
Overall Christopher Mark
G Angus Mcquibban
Ian Clark-Lewis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2307705 external-priority patent/CA2307705A1/en
Application filed by Univ British Columbia, Overall Christopher Mark, G Angus Mcquibban, Ian Clark-Lewis filed Critical Univ British Columbia
Priority to AU2001261971A priority Critical patent/AU2001261971A1/en
Publication of WO2001090361A2 publication Critical patent/WO2001090361A2/en
Publication of WO2001090361A3 publication Critical patent/WO2001090361A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides methods of inhibiting the biological activity or the in vivo biological activity of CC-chemokines (including native MCP-3), such as methods of inhibiting inflammation, comprising administering to a host an effective amount of a CC-chemokine receptor antagonist of the present invention. In some embodiments, the invention may provide methods of modulating an immune response in a host, or treating inflammation or autoimmune disease in a host suffering from such diseases, comprising administering to the host an effective amount of a CC-chemokine receptor antagonist of the present invention. Another aspect of the present invention is directed to pharmaceutical compositions comprising an antagonistically effective amount of a CC-chemokine receptor antagonist of the present invention and a pharmaceutically acceptable carrier. In alternative aspects, the invention provides compounds and methods for cancer treatment that facilitate an effective immune response.
PCT/CA2001/000741 2000-05-26 2001-05-25 Modulation of inflammation by protease-treated mcp-3 chemokine WO2001090361A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261971A AU2001261971A1 (en) 2000-05-26 2001-05-25 Modulation of inflammation by protease-treated mcp-3 chemokine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,307,705 2000-05-26
CA 2307705 CA2307705A1 (en) 2000-05-26 2000-05-26 Modulation of inflammation by protease products
CA002316405A CA2316405A1 (en) 2000-05-26 2000-08-17 Modulation of inflammation by protease products
CA2,316,405 2000-08-17

Publications (2)

Publication Number Publication Date
WO2001090361A2 WO2001090361A2 (en) 2001-11-29
WO2001090361A3 true WO2001090361A3 (en) 2002-08-08

Family

ID=25681785

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000741 WO2001090361A2 (en) 2000-05-26 2001-05-25 Modulation of inflammation by protease-treated mcp-3 chemokine

Country Status (3)

Country Link
AU (1) AU2001261971A1 (en)
CA (1) CA2316405A1 (en)
WO (1) WO2001090361A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists
EP0905241A1 (en) * 1997-09-29 1999-03-31 Applied Research Systems Ars Holding N.V. Amino-terminally truncated c-c chemokines as chemokine antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006751A1 (en) * 1996-08-16 1998-02-19 Research Corporation Technologies, Inc. Mcp-3, rantes and mip-1alpha receptor antagonists
EP0905241A1 (en) * 1997-09-29 1999-03-31 Applied Research Systems Ars Holding N.V. Amino-terminally truncated c-c chemokines as chemokine antagonists
WO1999016876A1 (en) * 1997-09-29 1999-04-08 Applied Research Systems Ars Holding N.V. Amino-terminally truncated mcp-2 as chemokine antagonists

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLARK-LEWIS I ET AL: "STRUCTURE-ACTIVITY RELATIONSHIPS OF CHEMOKINES", JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL, US, vol. 57, no. 5, 1 May 1995 (1995-05-01), pages 703 - 711, XP000569546, ISSN: 0741-5400 *
DAMME VAN J ET AL: "STRUCTURAL AND FUNCTIONAL IDENTIFICATION OF TWO HUMAN, TUMOR- DERIVED MONOCYTE CHEMOTACTIC PROTEINS (MCP-2 AND MCP-3) BELONGING TO THE CHEMOKINE FAMILY", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 176, 1 July 1992 (1992-07-01), pages 59 - 65, XP000673185, ISSN: 0022-1007 *
GONG J-H ET AL: "RANTES AND MCP-3 ANTAGONISTS BIND MULTIPLE CHEMOKINE RECEPTORS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 18, 3 May 1996 (1996-05-03), pages 10521 - 10527, XP002017746, ISSN: 0021-9258 *
MCQUIBBAN G ANGUS ET AL: "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.", SCIENCE (WASHINGTON D C), vol. 289, no. 5482, 18 August 2000 (2000-08-18), pages 1202 - 1206, XP002182216, ISSN: 0036-8075 *
OPDENAKKER G ET AL: "Human monocyte chemotactic protein-3 (MCP-3): Molecular cloning of the cDNA and comparison with other chemokinesfactor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 191, no. 2, 15 March 1993 (1993-03-15), pages 535 - 542, XP002133948, ISSN: 0006-291X *

Also Published As

Publication number Publication date
AU2001261971A1 (en) 2001-12-03
WO2001090361A2 (en) 2001-11-29
CA2316405A1 (en) 2001-11-26

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