WO2001090318A3 - Regulation de l'enzyme similaire a la polyamine oxydase humaine - Google Patents

Regulation de l'enzyme similaire a la polyamine oxydase humaine Download PDF

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Publication number
WO2001090318A3
WO2001090318A3 PCT/EP2001/005969 EP0105969W WO0190318A3 WO 2001090318 A3 WO2001090318 A3 WO 2001090318A3 EP 0105969 W EP0105969 W EP 0105969W WO 0190318 A3 WO0190318 A3 WO 0190318A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyamine oxidase
enzyme
regulation
human polyamine
reagents
Prior art date
Application number
PCT/EP2001/005969
Other languages
English (en)
Other versions
WO2001090318A2 (fr
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU72423/01A priority Critical patent/AU7242301A/en
Publication of WO2001090318A2 publication Critical patent/WO2001090318A2/fr
Publication of WO2001090318A3 publication Critical patent/WO2001090318A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/03—Oxidoreductases acting on the CH-NH group of donors (1.5) with oxygen as acceptor (1.5.3)
    • C12Y105/03013—N1-Acetylpolyamine oxidase (1.5.3.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/03—Oxidoreductases acting on the CH-NH group of donors (1.5) with oxygen as acceptor (1.5.3)
    • C12Y105/03015—N8-Acetylspermidine oxidase (propane-1,3-diamine-forming) (1.5.3.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des réactifs régulant l'activité de l'enzyme similaire à la polyamine oxydase humaine et des réactifs se liant à des produits géniques d'enzyme similaire à la polyamine oxydase humaine. On peut utiliser lesdits réactifs, en outre, pour traiter des cancers, tels que la leucémie, ainsi que des oedèmes et le volume de l'infarctus suite à une ischémie cérébrale focale transitoire et une lésion cérébrale traumatique.
PCT/EP2001/005969 2000-05-26 2001-05-25 Regulation de l'enzyme similaire a la polyamine oxydase humaine WO2001090318A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU72423/01A AU7242301A (en) 2000-05-26 2001-05-25 Regulation of human polyamine oxidase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20721700P 2000-05-26 2000-05-26
US60/207,217 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001090318A2 WO2001090318A2 (fr) 2001-11-29
WO2001090318A3 true WO2001090318A3 (fr) 2002-08-01

Family

ID=22769650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005969 WO2001090318A2 (fr) 2000-05-26 2001-05-25 Regulation de l'enzyme similaire a la polyamine oxydase humaine

Country Status (2)

Country Link
AU (1) AU7242301A (fr)
WO (1) WO2001090318A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104678002A (zh) * 2013-11-29 2015-06-03 沈阳药科大学 用于评估肺癌疾病的生物标记物
CN109321536A (zh) * 2018-11-13 2019-02-12 中国烟草总公司郑州烟草研究院 一种提高烟叶提取物中氧化酶酶活的提取方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000195A1 (fr) * 1988-06-30 1990-01-11 Xandra Breakefield Adn codant le type a d'oxydase monoaminee humaine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000195A1 (fr) * 1988-06-30 1990-01-11 Xandra Breakefield Adn codant le type a d'oxydase monoaminee humaine

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EMBL; 18 April 1997 (1997-04-18), ADAMS M D ET AL.: "EST36627 Embryo, 8 week I Homo sapiens cDNA 5' end similar to similar to monoamine oxidase B", XP002194298 *
DATABASE EM_EST EMBL; 20 February 2000 (2000-02-20), NCI-CGAP: "UI-H-BI3-aks-f-04-0-UI.s1 NCI_CGAP_Sub5 Homo sapiens cDNA clone IMAGE:2735382 3', mRNA sequence.", XP002194299 *
DATABASE SWALL EMBL; 15 December 1998 (1998-12-15), GARDNER A: "Hypothetical 60.3 kDa protein R13G10.2 in chromosome III", XP002194300 *
HOUEN G: "Mammalian Cu-containing amine oxidases (CAOs): New methods of analysis, structural relationships, and possible functions.", APMIS, vol. 107, no. Suppl. 96, 1999, pages 1 - 46, XP008001880, ISSN: 0903-4641 *
MARTON L J ET AL.: "Polyamines as targets for therapeutic intervention.", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 35, 1995, pages 55 - 91, XP008001879, ISBN: 0-8243-0435-7 *
NOVOTNY W F ET AL: "Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 13, 1994, pages 9921 - 9925, XP002194296, ISSN: 0021-9258 *
SEILER N: "Polyamine oxidase, properties and functions", PROGRESS IN BRAIN RESEARCH, vol. 106, 1995, pages 333 - 344, XP001064598 *
WANG Y ET AL.: "Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.", CANCER RESEARCH, vol. 61, no. 14, 15 July 2001 (2001-07-15), pages 5370 - 5373, XP002194297, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
AU7242301A (en) 2001-12-03
WO2001090318A2 (fr) 2001-11-29

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