WO2001087957A3 - Novel dual oxidases as mitogenic and endocrine regulators - Google Patents

Novel dual oxidases as mitogenic and endocrine regulators Download PDF

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Publication number
WO2001087957A3
WO2001087957A3 PCT/US2001/015573 US0115573W WO0187957A3 WO 2001087957 A3 WO2001087957 A3 WO 2001087957A3 US 0115573 W US0115573 W US 0115573W WO 0187957 A3 WO0187957 A3 WO 0187957A3
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WO
WIPO (PCT)
Prior art keywords
present
proteins
mitogenic
genes
activity
Prior art date
Application number
PCT/US2001/015573
Other languages
French (fr)
Other versions
WO2001087957A2 (en
WO2001087957A9 (en
Inventor
J David Lambeth
Bernard P Lassegue
Kathy K Griendling
Rebecca S Arnold
Guangijie Cheng
Lisa Sharling
Guy Benian
William A Edens
Original Assignee
J David Lambeth
Bernard P Lassegue
Kathy K Griendling
Rebecca S Arnold
Guangijie Cheng
Lisa Sharling
Guy Benian
William A Edens
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/437,568 external-priority patent/US6620603B1/en
Application filed by J David Lambeth, Bernard P Lassegue, Kathy K Griendling, Rebecca S Arnold, Guangijie Cheng, Lisa Sharling, Guy Benian, William A Edens, Univ Emory filed Critical J David Lambeth
Priority to CA002409068A priority Critical patent/CA2409068A1/en
Priority to AU6459601A priority patent/AU6459601A/en
Priority to AU2001264596A priority patent/AU2001264596B2/en
Priority to EP01939033A priority patent/EP1285071A2/en
Priority to JP2001585175A priority patent/JP2003533217A/en
Priority to US10/276,153 priority patent/US7226769B2/en
Publication of WO2001087957A2 publication Critical patent/WO2001087957A2/en
Publication of WO2001087957A3 publication Critical patent/WO2001087957A3/en
Publication of WO2001087957A9 publication Critical patent/WO2001087957A9/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Abstract

The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates and in peroxidative reactions that affect biological functions including cell division, thyroid hormone biosynthesis and tissue fibrosis. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
PCT/US2001/015573 1998-11-10 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators WO2001087957A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002409068A CA2409068A1 (en) 2000-05-15 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators
AU6459601A AU6459601A (en) 2000-05-15 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators
AU2001264596A AU2001264596B2 (en) 2000-05-15 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators
EP01939033A EP1285071A2 (en) 2000-05-15 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators
JP2001585175A JP2003533217A (en) 2000-05-15 2001-05-14 Novel double oxidases as mitogens and endocrine regulators
US10/276,153 US7226769B2 (en) 1998-11-10 2001-05-14 Dual oxidases as mitogenic and endocrine regulators

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/437,568 US6620603B1 (en) 1998-11-10 1999-11-10 Human mitogenic oxidase
US20444100P 2000-05-15 2000-05-15
US60/204,441 2000-05-15
US22242100P 2000-08-01 2000-08-01
US60/222,421 2000-08-01

Publications (3)

Publication Number Publication Date
WO2001087957A2 WO2001087957A2 (en) 2001-11-22
WO2001087957A3 true WO2001087957A3 (en) 2002-04-25
WO2001087957A9 WO2001087957A9 (en) 2002-12-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015573 WO2001087957A2 (en) 1998-11-10 2001-05-14 Novel dual oxidases as mitogenic and endocrine regulators

Country Status (5)

Country Link
EP (1) EP1285071A2 (en)
JP (1) JP2003533217A (en)
AU (2) AU2001264596B2 (en)
CA (1) CA2409068A1 (en)
WO (1) WO2001087957A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104120186A (en) * 2014-08-06 2014-10-29 广西壮族自治区妇幼保健院 Polygene sequencing primer and detecting method for detecting congenital hypothyroidism

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130199D0 (en) * 2001-12-17 2002-02-06 Syngenta Mogen Bv New nematode feeding assay
GR1004419B (en) * 2002-06-19 2004-01-15 Κιντζιοσασπυριδωναευαγγελου Method for controlling cell division and development
EP1556079A2 (en) 2002-07-16 2005-07-27 Emory University Regulatory protein for nox enzymes
WO2006133145A2 (en) * 2005-06-06 2006-12-14 Caprion Pharmaceuticals, Inc. Tat-007 and methods of assessing and treating cancer
CN107019798B (en) * 2016-02-02 2021-02-12 上海尚泰生物技术有限公司 DUOX2 modified DC vaccine and application thereof in targeted killing of pancreatic cancer initiating cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028031A2 (en) * 1998-11-10 2000-05-18 Emory University Mitogenic regulators
WO2001020001A1 (en) * 1999-09-15 2001-03-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nadph-oxidase thyroid enzyme, nucleic acid coding for same and applications thereof
WO2001049716A2 (en) * 1999-12-30 2001-07-12 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028031A2 (en) * 1998-11-10 2000-05-18 Emory University Mitogenic regulators
WO2001020001A1 (en) * 1999-09-15 2001-03-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nadph-oxidase thyroid enzyme, nucleic acid coding for same and applications thereof
WO2001049716A2 (en) * 1999-12-30 2001-07-12 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL SEQUENCE LIBARY 16 May 1997 (1997-05-16), WU X., GRAVES T.: "The sequence of C. elegans cosmid F53G12 - Caenorhabditis elegans cosmid F53G12, complete sequence", XP002190999 *
DATABASE EMBL SEQUENCE LIBRARY 23 January 1998 (1998-01-23), TIN-WOLLAM A., WOHLDMANN P., MORRIS M.: "The sequence of C. elegans cosmid F56C11 - Caenorhabditis elegans cosmid F56C11, complete sequence", XP002191000 *
DATABASE EMBL SEQUENCE LIBRARY 24 May 2000 (2000-05-24), SHARLING L., CHENG G., EDENS W.A., SHAPIRA R., KINKADE J., LEE T., BENIAN G., LAMBETH D.: "Extracellular Matrix Biogenesis by Duox, a Multidomain Oxidase/Peroxidase with Homology to the Phagocyte Oxidase Subunit gp91phox - Caenorhabditis elegans dual oxidase mRNA, complete cds", XP002191003 *
DATABASE EMBL SEQUENCE LIBRARY 4 July 2000 (2000-07-04), CHENG G., LEE T., LAMBETH D.: "A bifunctional oxidase (DUOX2) with 77% identity to human DUOX1 and containing regions similar to the superoxide-generating gp91phox and to peroxidases - unpublished", XP002191002 *
DATABASE EMBL SEQUENCE LIBRARY 7 June 2000 (2000-06-07), DE DEKEN, X., ET AL.: "Homo sapiens NADPH thyroid oxidase2 (thOX2) mRNA, complete cds.", XP002191005 *
DATABASE TREMBL DATABASE 1 August 1998 (1998-08-01), TIN-WOLLAM, A., ET AL.: "The sequence of C. elegans cosmid F65C11", XP002191001 *
DATABASE TREMBL DATABASE 1 October 2000 (2000-10-01), SHARLING, L., ET AL.: "Extracellular Matrix Biogenesis by Duox, a Multidomain Oxidase/Peroxidase with Homology to the Phagocyte Oxidase Subunit gp91phox", XP002191004 *
DE DEKEN XAVIER ET AL: "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 30, 28 July 2000 (2000-07-28), pages 23227 - 23233, XP002190997, ISSN: 0021-9258 *
DUPUY ET AL: "Homo sapiens NADH/NADPH thyroid oxidase p138-tox mRNA, complete cds.", EMBL SEQUENCE LIBRARY, XP002144980 *
DUPUY ET AL: "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 52, 24 December 1999 (1999-12-24), pages 37265 - 37269, XP002144979, ISSN: 0021-9258 *
EDENS WILLIAM A ET AL: "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.", JOURNAL OF CELL BIOLOGY, vol. 154, no. 4, 20 August 2001 (2001-08-20), pages 879 - 891, XP002190998, ISSN: 0021-9525 *
LAMBETH J D ET AL: "Novel homologs of gp91phox", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 25, no. 10, 1 October 2000 (2000-10-01), pages 459 - 461, XP004224276, ISSN: 0968-0004 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104120186A (en) * 2014-08-06 2014-10-29 广西壮族自治区妇幼保健院 Polygene sequencing primer and detecting method for detecting congenital hypothyroidism
CN104120186B (en) * 2014-08-06 2017-07-11 广西壮族自治区妇幼保健院 Congenital hypothyroidism polygenes sequencing primer and detection method

Also Published As

Publication number Publication date
WO2001087957A2 (en) 2001-11-22
JP2003533217A (en) 2003-11-11
CA2409068A1 (en) 2001-11-22
EP1285071A2 (en) 2003-02-26
AU2001264596B2 (en) 2006-06-15
WO2001087957A9 (en) 2002-12-12
AU6459601A (en) 2001-11-26

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