WO2001085917A3 - A device - Google Patents

A device Download PDF

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Publication number
WO2001085917A3
WO2001085917A3 PCT/GB2001/002056 GB0102056W WO0185917A3 WO 2001085917 A3 WO2001085917 A3 WO 2001085917A3 GB 0102056 W GB0102056 W GB 0102056W WO 0185917 A3 WO0185917 A3 WO 0185917A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
committed
undifferentiated
retrodifferentiate
contacting
Prior art date
Application number
PCT/GB2001/002056
Other languages
French (fr)
Other versions
WO2001085917A2 (en
Inventor
Ilham Mohamed Sale Abuljadayel
Original Assignee
Tristem Trading Cyprus Ltd
Ilham Mohamed Sale Abuljadayel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447916&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001085917(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/568,254 external-priority patent/US9068164B1/en
Priority claimed from GB0101315A external-priority patent/GB0101315D0/en
Priority claimed from GB0107093A external-priority patent/GB0107093D0/en
Priority to BR122012019753A priority Critical patent/BR122012019753B1/en
Priority to KR1020027015131A priority patent/KR100875089B1/en
Priority to EP01929796A priority patent/EP1366144B1/en
Priority to MXPA02012295A priority patent/MXPA02012295A/en
Priority to CA2446955A priority patent/CA2446955C/en
Priority to BRPI0110751-8A priority patent/BRPI0110751B1/en
Application filed by Tristem Trading Cyprus Ltd, Ilham Mohamed Sale Abuljadayel filed Critical Tristem Trading Cyprus Ltd
Priority to AU56477/01A priority patent/AU5647701A/en
Priority to BR0110751-8A priority patent/BR0110751A/en
Priority to IL15273701A priority patent/IL152737A0/en
Priority to DE60139716T priority patent/DE60139716D1/en
Priority to DK01929796T priority patent/DK1366144T3/en
Priority to AT01929796T priority patent/ATE440944T1/en
Priority to JP2001582506A priority patent/JP4860883B2/en
Publication of WO2001085917A2 publication Critical patent/WO2001085917A2/en
Priority to IL152737A priority patent/IL152737A/en
Publication of WO2001085917A3 publication Critical patent/WO2001085917A3/en
Priority to HK06112473.5A priority patent/HK1091860A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/14—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Computer Hardware Design (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Thermal Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A device for preparing an undifferentiated cell, the device comprises means for contacting a more committed cell with an agent that causes the more committed cell to retrodifferentiate into an undifferentiated cell.
PCT/GB2001/002056 2000-05-10 2001-05-10 A device WO2001085917A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DE60139716T DE60139716D1 (en) 2000-05-10 2001-05-10 DEVICE FOR PREPARING CELLS
DK01929796T DK1366144T3 (en) 2000-05-10 2001-05-10 Device for producing cells
AT01929796T ATE440944T1 (en) 2000-05-10 2001-05-10 DEVICE FOR PREPARING CELLS
JP2001582506A JP4860883B2 (en) 2000-05-10 2001-05-10 apparatus
IL15273701A IL152737A0 (en) 2000-05-10 2001-05-10 A device for preparing an undifferentiated cell
EP01929796A EP1366144B1 (en) 2000-05-10 2001-05-10 A device for preparing cells
MXPA02012295A MXPA02012295A (en) 2000-05-10 2001-05-10 A device.
CA2446955A CA2446955C (en) 2000-05-10 2001-05-10 A device for forming or increasing the number of undifferentiated cells
BRPI0110751-8A BRPI0110751B1 (en) 2000-05-10 2001-05-10 DEVICE
BR122012019753A BR122012019753B1 (en) 2000-05-10 2001-05-10 retrodifferentiation process of compromised cells
AU56477/01A AU5647701A (en) 2000-05-10 2001-05-10 A device
BR0110751-8A BR0110751A (en) 2000-05-10 2001-05-10 Device
KR1020027015131A KR100875089B1 (en) 2000-05-10 2001-05-10 Apparatus for increasing the relative number of undifferentiated cells in a cell population including committed cells
IL152737A IL152737A (en) 2000-05-10 2002-11-10 Device for preparing an undifferentiated cell
HK06112473.5A HK1091860A1 (en) 2000-05-10 2006-11-13 A device

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US09/568,254 US9068164B1 (en) 1995-02-02 2000-05-10 Method of preparing an undifferentiated cell
US09/568,254 2000-05-10
GB0101315.0 2001-01-18
GB0101315A GB0101315D0 (en) 2001-01-18 2001-01-18 A device
US27149701P 2001-02-26 2001-02-26
US60/271,497 2001-02-26
GB0107093.7 2001-03-21
GB0107093A GB0107093D0 (en) 2001-03-21 2001-03-21 A device

Publications (2)

Publication Number Publication Date
WO2001085917A2 WO2001085917A2 (en) 2001-11-15
WO2001085917A3 true WO2001085917A3 (en) 2003-10-09

Family

ID=27447916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002056 WO2001085917A2 (en) 2000-05-10 2001-05-10 A device

Country Status (27)

Country Link
US (1) US8163536B2 (en)
EP (1) EP1366144B1 (en)
JP (2) JP4860883B2 (en)
KR (2) KR100875089B1 (en)
AR (1) AR030280A1 (en)
AT (1) ATE440944T1 (en)
AU (1) AU5647701A (en)
BE (1) BE1014172A3 (en)
BR (2) BRPI0110751B1 (en)
CA (2) CA2776904A1 (en)
CH (1) CH696146B9 (en)
CY (1) CY1109515T1 (en)
DE (1) DE60139716D1 (en)
DK (1) DK1366144T3 (en)
ES (2) ES2190727B1 (en)
FR (1) FR2808800B1 (en)
GB (2) GB2366295B (en)
HK (2) HK1044172A1 (en)
IL (2) IL152737A0 (en)
IT (1) ITMI20010952A1 (en)
JO (1) JO2295B1 (en)
MA (1) MA25677A1 (en)
MX (1) MXPA02012295A (en)
NL (1) NL1017973C2 (en)
NZ (2) NZ540481A (en)
SA (1) SA01220163B1 (en)
WO (1) WO2001085917A2 (en)

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TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
WO2005005620A1 (en) * 2003-07-11 2005-01-20 Blasticon Biotechnologische Forschung Gmbh Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
DE10231655A1 (en) * 2002-07-12 2004-02-26 Blasticon Biotechnologische Forschung Gmbh Graft acceptance-inducing cells of monocytic origin, as well as their production and use
CA2479164A1 (en) * 2002-07-25 2004-02-05 Japan Science And Technology Agency Alternate immersion apparatus and alternate immersion method for treating biological sample
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KR101505202B1 (en) 2006-03-07 2015-03-27 지타 쉬로프 Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
EP3441459B1 (en) 2006-08-02 2021-03-17 Technion Research & Development Foundation Limited Methods of expanding embryonic stem cells in a suspension culture
CN102851254A (en) * 2007-03-01 2013-01-02 干细胞国际公司 Procurement, isolation, and cryopreservation of endometrial/menstrual cells
GB0917565D0 (en) * 2009-10-08 2009-11-25 Univ Nottingham An observation cell arrangement
GB2474492B (en) * 2009-10-19 2014-05-21 Tristem Trading Cyprus Ltd Treatment using reprogrammed mature adult cells
ES2932664T3 (en) 2009-11-12 2023-01-23 Technion Res & Dev Foundation Culture media, cell cultures and methods of culturing pluripotent stem cells in the undifferentiated state
EP2639294A1 (en) * 2012-03-15 2013-09-18 CellProthera Automaton and automated method for cell culture
KR20160075676A (en) 2013-10-24 2016-06-29 오스페달레 산 라파엘 에스.알.엘. Method
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
IL305882A (en) 2016-05-25 2023-11-01 Inst Nat Sante Rech Med Methods and compositions for treating cancers
US10711237B2 (en) * 2017-08-22 2020-07-14 Idex Health & Science Llc Apparatus and methods for bioprocesses and other processes
AU2018371212A1 (en) 2017-11-24 2020-06-11 Assistance Publique - Hôpitaux De Paris Methods and compositions for treating cancers
CN108889357A (en) * 2018-05-10 2018-11-27 刘英文 A kind of clinical laboratory's sample temporary storing device
WO2020030634A1 (en) 2018-08-06 2020-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
CN111560345A (en) * 2019-05-10 2020-08-21 华中科技大学同济医学院附属协和医院 Method for separating and purifying primary valvular endothelial cells of pigs
US20240279612A1 (en) 2021-04-01 2024-08-22 Institut National de la Santé et de la Recherche Médicale Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof

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GB2297558A (en) * 1995-02-02 1996-08-07 Ilham Mohamed Sale Abuljadayel Conversion of a more committed cell into an undifferentiated cell
FR2771421A1 (en) * 1997-11-27 1999-05-28 Bertin & Cie Blood cell culture chamber with homogeneous gas and media distribution
FR2794130A1 (en) * 1999-05-26 2000-12-01 Bertin Technologies Sa METHOD AND DEVICE FOR CULTURING MULTI-APPLICATION CELLS

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