WO2001085764A3 - Regulation of human p2y-like g protein-coupled receptor - Google Patents

Regulation of human p2y-like g protein-coupled receptor Download PDF

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Publication number
WO2001085764A3
WO2001085764A3 PCT/EP2001/005244 EP0105244W WO0185764A3 WO 2001085764 A3 WO2001085764 A3 WO 2001085764A3 EP 0105244 W EP0105244 W EP 0105244W WO 0185764 A3 WO0185764 A3 WO 0185764A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
asthma
disease
coupled receptor
human
Prior art date
Application number
PCT/EP2001/005244
Other languages
French (fr)
Other versions
WO2001085764A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001272400A priority Critical patent/AU2001272400A1/en
Priority to EP01951488A priority patent/EP1282707A2/en
Publication of WO2001085764A2 publication Critical patent/WO2001085764A2/en
Publication of WO2001085764A3 publication Critical patent/WO2001085764A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents which regulate human P2Y-like G protein-coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, diabetes, angina pectoris, myocardial infarction, ulcers, asthma, COPD, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
PCT/EP2001/005244 2000-05-11 2001-05-09 Regulation of human p2y-like g protein-coupled receptor WO2001085764A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001272400A AU2001272400A1 (en) 2000-05-11 2001-05-09 Regulation of human p2y-like g protein-coupled receptor
EP01951488A EP1282707A2 (en) 2000-05-11 2001-05-09 Regulation of human p2y-like g protein-coupled receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20358200P 2000-05-11 2000-05-11
US60/203,582 2000-05-11
US26985701P 2001-02-21 2001-02-21
US60/269,857 2001-02-21

Publications (2)

Publication Number Publication Date
WO2001085764A2 WO2001085764A2 (en) 2001-11-15
WO2001085764A3 true WO2001085764A3 (en) 2002-11-28

Family

ID=26898728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005244 WO2001085764A2 (en) 2000-05-11 2001-05-09 Regulation of human p2y-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1282707A2 (en)
AU (1) AU2001272400A1 (en)
WO (1) WO2001085764A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001280785A1 (en) * 2000-07-27 2002-02-13 Incyte Genomics, Inc. G-protein coupled receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009998A1 (en) * 1997-08-29 1999-03-04 The University Of North Carolina At Chapel Hill Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
WO2001048188A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009998A1 (en) * 1997-08-29 1999-03-04 The University Of North Carolina At Chapel Hill Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
WO2001048188A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BOEYNAEMS J-M J-M ET AL: "P2Y receptors: in the middle of the road", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 1, January 2000 (2000-01-01), pages 1 - 3, XP004189127, ISSN: 0165-6147 *
COMMUNI D ET AL: "RECEPTORS RESPONSIVE TO EXTRACELLULAR URACIL NUCLEOTIDES", DRUG DEVELOPMENT RESEARCH, NEW YORK, NY, US, vol. 3/4, no. 45, November 1998 (1998-11-01), pages 130 - 134, XP001073456, ISSN: 0272-4391 *
DATABASE EMBL [online] 18 July 1997 (1997-07-18), "Homo sapiens P2Y6 receptor, long splice variant mRNA, complete cds.", XP002210111, Database accession no. AF007892 *
DATABASE EMBL [online] 23 June 1998 (1998-06-23), "Meleagris gallopavo G protein-coupled receptor p2y3 (p2y3) gene, complete cds.", XP002210110, Database accession no. AF069555 *
DATABASE EMBL [online] 27 March 2000 (2000-03-27), "Homo sapiens chromosome 3 clone RP11-170K4 map 3, WORKING DRAFT SEQUENCE,15 unordered pieces.", XP002210109, Database accession no. AC026960 *
DATABASE SWISSPROT [online] 1 November 1997 (1997-11-01), XP002210112, Database accession no. Q15077 *
LI QING ET AL: "Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor.", MOLECULAR PHARMACOLOGY, vol. 54, no. 3, 1998, pages 541 - 546, XP002210108, ISSN: 0026-895X *
WEBB T E ET AL: "A NOVEL G PROTEIN-COUPLED P2 PURINOCEPTOR (P2Y3) ACTIVATED PREFERENTIALLY BY NUCLEOSIDE DIPHOSPHATES", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 50, no. 2, 1 August 1996 (1996-08-01), pages 258 - 265, XP000673090, ISSN: 0026-895X *

Also Published As

Publication number Publication date
WO2001085764A2 (en) 2001-11-15
AU2001272400A1 (en) 2001-11-20
EP1282707A2 (en) 2003-02-12

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