WO2001083749A3 - Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners - Google Patents

Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners Download PDF

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Publication number
WO2001083749A3
WO2001083749A3 PCT/US2001/013387 US0113387W WO0183749A3 WO 2001083749 A3 WO2001083749 A3 WO 2001083749A3 US 0113387 W US0113387 W US 0113387W WO 0183749 A3 WO0183749 A3 WO 0183749A3
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WO
WIPO (PCT)
Prior art keywords
present
relates
gene
sequence variation
ethanol
Prior art date
Application number
PCT/US2001/013387
Other languages
French (fr)
Other versions
WO2001083749A2 (en
Inventor
Alexander A Bachmanov
Gary K Beauchamp
Aurobindo Chatterjee
Jong Pieter J De
Shanru Li
Xia Li
Jeffrey D Ohmen
Danielle R Reed
David Ross
Michael Guy Tordoff
Original Assignee
Warner Lambert Co
Monell Chemical Senses Centre
Alexander A Bachmanov
Gary K Beauchamp
Aurobindo Chatterjee
Jong Pieter J De
Shanru Li
Xia Li
Jeffrey D Ohmen
Danielle R Reed
David Ross
Michael Guy Tordoff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Monell Chemical Senses Centre, Alexander A Bachmanov, Gary K Beauchamp, Aurobindo Chatterjee, Jong Pieter J De, Shanru Li, Xia Li, Jeffrey D Ohmen, Danielle R Reed, David Ross, Michael Guy Tordoff filed Critical Warner Lambert Co
Priority to AU2001255681A priority Critical patent/AU2001255681A1/en
Priority to EP01928871A priority patent/EP1280899A2/en
Priority to CA002406999A priority patent/CA2406999A1/en
Priority to JP2001580356A priority patent/JP2003531614A/en
Publication of WO2001083749A2 publication Critical patent/WO2001083749A2/en
Publication of WO2001083749A3 publication Critical patent/WO2001083749A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to the discovery of a gene and its sequence variation associated with preference for carbohydrates, other sweet compounds, or ethanol. The present invention also relates to the study of metabolic pathways to identify other genes, receptors, and relationships that contribute to differences in sensing of carbohydrates or ethanol. The present invention also relates to germline or somatic sequence variations and its use in the diagnosis and prognosis of predisposition to diabetes, other obesity related disorders, or ethanol consumption. The present invention also provided probes or primers specific for the detection and analysis of such sequence variation. The present invention also relates to method for screening drugs for inhibition or restoration of gene function as antidiabetic, antiobesity, or antialcohol consumption therapies. The present invention relates to other antidiabetic, antiobesity disorder, or antialcohol consumption therapies, such as gene therapy, protein replacement therapy, etc. Finally, the present invention relates to a method for identifying sweeteners or alcohols utilizing the gene and its variations.
PCT/US2001/013387 2000-04-28 2001-04-25 Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners WO2001083749A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001255681A AU2001255681A1 (en) 2000-04-28 2001-04-25 Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners
EP01928871A EP1280899A2 (en) 2000-04-28 2001-04-25 Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners
CA002406999A CA2406999A1 (en) 2000-04-28 2001-04-25 Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners
JP2001580356A JP2003531614A (en) 2000-04-28 2001-04-25 Gene and sequence variations associated with the sensing of carbohydrate compounds and other sweet substances

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US20079400P 2000-04-28 2000-04-28
US60/200,794 2000-04-28
US22141900P 2000-07-28 2000-07-28
US60/221,419 2000-07-28
US24744300P 2000-11-10 2000-11-10
US60/247,443 2000-11-10

Publications (2)

Publication Number Publication Date
WO2001083749A2 WO2001083749A2 (en) 2001-11-08
WO2001083749A3 true WO2001083749A3 (en) 2002-07-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013387 WO2001083749A2 (en) 2000-04-28 2001-04-25 Gene and sequence variation associated with sensing carbohydrate compounds and other sweeteners

Country Status (5)

Country Link
EP (1) EP1280899A2 (en)
JP (1) JP2003531614A (en)
AU (1) AU2001255681A1 (en)
CA (1) CA2406999A1 (en)
WO (1) WO2001083749A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
WO2001090359A2 (en) * 2000-05-22 2001-11-29 Incyte Genomics, Inc. G-protein coupled receptors
AU2001295578A1 (en) * 2000-09-25 2002-04-02 Bayer Aktiengesellschaft Regulation of human g protein-coupled receptor
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064882A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
WO2001066563A2 (en) * 2000-03-07 2001-09-13 Senomyx, Inc. T1r taste receptors and genes encoding same
WO2001090359A2 (en) * 2000-05-22 2001-11-29 Incyte Genomics, Inc. G-protein coupled receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064882A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
WO2001066563A2 (en) * 2000-03-07 2001-09-13 Senomyx, Inc. T1r taste receptors and genes encoding same
WO2001090359A2 (en) * 2000-05-22 2001-11-29 Incyte Genomics, Inc. G-protein coupled receptors

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BACHMANOV A A ET AL: "Positional cloning of the mouse saccharin preference (Sac) locus.", CHEMICAL SENSES., vol. 26, no. 7, September 2001 (2001-09-01), pages 925 - 933, XP001073408, ISSN: 0379-864X *
BACHMANOV ALEXANDER A ET AL: "Sucrose consumption in mice: Major influence of two genetic loci affecting peripheral sensory responses.", MAMMALIAN GENOME, vol. 8, no. 8, 1997, pages 545 - 548, XP002197056, ISSN: 0938-8990 *
HOON M A ET AL: "PUTATIVE MAMMALIAN TASTE RECEPTORS: A CLASS OF TASTE-SPECIFIC GPCRS WITH DISTINCT TOPOGRAPHIC SELECTIVITY", CELL, vol. 96, 19 February 1999 (1999-02-19), pages 541 - 551, XP000922524, ISSN: 0092-8674 *
KITAGAWA M ET AL: "Molecular genetic identification of a candidate receptor gene for sweet taste.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 283, no. 1, 27 April 2001 (2001-04-27), pages 236 - 242, XP002197055, ISSN: 0006-291X *
MAX MARIANNA ET AL: "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.", NATURE GENETICS, vol. 28, no. 1, May 2001 (2001-05-01), pages 58 - 63, XP002197059, ISSN: 1061-4036 *
MONTMAYEUR J P ET AL: "A candidate taste receptor gene near a sweet taste locus.", NATURE NEUROSCIENCE, vol. 4, no. 5, May 2001 (2001-05-01), pages 492 - 498, XP001073542, ISSN: 1097-6256 *
NELSON G ET AL: "Mammalian sweet taste receptors.", CELL, vol. 106, no. 3, 10 August 2001 (2001-08-10), pages 381 - 390, XP002197058, ISSN: 0092-8674 *
SAINZ E ET AL: "Identification of a novel member of the T1R family of putative taste receptors.", JOURNAL OF NEUROCHEMISTRY, vol. 77, no. 3, May 2001 (2001-05-01), pages 896 - 903, XP002197057, ISSN: 0022-3042 *
Scientific Meeting of the Research Society on Alcoholism;Hilton Head Island, South Carolina, USA; June 20-25, 1998 *
TORDOFF M G ET AL: "Influence of saccharin preference (sac) locus on ethanol preference in mice.", ALCOHOLISM CLINICAL AND EXPERIMENTAL RESEARCH, vol. 22, no. 3 ABSTR. SUPPL., May 1998 (1998-05-01), Abstract 587, pages 101A, XP001073549, ISSN: 0145-6008 *

Also Published As

Publication number Publication date
WO2001083749A2 (en) 2001-11-08
JP2003531614A (en) 2003-10-28
AU2001255681A1 (en) 2001-11-12
EP1280899A2 (en) 2003-02-05
CA2406999A1 (en) 2001-11-08

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