WO2001083715A8 - Derivation of midbrain dopaminergic neurons from embryonic stem cells - Google Patents
Derivation of midbrain dopaminergic neurons from embryonic stem cellsInfo
- Publication number
- WO2001083715A8 WO2001083715A8 PCT/US2001/014051 US0114051W WO0183715A8 WO 2001083715 A8 WO2001083715 A8 WO 2001083715A8 US 0114051 W US0114051 W US 0114051W WO 0183715 A8 WO0183715 A8 WO 0183715A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- cns
- differentiated
- expansion
- cns precursor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/258,975 US20030211605A1 (en) | 2001-05-01 | 2001-05-01 | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
AU2001259323A AU2001259323A1 (en) | 2000-05-01 | 2001-05-01 | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20100500P | 2000-05-01 | 2000-05-01 | |
US60/201,005 | 2000-05-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2001083715A2 WO2001083715A2 (en) | 2001-11-08 |
WO2001083715A3 WO2001083715A3 (en) | 2002-05-23 |
WO2001083715A8 true WO2001083715A8 (en) | 2002-12-27 |
Family
ID=22744085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/014051 WO2001083715A2 (en) | 2000-05-01 | 2001-05-01 | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001259323A1 (en) |
WO (1) | WO2001083715A2 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
DE60129943T2 (en) * | 2000-02-11 | 2008-05-08 | Philadelphia Health And Education Corp. | DIFFERENTIATION OF BONE MARROW CELLS IN NEURONAL CELLS AND THEIR USES |
US20020009743A1 (en) | 2000-05-17 | 2002-01-24 | Carpenter Melissa K. | Neural progenitor cell populations |
US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
US7588937B2 (en) | 2001-10-03 | 2009-09-15 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
US6887706B2 (en) | 2001-10-03 | 2005-05-03 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells |
US8153424B2 (en) | 2001-10-03 | 2012-04-10 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
AU2002367091A1 (en) * | 2001-12-28 | 2003-07-15 | Cellartis Ab | A method for the establishment of a pluripotent human blastocyst-derived stem cell line |
CA2473115A1 (en) * | 2002-01-09 | 2003-07-24 | Japan Science And Technology Agency | Remedy for dysmnesia |
US20030162290A1 (en) * | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
WO2003104444A1 (en) * | 2002-06-05 | 2003-12-18 | Es Cell International Pte Ltd | Generation of neural stem cells from undifferentiated human embryonic stem cells |
EP1534068A4 (en) * | 2002-08-08 | 2006-08-23 | Univ Georgia Res Found | Compositions and methods for neural differentiation of embryonic stem cells |
CA2518577A1 (en) | 2003-03-12 | 2004-09-23 | Reliance Life Sciences Pvt. Ltd. | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
CA2524611A1 (en) | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for efficient transfer of human blastocyst-derived stem cells (hbs cells) from a feeder-supported to a feeder-free culture system |
WO2004099395A2 (en) * | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for the generation of neural progenitor cells |
WO2005017131A2 (en) * | 2003-08-14 | 2005-02-24 | THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES | Methods for the differentiation of human stem cells |
KR20080109943A (en) * | 2003-08-29 | 2008-12-17 | 위스콘신 얼럼나이 리서어치 화운데이션 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
US7820439B2 (en) | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
US20080199437A1 (en) | 2004-07-22 | 2008-08-21 | Eisai Co., Ltd. | Lrp4/Corin Dopaminergic Neuron Progenitor Cell Markers |
DE102004062376A1 (en) | 2004-12-14 | 2006-06-22 | Newfrey Llc, Newark | Method and power supply for generating an electric arc current and system for short-time arc stud welding |
GB0623635D0 (en) * | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
DK2710124T3 (en) * | 2011-05-20 | 2016-05-09 | Mclean Hospital Corp | NEURONAL PROGENITOR CELLS AND APPLICATIONS THEREOF |
US9453840B2 (en) | 2011-07-27 | 2016-09-27 | Kyoto University | Markers for dopaminergic neuron progenitor cells |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009936A1 (en) * | 1989-12-26 | 1991-07-11 | Hana Biologics, Inc. | Proliferated neuron progenitor cell product and process |
DE19756864C5 (en) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neural precursor cells, methods for their production and their use for the therapy of neural defects |
JP3291698B2 (en) * | 1998-07-24 | 2002-06-10 | スティーブン・カーティン | Variable eyeglass lens |
-
2001
- 2001-05-01 WO PCT/US2001/014051 patent/WO2001083715A2/en active Application Filing
- 2001-05-01 AU AU2001259323A patent/AU2001259323A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2001259323A1 (en) | 2001-11-12 |
WO2001083715A2 (en) | 2001-11-08 |
WO2001083715A3 (en) | 2002-05-23 |
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