WO2001079162A3 - INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES - Google Patents

INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES Download PDF

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Publication number
WO2001079162A3
WO2001079162A3 PCT/US2001/012563 US0112563W WO0179162A3 WO 2001079162 A3 WO2001079162 A3 WO 2001079162A3 US 0112563 W US0112563 W US 0112563W WO 0179162 A3 WO0179162 A3 WO 0179162A3
Authority
WO
WIPO (PCT)
Prior art keywords
ced
ice
family
inhibitors
cysteine proteases
Prior art date
Application number
PCT/US2001/012563
Other languages
French (fr)
Other versions
WO2001079162A2 (en
Inventor
Robert J Ternansky
Patricia L Gladstone
Kevin J Tomaselli
Original Assignee
Idun Pharmaceuticals Inc
Robert J Ternansky
Patricia L Gladstone
Kevin J Tomaselli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idun Pharmaceuticals Inc, Robert J Ternansky, Patricia L Gladstone, Kevin J Tomaselli filed Critical Idun Pharmaceuticals Inc
Priority to CA002406247A priority Critical patent/CA2406247A1/en
Priority to AU2001253633A priority patent/AU2001253633A1/en
Priority to EP01927155A priority patent/EP1276717A2/en
Publication of WO2001079162A2 publication Critical patent/WO2001079162A2/en
Publication of WO2001079162A3 publication Critical patent/WO2001079162A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention is directed to novel sulfonamide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the structure shown in Figure 1, wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
PCT/US2001/012563 2000-04-17 2001-04-17 INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES WO2001079162A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002406247A CA2406247A1 (en) 2000-04-17 2001-04-17 Inhibitors of the ice/ced-3 family of cysteine proteases
AU2001253633A AU2001253633A1 (en) 2000-04-17 2001-04-17 Inhibitors of the ice/ced-3 family of cysteine proteases
EP01927155A EP1276717A2 (en) 2000-04-17 2001-04-17 Inhibitors of the ice/ced-3 family of cysteine proteases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55091700A 2000-04-17 2000-04-17
US09/550,917 2000-04-17

Publications (2)

Publication Number Publication Date
WO2001079162A2 WO2001079162A2 (en) 2001-10-25
WO2001079162A3 true WO2001079162A3 (en) 2002-02-28

Family

ID=24199099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012563 WO2001079162A2 (en) 2000-04-17 2001-04-17 INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES

Country Status (4)

Country Link
EP (1) EP1276717A2 (en)
AU (1) AU2001253633A1 (en)
CA (1) CA2406247A1 (en)
WO (1) WO2001079162A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7317019B2 (en) 2003-08-21 2008-01-08 Bristol Myers Squibb Co. N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity
CA2634743C (en) 2005-12-23 2014-07-29 Zealand Pharma A/S Modified lysine-mimetic compounds
EP2468724B1 (en) 2006-12-21 2015-11-18 Zealand Pharma A/S Synthesis of pyrrolidine compounds
DK3618847T3 (en) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP junction modulators of intercellular communication and their use in the treatment of diabetic eye disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11147873A (en) * 1997-11-13 1999-06-02 Yamanouchi Pharmaceut Co Ltd New sulfonamide derivative and medicine
WO2000001666A1 (en) * 1998-07-02 2000-01-13 Idun Pharmaceuticals, Inc. C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11147873A (en) * 1997-11-13 1999-06-02 Yamanouchi Pharmaceut Co Ltd New sulfonamide derivative and medicine
WO2000001666A1 (en) * 1998-07-02 2000-01-13 Idun Pharmaceuticals, Inc. C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 11 30 September 1999 (1999-09-30) *
Y. OKAMOTO, ET AL.: "Peptide-based interleukin-1beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 47, no. 1, January 1999 (1999-01-01), Pharmaceutical Society of Japan, Tokyo, JP, pages 11 - 21, XP002180503, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
WO2001079162A2 (en) 2001-10-25
EP1276717A2 (en) 2003-01-22
CA2406247A1 (en) 2001-10-25
AU2001253633A1 (en) 2001-10-30

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