WO2001077689A1 - Dispositif pour la mise en oeuvre de procedes chimiques ou biologiques - Google Patents

Dispositif pour la mise en oeuvre de procedes chimiques ou biologiques Download PDF

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Publication number
WO2001077689A1
WO2001077689A1 PCT/EP2001/003975 EP0103975W WO0177689A1 WO 2001077689 A1 WO2001077689 A1 WO 2001077689A1 EP 0103975 W EP0103975 W EP 0103975W WO 0177689 A1 WO0177689 A1 WO 0177689A1
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WO
WIPO (PCT)
Prior art keywords
belt conveyor
sample vessels
conveyor
belt
base plate
Prior art date
Application number
PCT/EP2001/003975
Other languages
German (de)
English (en)
Inventor
Rainer Gauchel
Wolfgang Heimberg
Original Assignee
Mwg-Biotech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mwg-Biotech Ag filed Critical Mwg-Biotech Ag
Priority to AU2001256264A priority Critical patent/AU2001256264A1/en
Publication of WO2001077689A1 publication Critical patent/WO2001077689A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Definitions

  • the present invention relates to a device for automatically carrying out chemical or biological methods in sample vessels, in particular for sequencing and amplifying nucleic acid sequences according to the preamble of claim 1.
  • No. 5,443,791 already discloses a device for carrying out chemical or biological processes, which has several work stations. These workstations are a thermal cycler, an active cooled enzyme storage station, a washing station, a reagent storage station and a DNA sample station. Temperature profiles can be traversed with the thermal cycler, so that corresponding temperature profiles are established in the samples in the thermal cycler, so that the thermal cycler is, for example, a device for carrying out a biological process, such as for example the PC R process.
  • a device of the generic type can also have a device for preparing such a method, such as, for example, a separating device which fills a microtiter plate with samples to be examined. Such a microtiter plate is then moved with an automatic handling device arranged on the device within the travel range of the handling device.
  • a generic device has become known, for example, from WO 99/26070 to the applicant.
  • several thermal cyclers can be provided on this device.
  • the sample containers to be examined are then inserted into the thermal cycler in the form of the microtiter plates.
  • the microtiter plates kept in stock are then fed to the device by an operator, so that the handling device provided on the device can then pick up these microtiter plates and then convey them further to the individual work stations in the travel area of the device. It is a monotonous step for the operator, which is also complex and tiring.
  • a robot unit has been set up, which feeds the individual sample vessels to the automatic device so that they are then taken over by the automatic handling device.
  • Such a robot unit is a multifunctional machine which is provided with its own control and can be moved on a platform and is equipped with degrees of freedom for movement in all spatial directions, which can possibly fulfill the aforementioned task of feeding the sample vessels to the automatic device but only if an extremely high capital expenditure is accepted due to this mechanically and electronically extremely complex robot unit.
  • WO 98/52047 A1 has disclosed a sample analysis device with a plurality of handling devices, this known sample analysis device having a belt conveyor instead of the robot, which moves along a sample distribution platform and transports plates.
  • the belt conveyor transports the samples from a large storage area to and away from the sample analysis device.
  • the present invention is based on the object of developing the device of the type mentioned at the outset in such a way that its throughput relating to the handling of empty or already filled different sample vessels can be increased without the need for a complex and cost-intensive robot unit.
  • a device for automatic provide chemical or biological methods in sample vessels, in particular for sequencing and amplifying nucleic acid sequences, with at least one device for preparing and / or carrying out the methods and at least one handling device for handling the sample vessels, the device being a belt conveyor for feeding and / or Transporting the sample vessels to and / or away from the handling device and the conveying area of the belt conveyor extending beyond the outer dimensions of a base plate of the device.
  • a conveyor carriage for receiving sample vessels with different dimensions and different contact surfaces facing the conveyor carriage is provided on the belt conveyor.
  • a belt conveyor is provided, with which empty or already filled sample containers can be conveyed into the working area of the handling device and also out of this working area.
  • the belt conveyor it is possible to use the belt conveyor to transport empty sample vessels from a storage area outside the automatic device into the work area of the handling device arranged there, so that the handling device then takes over the empty sample vessels and, for example, a pipetting device provided there for filling with samples to be examined and thus feeds in preparation for a biological or chemical process.
  • the belt conveyor can feed sample containers already filled with samples from, for example, a storage stack outside the automatic device into the handling area of the handling device, so that these sample containers then filled from the handling device to a device for carrying out a chemical or biological process, for example be fed to a thermal cycler.
  • Empty sample vessels can also be transported from outside the working area of the automatic handling device, which then takes it over, feeds it to a pipetting device, there the samples and reagents to be examined and the like.
  • the handling device then feeds these filled sample containers in the form of, for example, microtiter plates to the belt conveyor, and the conveyor device then feeds the prepared sample containers to a storage stack outside the automatic device for intermediate storage and then removes them from the intermediate storage device, and the handling device feeds again when a device provided on the automatic device for carrying out a chemical or biological process, for example a thermal cycler, is ready for receiving the filled sample vessel.
  • a device provided on the automatic device for carrying out a chemical or biological process for example a thermal cycler
  • the belt conveyor is a significant simplification in mechanical and electronic terms and therefore in terms of the costs involved, since the belt conveyor allows the sample vessels to move in the direction of the conveying direction, but is not designed to move the sample vessels in all spatial directions , which is the case with the known robot unit, but is not required for handling the sample vessels. Due to the design of the belt conveyor with a conveyor sled for receiving sample vessels with different dimensions and contact surfaces facing the conveyor sled, conversion measures on the belt conveyor are omitted if different sample vessels are to be handled with it.
  • the belt conveyor also enables the automatic device to be expanded by a further automatic device, so that, for example, two such automatic devices can be connected to one another and can replace filled or unfilled sample containers and thus supplement one already existing automatic device to another automatic device is possible.
  • the device has a base plate, within the outer dimensions of which the handling device can preferably be moved three-dimensionally.
  • the conveyor area of the belt conveyor can extend beyond the outer dimensions of the base plate, so that sample vessels can thus be transported beyond the outer dimensions of the base plate and thus, for example, to a buffer store provided outside the base plate or to another automatic device for carrying out chemical processes or biological processes, as has already been explained above.
  • the belt conveyor provided according to the invention can convey sample vessels between a stacking device for sample vessels and the handling device provided on the automatic device.
  • This stacking device is preferably arranged outside the base plate of the device, but the belt conveyor can also convey sample vessels between at least two devices arranged one after the other for the automatic implementation of biological or chemical processes.
  • the belt conveyor has a conveyor slide for receiving sample vessels with different dimensions and differently designed contact surfaces facing the conveyor slide.
  • the end positions of the conveyor carriage that can be reached by the belt conveyor can be set in a sensor-monitored manner. On the one hand, the end positions of the conveyor carriage can be adjusted and thus adjusted.
  • the end positions can be monitored via sensors in the form of, for example, light barriers, inductive or capacitive sensors or the like, and the program control can monitor the attainment of these settings, so that it interrupts the supply of current to the drive motor of the belt conveyor after the end positions have been reached.
  • Monitoring of the occupancy of the conveyor sled with conveyed material in the form of a sample vessel or the like is also provided, for which purpose a light barrier, which monitors the upper side of the conveyor sled, is used to determine whether a sample vessel is in contact or not and thus the method of the conveyor sled is released or not.
  • the belt conveyor provided according to the invention therefore allows the automatic device to be connected to one or more stacking devices or other already existing automatic devices, which can be specialized and for this purpose, for example, can have a plurality of thermal cyclers, while an associated further automatic device can in turn be specialized in another way , namely for example for the preparation of the chemical or biological processes, for example for the filling of microtiter plates.
  • 1 shows an automatic device with two thermal cyclers and two pipette holders, as well as a belt conveyor and a stacking device for storing microtiter plates
  • 2 shows an embodiment with two automatic devices arranged one behind the other, which are connected to one another via a belt conveyor and have a stacking device as an intermediate store;
  • Figure 3 is a side view of a belt conveyor.
  • Fig. 4 is a top view of the belt conveyor of Fig. 3;
  • Fig. 5 is a view of the receiving frame of the belt conveyor
  • Fig. 6 is a view of the tread for a toothed belt of the belt conveyor.
  • FIG. 7A, B are views of the conveyor sled of the belt conveyor.
  • FIG. 1 of the drawing shows, on the basis of a schematic and perspective illustration, a device 1 for carrying out chemical or biological processes or reactions in sample vessels.
  • a belt conveyor 2 is also arranged on the device 1 and is functionally coupled to a stacking device 3 arranged outside the working area of the device 1.
  • the stacking device 3 is used to hold empty or already filled sample containers in the form of, for example, microtiter plates.
  • the stacking device 3 shown in FIG. 1 can be, for example, an intermediate store in the form of a magazine, in which the microtiter plates are stacked one above the other and can be conveyed downwards by a separating device in the form of, for example, a lifting device and there onto the 3 can be placed in more detail with reference to Fig. 3 conveyor sled of the belt conveyor 2.
  • two or more of these stacking devices can also be provided next to one another, which are functionally coupled to one another and permit the transport of microtiter plates on the conveyor slides of the belt conveyor 2.
  • the device 1 has a rectangular base plate 4 with two end edges 5 and a front and rear longitudinal edge 6.
  • a rear wall 7 is arranged on the base plate 4 on the rear longitudinal edge 6.
  • a horizontal rail 8 is provided in the rear wall 7, parallel to the rear longitudinal edge 6 of the base plate 4, on which two robot arms 9 are arranged to be movable in the longitudinal direction of the rail 8 (double arrow 10, X direction).
  • the robot arms 9 are each straight, rigid arms, which are arranged parallel to the front edges 5 of the base plate 4. They are thus perpendicular to the plane of the rear wall 7.
  • a longitudinal slot 11 is provided on each of the robot arms 9, an actuating arm arranged vertically to the base plate 4 extending through the longitudinal slots 11.
  • the actuating arms 12 can each be moved along a rail (not shown) running in the longitudinal direction (Y direction) of the robot arms 9. In addition, the actuating arms 12 can also be moved in the vertical direction (Z direction). A pipetting tip 13 is attached to one of the two actuating arms 12 and a fork-shaped gripping device 14 is attached to the other actuating arm 12. Microtiter plates can be picked up and moved with the gripping device 14.
  • thermocycler devices 15 are arranged, which are shown schematically with their receiving area 16 and their lids 17 in the opened state.
  • two pipetting holders 18 are formed on the base plate 4, on which the microtiter plates can be placed.
  • the on the holders 18 Set microtiter plates are precisely aligned with respect to the base plate 4, so that the location of the individual vessels formed on the microtiter plates is precisely defined and can be controlled precisely by the robot arms.
  • the pipetting holders 18 define pipetting stations at which the pipetting can be carried out by means of the pipetting tip 13.
  • the base plate 4 also has a chemical reservoir 19 with a plurality of vessels with various chemicals open at the top and a stacking device 20 for holding a plurality of microtiter plates.
  • the stacking device 20 is formed by a plurality of webs 21 projecting perpendicularly from the rear wall 7.
  • the belt conveyor 2 can be integrated into the base plate 4 in such a way that the top of the belt conveyor 2 is at the same height as the top of the base plate 4 and thus the belt conveyor 2 is an integral part of the device 1.
  • the belt conveyor 2 which can be seen in more detail with reference to FIG. 3 of the drawing, is connected to a stacking device 3 in the form of a magazine and can transport microtiter plates from this into the working area of the robot arms 9, so that these can then be moved, for example, by the the robot arm 9 provided with the gripping device 14 can be removed from the belt conveyor 2 and transported further within the entire base plate 4 in the working area of the robot arms 9.
  • a microtiter plate originating from the stacking device 3 and which is already filled with the samples to be examined is therefore brought with the belt conveyor 2 into the travel area of the robot arms 9 and is picked up there by the gripping device 14 and placed on the pipette holder 18.
  • the robot arm 9 provided with the pipette tip 13 is then used to extract chemicals from the chemical reservoir 19.
  • chemicals are pipetted into the microtiter plate and then placed on the receiving area 16 of the thermal cycler 15 by the gripping device 14 after completion of the pipetting process.
  • the motor-driven covers 17 of the respective thermocycler device 15 are automatically closed and the corresponding method can begin.
  • the lids 17 open again automatically and the covering mat can be removed via the gripping device 14 and placed on the base plate 4.
  • the device 1 shown on the left in the drawing has four pipetting holders 18, onto which 9 microtiter plates can be placed over the robot arm equipped with the gripping device 14, so that chemicals from the chemical reservoir 19 in can be placed over the pipetting tip 13 the microtiter plates can be inserted.
  • this device it is also possible, for example, to provide a further robot arm 9 (not shown in more detail) with a further pipetting tip 13, so that 14 microtiter plates are placed on the pipetting holder 18 via the gripper, and then two microtiter plates with reagents are simultaneously applied via the two pipetting tips be filled from the chemical reservoir 19.
  • microtiter plates then filled with the samples to be examined and with the reagents can be temporarily stored in the stacking device 20 provided in the rear wall 7 by means of the gripper 14. It is also possible to transport the microtiter plates filled in this way back via the belt conveyor 2 into the stacking device 3, where they are stored temporarily until they are transferred via the belt conveyor 2, the gripper 14 and the further belt conveyor 23 to the one shown in the drawing in FIG right half shown further device 1 can be transported. Both belt conveyors 2 and 23 are integrated in the respective base plates 4 in the manner described above and ensure that the different microtiter plates are transported via the appropriately designed conveyor slides.
  • the device 1 shown in the right half of the drawing in the embodiment shown has only one robot arm 9 with a gripper 14 which can remove the microtiter plates filled with sample substances and reagents from the belt conveyor 23 and insert them into the four thermal cyclers shown. A chemical or biological process then takes place in these, as has already been explained above.
  • FIG. 2 of the drawing shows that the device 1 shown in the left half has been designed such that it can be used to carry out a pipetting process largely simultaneously at the largest possible number of microtiter plates, while the device 1 shown in the right half of the drawing was trained to carry out the largest possible number of chemical or biological processes or reactions.
  • the belt conveyor 23 is used to transport prepared microtiter plates to the device 1, which is used to carry out the chemical or biological reactions, while the belt conveyor 2 is used to transport sample vessels to be prepared.
  • Fig. 3 of the drawing shows a side view of an embodiment of the belt conveyor 2, 23 according to the invention.
  • the belt conveyor has a receiving frame 24 which can be inserted integrally into the base plate 4 of the device 1, so that the belt conveyor 3, 23 can also be supplemented later.
  • the receiving frame 24 is characterized by an overall elongated configuration, so that the travel path in the X direction (double arrow 25) can be adapted by changing the longitudinal extent of the receiving frame 24.
  • a deflecting roller 26 which is rotatably mounted there and a drive roller 27 which is also rotatably mounted there at the opposite end region of the receiving frame 24, the two rollers in the embodiment shown being provided with a toothed outer profile since the one on the receiving frame 24 Conveyor slide 28, which is displaceable in the axial longitudinal direction, is actuated via a toothed belt 29.
  • the drive roller 27 is driven by a drive motor 30 which is detachably flanged underneath the receiving frame 24 and to which a transmission can be connected, via a schematically illustrated drive belt 31.
  • a vibration absorber 33 in the form of, for example, an elastomer for vibration decoupling of the receiving frame 24 from the receiving frame 32.
  • a toothed belt 29 and a belt drive 31 for actuating the conveyor carriage 28 have been shown in the illustrated embodiment, it is readily apparent to the person skilled in the art that instead of the belt drive 31, for example, a motor 30 directly flanged to the drive roller 27 or another one Drive concept could be used.
  • the receiving frame 24 has elongated holes 34 in which adjustable sensors can be arranged, by means of which the reaching of the end position of the conveyor carriage 28 can be determined, the signals of which can be evaluated by a control device for the devices 1, and which after reaching the preset end position, the power supply to the drive motor 30 is interrupted.
  • the two belts 29, 35 run on a tread 36 shown in FIG. 6, which is detachably attached to the upper side of the receiving frame 24 and can, for example, have a coating which reduces the sliding resistance between the belts 29, 35 and the tread 36.
  • the arrangement of the running surface 36 (FIG. 6) on the upper side of the receiving frame 24, which is shown in FIG. 5, is selected such that elongated holes provided for the arrangement and setting of sensors for determining the setting of the travel path of the conveyor carriage 28 34 remain free both on the side wall of the receiving frame 24 and in the area of the upper side and the running surface 36.
  • Fig. 7 of the drawing shows in Fig. 7A in a view from above the conveyor carriage 28 of the belt conveyor 3 according to the invention.
  • the conveyor slide 28 has an overall rectangular configuration and is designed for receiving conveyed goods in the form of, for example, microtiter plates with different contact surfaces facing the conveyor slide 28.
  • the conveyor carriage 28 has on its upper side 37 facing the material to be conveyed different profiles in the form of grids and the like, which correspond to surface and shape-complementary grids on the contact surface of the material to be conveyed, so that a safe transport of the material to be conveyed Conveyor carriage 28 is possible without the material to be conveyed, for example in the form of the microtiter plates, falling from the conveyor carriage 28 during movement along the running surface 36.
  • An example of such a grid is shown in FIG. 7B in the form of the inclined surfaces 38, which merge into a recess 39 into which a projection on the contact surface of a microtiter plate facing the conveyor slide 28 can engage.
  • the inclined surface 38 simultaneously act as centering surfaces, so that a microtiter plate transported from the gripping device 14 of a robot arm 9 to the conveyor slide 28 can be placed centered on the conveyor carriage 28 by the robot arm.
  • the conveyor carriage 28 also has an elongated hole 40 on its top through which a light beam from a light barrier arranged in the receiving frame 24 can pass. If a sample vessel lies on the conveyor carriage 28, the light beam is reflected there and falls back onto a receiver cell of the light barrier, whereby it can be determined whether or not material to be conveyed rests on the conveyor carriage 28, which can be evaluated to control the movement of the conveyor carriage 28 can.
  • the running surface 36 shown in FIG. 6 also has two elongated holes 41 which are formed in the region of the end positions of the conveyor slide 28 above the running surface 36.
  • the belt conveyor 2, 23 can be integrated into the base plate 4 of the device in such a way that the top of the belt conveyor 2, 23 is at the same height as the top of the base plate 4 and thus the belt conveyor 2, 23 is more integral Is part of the device.
  • This integration achieves a space-saving structure of the device and, on the other hand, the effort for the movement of the handling device 9 can be reduced.
  • the level with the base plate 4 integration of the belt conveyor 3, 23 namely ensures a flat contour of the Manual handling device 9 traversable travel area, which reduces the teach-in effort when programming the travel paths of the handling device 9.
  • the reliability of the device is also increased, since in the event of a possible malfunction of the belt conveyor 2, 23, a sample container transported with it is shifted onto the base plate at the same height and does not fall off the belt conveyor onto the base plate.
  • the device equipped with the belt conveyor is therefore characterized by an extremely high degree of variability, since, for example, two devices for automatically carrying out a chemical or biological process can be coupled to the belt conveyor. It is also possible to connect a plurality of such devices to one another via a plurality of belt conveyors, each individual device fulfilling a highly specialized task and by coupling the plurality of devices achieving that the throughput of the sample vessels to be processed can be increased considerably.
  • intermediate storage in the form of stacking devices between the individual devices, which are connected to belt conveyors and are designed for the intermediate storage of, for example, microtiter plates, so that the microtiter plates to be processed are continuously transported through them thus created line of several devices arranged one behind the other for the automatic preparation and implementation of chemical or biological processes was created.

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  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif permettant la mise en oeuvre automatique de procédés chimiques ou biologiques dans des récipients d'échantillons, notamment pour séquencer et amplifier des séquences d'acide nucléique. Ledit dispositif comprend au moins un dispositif permettant de préparer et/ou de mettre les procédés en oeuvre et au moins un dispositif de manipulation (9) pour manipuler les récipients d'échantillons et une bande transporteuse (2 ;23) pour alimenter le dispositif de manipulation en récipients d'échantillons (9) et/ou les en évacuer. La zone de transport de la bande transporteuse (2 ;23) s'étend au-delà des dimensions extérieures d'une plaque de base (4) du dispositif et la bande transporteuse (2) présente un chariot de transport (28) pour recevoir les récipients d'échantillons avec des surfaces de contact de différentes dimensions et qui font face au chariot de transport (28).
PCT/EP2001/003975 2000-04-08 2001-04-06 Dispositif pour la mise en oeuvre de procedes chimiques ou biologiques WO2001077689A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001256264A AU2001256264A1 (en) 2000-04-08 2001-04-06 Device for implementing chemical or biological methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE20006548U DE20006548U1 (de) 2000-04-08 2000-04-08 Vorrichtung zum Durchführen von chemischen bzw. biologischen Verfahren
DE20006548.3 2000-04-08

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Publication Number Publication Date
WO2001077689A1 true WO2001077689A1 (fr) 2001-10-18

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DE (1) DE20006548U1 (fr)
WO (1) WO2001077689A1 (fr)

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EP1615037A1 (fr) * 2004-07-06 2006-01-11 Boehringer Mannheim Gmbh Dispositif pour la manipulation de liquides avec une pluralité d'outils de transfert
CH696030A5 (de) * 2003-03-21 2006-11-30 Tecan Trading Ag Vorrichtung und deren Verwendung zum Manipulieren von Proben.
EP2755033A3 (fr) * 2013-01-09 2017-12-27 Hamilton Bonaduz AG Système de traitement d'échantillons avec dispositif de dosage et thermocycleur
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CH696030A5 (de) * 2003-03-21 2006-11-30 Tecan Trading Ag Vorrichtung und deren Verwendung zum Manipulieren von Proben.
EP1615037A1 (fr) * 2004-07-06 2006-01-11 Boehringer Mannheim Gmbh Dispositif pour la manipulation de liquides avec une pluralité d'outils de transfert
EP2755033A3 (fr) * 2013-01-09 2017-12-27 Hamilton Bonaduz AG Système de traitement d'échantillons avec dispositif de dosage et thermocycleur
US10294522B2 (en) 2013-01-09 2019-05-21 Hamilton Bonaduz Ag Sample handling system with dosing device and thermal cycler
EP2755033B1 (fr) 2013-01-09 2019-05-22 Hamilton Bonaduz AG Système de traitement d'échantillons avec dispositif de dosage et thermocycleur
EP3564680A1 (fr) * 2013-01-09 2019-11-06 Hamilton Bonaduz AG Système de traitement des échantillons pourvu de dispositif de dosage et thermocycleur
GB2615525A (en) * 2022-02-04 2023-08-16 Automata Tech Limited A workbench system

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AU2001256264A1 (en) 2001-10-23

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