WO2001077686A3 - Cellular calcium responce for diagnosis of alzheimer's disease - Google Patents

Cellular calcium responce for diagnosis of alzheimer's disease Download PDF

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Publication number
WO2001077686A3
WO2001077686A3 PCT/US2001/011060 US0111060W WO0177686A3 WO 2001077686 A3 WO2001077686 A3 WO 2001077686A3 US 0111060 W US0111060 W US 0111060W WO 0177686 A3 WO0177686 A3 WO 0177686A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
ratio index
individual
alzheimer
responce
Prior art date
Application number
PCT/US2001/011060
Other languages
French (fr)
Other versions
WO2001077686A2 (en
Inventor
Rene Etcheberrigaray
Seetha Bhagavan
Barry Bank
Daniel L Alkon
Original Assignee
Neurologic Inc
Rene Etcheberrigaray
Seetha Bhagavan
Barry Bank
Daniel L Alkon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurologic Inc, Rene Etcheberrigaray, Seetha Bhagavan, Barry Bank, Daniel L Alkon filed Critical Neurologic Inc
Priority to AU2001255234A priority Critical patent/AU2001255234A1/en
Publication of WO2001077686A2 publication Critical patent/WO2001077686A2/en
Publication of WO2001077686A3 publication Critical patent/WO2001077686A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

A method of diagnosing Alzheimer's disease in an individual comprises obtaining data comprising a first raw percentage of cells of the individual responding when contacted by a first modulator of a first calcium signaling pathway element, and a second raw percentage of cells of the individual responding when contacted by a second modulator of a second calcium signaling pathway element, dividing the first raw percentage by the second raw percentage to provide a ratio index, comparing the ratio index to a pre-determined threshold diagnostic value, and scoring the individual as AD positive if the ratio index exceeds the threshold diagnostic value, and as AD negative if the ratio index does not exceed the threshold diagnostic value.
PCT/US2001/011060 2000-04-05 2001-04-05 Cellular calcium responce for diagnosis of alzheimer's disease WO2001077686A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001255234A AU2001255234A1 (en) 2000-04-05 2001-04-05 Cellular calcium responce for diagnosis of alzheimer's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19462600P 2000-04-05 2000-04-05
US60/194,626 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077686A2 WO2001077686A2 (en) 2001-10-18
WO2001077686A3 true WO2001077686A3 (en) 2002-08-29

Family

ID=22718298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011060 WO2001077686A2 (en) 2000-04-05 2001-04-05 Cellular calcium responce for diagnosis of alzheimer's disease

Country Status (2)

Country Link
AU (1) AU2001255234A1 (en)
WO (1) WO2001077686A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5598200B2 (en) 2010-09-16 2014-10-01 ソニー株式会社 Data processing apparatus, data processing method, and program
CN116469540B (en) * 2023-03-30 2023-11-14 北京透彻未来科技有限公司 Denoising method and system based on double threshold values

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025872A1 (en) * 1993-05-03 1994-11-10 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cell test for alzheimer's disease
WO1996010182A1 (en) * 1994-09-26 1996-04-04 The Government Of The United States Of America, Re Cell tests and diagnostic index for alzheimer's disease
WO1999024830A1 (en) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Method for diagnosing alzheimer's disease
WO1999058981A2 (en) * 1998-05-11 1999-11-18 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Diagnostic tests for alzheimer's disease

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025872A1 (en) * 1993-05-03 1994-11-10 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cell test for alzheimer's disease
WO1996010182A1 (en) * 1994-09-26 1996-04-04 The Government Of The United States Of America, Re Cell tests and diagnostic index for alzheimer's disease
WO1999024830A1 (en) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Method for diagnosing alzheimer's disease
WO1999058981A2 (en) * 1998-05-11 1999-11-18 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Diagnostic tests for alzheimer's disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ETCHEBERRIGARAY R ET AL: "IONIC AND SIGNAL TRANSDUCTION ALTERATIONS IN ALZHEIMER'S DISEASE RELEVANCE OF STUDIES ON PERIPHERAL CELLS", MOLECULAR NEUROBIOLOGY, HUMANA PRESS, US, vol. 20, no. 2/3, 1999, pages 93 - 109, XP001009411, ISSN: 0893-7648 *

Also Published As

Publication number Publication date
AU2001255234A1 (en) 2001-10-23
WO2001077686A2 (en) 2001-10-18

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