WO2001077381A3 - Dna analysis for determination of ancestry - Google Patents

Dna analysis for determination of ancestry Download PDF

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Publication number
WO2001077381A3
WO2001077381A3 PCT/GB2001/001633 GB0101633W WO0177381A3 WO 2001077381 A3 WO2001077381 A3 WO 2001077381A3 GB 0101633 W GB0101633 W GB 0101633W WO 0177381 A3 WO0177381 A3 WO 0177381A3
Authority
WO
WIPO (PCT)
Prior art keywords
sequences
human
ancestry
mutations
mtdna
Prior art date
Application number
PCT/GB2001/001633
Other languages
French (fr)
Other versions
WO2001077381A2 (en
Inventor
Bryan Clifford Sykes
Original Assignee
Isis Innovation
Bryan Clifford Sykes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Bryan Clifford Sykes filed Critical Isis Innovation
Priority to AU50490/01A priority Critical patent/AU5049001A/en
Publication of WO2001077381A2 publication Critical patent/WO2001077381A2/en
Publication of WO2001077381A3 publication Critical patent/WO2001077381A3/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of determining probable ancestry of a human individual to a dead human female ancestor is disclosed. A sample is taken from a human whose ancestry is to be determined, mitochondial DNA (mtDNA) extracted therefrom and sequenced. A portion of this mtDNA sequence is then compared with other 'comparison' mtDNA sequences in the same region to determine the differences (or mutations) between these two sequences. In particular, the sequence from a human is compared with a reference sequence and the positions of the mutations determined. Sequences having the same mutations are likely to be related, and thus an indication of probable ancestryy can be determined. A database of sequences can be produced, where the sequences are related to each other by means of their mutations, and this can be used to generate a gene tree. An individuals' position in that gene tree, determined by the nature of the mutation, can then indicate ancestry, in particular to a female ancestor who lived many thousands of years ago. In particular, it has been found that virtually all human mtDNA sequences can be traced back to only a few (6-8) female ancestors.
PCT/GB2001/001633 2000-04-11 2001-04-11 Dna analysis for determination of ancestry WO2001077381A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50490/01A AU5049001A (en) 2000-04-11 2001-04-11 Dna analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0008899.7A GB0008899D0 (en) 2000-04-11 2000-04-11 DNA analysis
GB0008899.7 2000-04-11

Publications (2)

Publication Number Publication Date
WO2001077381A2 WO2001077381A2 (en) 2001-10-18
WO2001077381A3 true WO2001077381A3 (en) 2002-08-01

Family

ID=9889684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001633 WO2001077381A2 (en) 2000-04-11 2001-04-11 Dna analysis for determination of ancestry

Country Status (3)

Country Link
AU (1) AU5049001A (en)
GB (2) GB0008899D0 (en)
WO (1) WO2001077381A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003282562A1 (en) * 2002-08-02 2004-02-25 David Atlan Method and system for finding mutations in dna sequences and interpreting their consequences
AU2003265572A1 (en) * 2002-08-19 2004-03-03 Dnaprint Genomics, Inc. Compositions and methods for inferring ancestry
US20080189047A1 (en) * 2006-11-01 2008-08-07 0752004 B.C. Ltd. Method and system for genetic research using genetic sampling via an interactive online network
GB0707790D0 (en) * 2007-04-23 2007-05-30 Oxford Ancestors Ltd Nucleic acid-containing media

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BURCKHARDT F ET A.: "HvrBase: compilation of mtDNA control region sequences from primates", NUCLEIC ACIDS RESEARCH, vol. 27, no. 1, 1999, pages 138 - 142, XP002197756 *
CORTE-REAL H B S M ET AL.: "Genetic diversity in the Iberian Peninsula determined from mitochondrial sequence analysis", ANNALS OF HUMAN GENETICS, vol. 60, 1996, pages 331 - 350, XP008002086 *
HELGASON A ET AL.: "mDNA and the origin of the islanders: Deciphering Signals of recent population history", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 66, March 2000 (2000-03-01), pages 999 - 1003, XP001064616 *
HELGASON A ET AL.: "mtDNA and the islands of the north Atlantic: Estimating the proportions of Norse and Gaelic Ancestry", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 68, March 2001 (2001-03-01), pages 723 - 737, XP001064617 *
PULT I ET AL.: "Mitochondrial DNA sequences from Switzerland reveal striking homologeneity of European populations", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, vol. 375, 1994, pages 837 - 840, XP008002078 *
RICHARDS M B ET AL: "PHYLOGEOGRAPHY OF MITOCHONDRIAL DNA IN WESTERN EUROPE", ANNALS OF HUMAN GENETICS, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 62, no. PART 3, 1998, pages 241 - 260, XP000911101, ISSN: 0003-4800 *
RICHARDS M ET AL.: "Paleolithic and neolithic lineages in the European mitochondrial gene pool", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 59, 1996, pages 185 - 203, XP000802084 *
SYKES B: "THE MOLECULAR GENETICS OF EUROPEAN ANCESTRY", PHILOSOPHICAL TRANSACTIONS. ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES, ROYAL SOCIETY, LONDON, GB, vol. 354, no. 1379, 1999, pages 131 - 139, XP000910529, ISSN: 0962-8436 *
WALLACE D C ET AL.: "Mitochondrial DNA variation in human evolution and disease", GENE, vol. 238, 1999, pages 211 - 230, XP002197755 *

Also Published As

Publication number Publication date
AU5049001A (en) 2001-10-23
GB0109144D0 (en) 2001-05-30
GB0008899D0 (en) 2000-05-31
WO2001077381A2 (en) 2001-10-18
GB2364311A (en) 2002-01-23

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