WO2001075097A3 - Improvements to ribosome display - Google Patents
Improvements to ribosome display Download PDFInfo
- Publication number
- WO2001075097A3 WO2001075097A3 PCT/GB2001/001319 GB0101319W WO0175097A3 WO 2001075097 A3 WO2001075097 A3 WO 2001075097A3 GB 0101319 W GB0101319 W GB 0101319W WO 0175097 A3 WO0175097 A3 WO 0175097A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- specific binding
- oxidised
- optionally
- ratio
- combination
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001239444A AU2001239444B2 (en) | 2000-03-31 | 2001-03-26 | Improvements to ribosome display |
EP01914058A EP1268766B1 (en) | 2000-03-31 | 2001-03-26 | Improvements to ribosome display |
CA002402452A CA2402452A1 (en) | 2000-03-31 | 2001-03-26 | Improvements to ribosome display |
DE60115405T DE60115405T2 (en) | 2000-03-31 | 2001-03-26 | IMPROVEMENTS RELATING TO RIBOSOME COMPLEXES AS SELECTION PARTICLES |
JP2001572971A JP2003529369A (en) | 2000-03-31 | 2001-03-26 | Improved ribosome display |
AU3944401A AU3944401A (en) | 2000-03-31 | 2001-03-26 | Improvements to ribosome display |
AT01914058T ATE311444T1 (en) | 2000-03-31 | 2001-03-26 | IMPROVEMENTS IN RIBOSOME COMPLEXES AS SELECTION PARTICLES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19380200P | 2000-03-31 | 2000-03-31 | |
US60/193,802 | 2000-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001075097A2 WO2001075097A2 (en) | 2001-10-11 |
WO2001075097A3 true WO2001075097A3 (en) | 2002-01-03 |
Family
ID=22715061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/001319 WO2001075097A2 (en) | 2000-03-31 | 2001-03-26 | Improvements to ribosome display |
Country Status (11)
Country | Link |
---|---|
US (2) | US7074557B2 (en) |
EP (1) | EP1268766B1 (en) |
JP (1) | JP2003529369A (en) |
AT (1) | ATE311444T1 (en) |
AU (2) | AU3944401A (en) |
CA (1) | CA2402452A1 (en) |
DE (1) | DE60115405T2 (en) |
DK (1) | DK1268766T3 (en) |
ES (1) | ES2253358T3 (en) |
GB (1) | GB2365429B (en) |
WO (1) | WO2001075097A2 (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT985032E (en) | 1997-05-28 | 2004-02-27 | Discerna Ltd | RIBOSOMIC COMPLEXES AS SELECTIVE PARTICLES FOR IN VITRO PRESENTATION AND EVOLUTION OF PROTEINS |
US20120202710A1 (en) * | 2003-09-09 | 2012-08-09 | Integrigen, Inc. | Methods and compositions for generation of germline human antibody genes |
US20070111237A1 (en) * | 2005-09-14 | 2007-05-17 | Maurizio Zanetti | Process for identifying antigenized antibodies using ribosome cell free expression system |
US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
WO2009018438A1 (en) * | 2007-07-31 | 2009-02-05 | Cornell Research Foundation, Inc. | Protein discovery using intracellular ribosome display |
US9879252B2 (en) | 2007-06-13 | 2018-01-30 | Cornell Research Foundation, Inc. | Protein discovery using intracellular ribosome display |
US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
JP5924937B2 (en) | 2008-07-25 | 2016-05-25 | エックス−ボディ インコーポレイテッド | Protein screening method |
WO2010036860A2 (en) * | 2008-09-26 | 2010-04-01 | Wyeth Llc | Compatible display vector systems |
WO2010036856A2 (en) * | 2008-09-26 | 2010-04-01 | Wyeth Llc | Compatible display vector systems |
US8916504B2 (en) * | 2008-09-30 | 2014-12-23 | Abbvie Inc. | Methods of RNA display |
US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
US20100158822A1 (en) * | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
US20100247590A1 (en) * | 2009-03-30 | 2010-09-30 | Johnson & Johnson | Peptide-Based Systems For Delivery Of Cosmetic Agents |
US8481678B2 (en) | 2009-03-30 | 2013-07-09 | E I Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
WO2011111832A1 (en) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | Method for selecting polypeptide sequence, metal oxide or silicon containing compound binding peptide and use thereof |
EP2655416A1 (en) | 2010-12-20 | 2013-10-30 | Medimmune Limited | Anti-il-18 antibodies and their uses |
DE102010056289A1 (en) | 2010-12-24 | 2012-06-28 | Geneart Ag | Process for the preparation of reading frame correct fragment libraries |
JP5948673B2 (en) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | COMPOSITION FOR PROTEIN SYNTHESIS WITH REDUCED LIPO POLUCHIsaccharide CONTENT AND METHOD FOR PRODUCING PROTEIN USING THE COMPOSITION |
WO2012161227A1 (en) | 2011-05-23 | 2012-11-29 | 独立行政法人理化学研究所 | Nucleic acid construct, nucleic acid-protein complex, and use thereof |
RU2689674C2 (en) | 2012-10-15 | 2019-05-28 | Медиммьюн Лимитед | Beta-amyloid antibodies |
US9896685B2 (en) | 2013-04-25 | 2018-02-20 | Sutro Biopharma, Inc. | Use of LAMBDA-GAM protein in ribosomal display technology |
EP2989239B1 (en) * | 2013-04-25 | 2018-07-04 | Sutro Biopharma, Inc. | Selection of fab fragments using ribosomal display technology |
WO2014189768A1 (en) * | 2013-05-19 | 2014-11-27 | The Board Of Trustees Of The Leland | Devices and methods for display of encoded peptides, polypeptides, and proteins on dna |
WO2015048391A1 (en) | 2013-09-27 | 2015-04-02 | The Board Of Trustees Of The University Of Illinois | Method and kit for generating high affinity binding agents |
EP3102245B1 (en) | 2014-02-05 | 2021-09-08 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
CN115043943A (en) | 2015-05-15 | 2022-09-13 | 综合医院公司 | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
JP2019500899A (en) | 2015-11-23 | 2019-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Cellular RNA tracking and manipulation through nuclear delivery of CRISPR / Cas9 |
WO2019204828A1 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Fusion proteins and fusion ribonucleic acids for tracking and manipulating cellular rna |
US11174479B2 (en) | 2018-08-13 | 2021-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for display of encoded peptides, PolyPeptides, and proteins on DNA |
AU2019342017A1 (en) | 2018-09-18 | 2021-05-13 | Merrimack Pharmaceuticals, Inc. | Anti-TNFR2 antibodies and uses thereof |
EP3930846A1 (en) | 2019-03-01 | 2022-01-05 | Merrimack Pharmaceuticals, Inc. | Anti-tnfr2 antibodies and uses thereof |
WO2022167396A1 (en) | 2021-02-02 | 2022-08-11 | Biocopy Gmbh | Method for identifying emerging pathogen mutations enabling host cell entry and immune evasion |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994006920A1 (en) * | 1992-09-22 | 1994-03-31 | Medical Research Council | Recombinant viruses displaying a nonviral polypeptide on their external surface |
WO1994010329A1 (en) * | 1992-10-29 | 1994-05-11 | Rutgers University | Rna packaging system |
WO1998048008A1 (en) * | 1997-04-23 | 1998-10-29 | Plueckthun Andreas | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
WO1998054312A1 (en) * | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
WO1999011777A1 (en) * | 1997-09-03 | 1999-03-11 | Biovation Limited | Methods for protein screening |
WO1999058661A1 (en) * | 1998-05-08 | 1999-11-18 | Diatech Pty. Ltd. | Continuous in vitro evolution |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2067194C (en) * | 1989-10-05 | 2003-03-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5677124A (en) * | 1996-07-03 | 1997-10-14 | Ambion, Inc. | Ribonuclease resistant viral RNA standards |
US5939262A (en) * | 1996-07-03 | 1999-08-17 | Ambion, Inc. | Ribonuclease resistant RNA preparation and utilization |
-
2001
- 2001-03-26 ES ES01914058T patent/ES2253358T3/en not_active Expired - Lifetime
- 2001-03-26 CA CA002402452A patent/CA2402452A1/en not_active Abandoned
- 2001-03-26 GB GB0107543A patent/GB2365429B/en not_active Expired - Lifetime
- 2001-03-26 AT AT01914058T patent/ATE311444T1/en active
- 2001-03-26 DE DE60115405T patent/DE60115405T2/en not_active Expired - Lifetime
- 2001-03-26 AU AU3944401A patent/AU3944401A/en active Pending
- 2001-03-26 JP JP2001572971A patent/JP2003529369A/en active Pending
- 2001-03-26 US US09/817,661 patent/US7074557B2/en not_active Expired - Lifetime
- 2001-03-26 WO PCT/GB2001/001319 patent/WO2001075097A2/en active IP Right Grant
- 2001-03-26 EP EP01914058A patent/EP1268766B1/en not_active Expired - Lifetime
- 2001-03-26 DK DK01914058T patent/DK1268766T3/en active
- 2001-03-26 AU AU2001239444A patent/AU2001239444B2/en not_active Expired
-
2006
- 2006-02-23 US US11/362,309 patent/US20060177862A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994006920A1 (en) * | 1992-09-22 | 1994-03-31 | Medical Research Council | Recombinant viruses displaying a nonviral polypeptide on their external surface |
WO1994010329A1 (en) * | 1992-10-29 | 1994-05-11 | Rutgers University | Rna packaging system |
WO1998048008A1 (en) * | 1997-04-23 | 1998-10-29 | Plueckthun Andreas | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
WO1998054312A1 (en) * | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
WO1999011777A1 (en) * | 1997-09-03 | 1999-03-11 | Biovation Limited | Methods for protein screening |
WO1999058661A1 (en) * | 1998-05-08 | 1999-11-18 | Diatech Pty. Ltd. | Continuous in vitro evolution |
Non-Patent Citations (3)
Title |
---|
HANES JOZEF ET AL: "Comparison of Escherichia coli and rabbit reticulocyte ribosome display systems.", FEBS LETTERS, vol. 450, no. 1-2, 30 April 1999 (1999-04-30), pages 105 - 110, XP002178365, ISSN: 0014-5793 * |
HWANG DUK-JU ET AL: "Expression of tobacco mosaic virus coat protein and assembly of pseudovirus particles in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 91, no. 19, 1994, 1994, pages 9067 - 9071, XP002178364, ISSN: 0027-8424 * |
MAKEYEV EUGENY V ET AL: "Cell-free immunology: Construction and in vitro expression of a PCR-based library encoding a single-chain antibody repertoire.", FEBS LETTERS, vol. 444, no. 2-3, 12 February 1999 (1999-02-12), pages 177 - 180, XP002178366, ISSN: 0014-5793 * |
Also Published As
Publication number | Publication date |
---|---|
GB2365429A (en) | 2002-02-20 |
DK1268766T3 (en) | 2006-04-10 |
DE60115405D1 (en) | 2006-01-05 |
US7074557B2 (en) | 2006-07-11 |
AU2001239444B2 (en) | 2004-10-07 |
GB2365429B (en) | 2002-07-24 |
EP1268766B1 (en) | 2005-11-30 |
EP1268766A2 (en) | 2003-01-02 |
DE60115405T2 (en) | 2006-08-03 |
AU3944401A (en) | 2001-10-15 |
US20020076692A1 (en) | 2002-06-20 |
CA2402452A1 (en) | 2001-10-11 |
GB0107543D0 (en) | 2001-05-16 |
ATE311444T1 (en) | 2005-12-15 |
JP2003529369A (en) | 2003-10-07 |
WO2001075097A2 (en) | 2001-10-11 |
US20060177862A1 (en) | 2006-08-10 |
ES2253358T3 (en) | 2006-06-01 |
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