WO2001074392A1 - Preparations sous forme de microspheres contenant un antagoniste de recepteur de neurokinine 1 - Google Patents
Preparations sous forme de microspheres contenant un antagoniste de recepteur de neurokinine 1 Download PDFInfo
- Publication number
- WO2001074392A1 WO2001074392A1 PCT/JP2001/002530 JP0102530W WO0174392A1 WO 2001074392 A1 WO2001074392 A1 WO 2001074392A1 JP 0102530 W JP0102530 W JP 0102530W WO 0174392 A1 WO0174392 A1 WO 0174392A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vomiting
- receptor antagonist
- neurokinin
- preparations containing
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des préparations sous forme de microsphères qui contiennent un antagoniste de récepteur de neurokinine 1 et un polymère pratiquement non hydro-soluble, biocompatible et biodégradable, et qui sont très utiles en médecine clinique, grâce à leur capacité d'inhiber efficacement les vomissements aigus, les vomissements tardifs et les vomissements anticipés provoqués par l'administration de substances vomitives (produits chimiothérapeutiques contre le cancer, analgésiques opioïdes, etc.), par la radiothérapie et analogue, et d'empêcher les effets secondaires des vomissements dans la chimiothérapie du cancer et la radiothérapie. Les vomissements peuvent être efficacement inhibés au moyen d'une seule administration parentérale de l'antagoniste de récepteur de neurokinine 1 durant la période correspondante, comparée à l'administration par intraveineuse d'une solution aqueuse de l'antagoniste de récepteur de neurokinine 1 une fois par jour. En outre, l'antagoniste de récepteur de neurokinine 1 est contenu dans une quantité égale, voire inférieure à la quantité requise pour inhiber les vomissements sur une longue période par une seule administration par intraveineuse de la solution aqueuse de l'antagoniste de récepteur de neurokinine 1 une fois par jour.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001244572A AU2001244572A1 (en) | 2000-03-30 | 2001-03-28 | Microsphere preparations containing neurokinin 1 receptor antagonist |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-93540 | 2000-03-30 | ||
JP2000093540 | 2000-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001074392A1 true WO2001074392A1 (fr) | 2001-10-11 |
Family
ID=18608713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/002530 WO2001074392A1 (fr) | 2000-03-30 | 2001-03-28 | Preparations sous forme de microspheres contenant un antagoniste de recepteur de neurokinine 1 |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001244572A1 (fr) |
WO (1) | WO2001074392A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005074896A1 (fr) * | 2004-02-10 | 2005-08-18 | Takeda Pharmaceutical Company Limited | Preparation pour liberation soutenue |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5554763A (en) * | 1992-09-30 | 1996-09-10 | Sanofi | 1-azoniabicyclo[2.2.1] heptanes and pharmaceutical compositions in which they are present |
JPH10203966A (ja) * | 1996-11-21 | 1998-08-04 | Takeda Chem Ind Ltd | 徐放性マイクロカプセルおよびその製造法 |
JPH11171787A (ja) * | 1997-12-12 | 1999-06-29 | Teikoku Hormone Mfg Co Ltd | ドラスタチン10誘導体を含有するマイクロスフエア製剤 |
-
2001
- 2001-03-28 WO PCT/JP2001/002530 patent/WO2001074392A1/fr active Application Filing
- 2001-03-28 AU AU2001244572A patent/AU2001244572A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5554763A (en) * | 1992-09-30 | 1996-09-10 | Sanofi | 1-azoniabicyclo[2.2.1] heptanes and pharmaceutical compositions in which they are present |
JPH10203966A (ja) * | 1996-11-21 | 1998-08-04 | Takeda Chem Ind Ltd | 徐放性マイクロカプセルおよびその製造法 |
JPH11171787A (ja) * | 1997-12-12 | 1999-06-29 | Teikoku Hormone Mfg Co Ltd | ドラスタチン10誘導体を含有するマイクロスフエア製剤 |
Non-Patent Citations (1)
Title |
---|
J.A. RUDD ET AL.: "The action of the NK1 tachykinin receptor antagonist, CP99, 994, in antagonizing the acute and delayed emesisi induced by cisplatin in the ferret", BRITISH JOURNAL OF PHARMACOLOGY, vol. 119, 1996, pages 931 - 936, XP002942021 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005074896A1 (fr) * | 2004-02-10 | 2005-08-18 | Takeda Pharmaceutical Company Limited | Preparation pour liberation soutenue |
US7662408B2 (en) | 2004-02-10 | 2010-02-16 | Takeda Pharmaceutical Company Limited | Sustained-release preparations |
Also Published As
Publication number | Publication date |
---|---|
AU2001244572A1 (en) | 2001-10-15 |
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