WO2001073056A3 - Regulation of human oxoprolinase-like enzyme - Google Patents

Regulation of human oxoprolinase-like enzyme Download PDF

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Publication number
WO2001073056A3
WO2001073056A3 PCT/EP2001/003427 EP0103427W WO0173056A3 WO 2001073056 A3 WO2001073056 A3 WO 2001073056A3 EP 0103427 W EP0103427 W EP 0103427W WO 0173056 A3 WO0173056 A3 WO 0173056A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxoprolinase
enzyme
human
regulation
effects
Prior art date
Application number
PCT/EP2001/003427
Other languages
French (fr)
Other versions
WO2001073056A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU42518/01A priority Critical patent/AU4251801A/en
Publication of WO2001073056A2 publication Critical patent/WO2001073056A2/en
Publication of WO2001073056A3 publication Critical patent/WO2001073056A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02009—5-Oxoprolinase (ATP-hydrolysing) (3.5.2.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Human oxoprolinase-like enzyme can be regulated to enhance the effects of chemotherapy or radiation therapy of cancer cells, at the same time protecting normal cells from the toxic effects of such treatment.
PCT/EP2001/003427 2000-03-27 2001-03-27 Regulation of human oxoprolinase-like enzyme WO2001073056A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42518/01A AU4251801A (en) 2000-03-27 2001-03-27 Regulation of human oxoprolinase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19236400P 2000-03-27 2000-03-27
US60/192,364 2000-03-27

Publications (2)

Publication Number Publication Date
WO2001073056A2 WO2001073056A2 (en) 2001-10-04
WO2001073056A3 true WO2001073056A3 (en) 2002-11-07

Family

ID=22709339

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003427 WO2001073056A2 (en) 2000-03-27 2001-03-27 Regulation of human oxoprolinase-like enzyme

Country Status (2)

Country Link
AU (1) AU4251801A (en)
WO (1) WO2001073056A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020195A1 (en) * 1992-04-01 1993-10-14 Fox Chase Cancer Center Method and recombinant cells for providing increased resistance of hematopoietic progenitor cells to toxicity of chemotherapeutic agents
WO1998025945A1 (en) * 1996-12-09 1998-06-18 Cornell Research Foundation, Inc. 5-oxoprolinase
CN1313318A (en) * 2000-03-14 2001-09-19 上海市肿瘤研究所 Human protein able to suppress growth of cancer cells and its coding sequence
WO2001090366A2 (en) * 2000-05-24 2001-11-29 Curagen Corporation Human polynucleotides and polypeptides encoded thereby

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020195A1 (en) * 1992-04-01 1993-10-14 Fox Chase Cancer Center Method and recombinant cells for providing increased resistance of hematopoietic progenitor cells to toxicity of chemotherapeutic agents
WO1998025945A1 (en) * 1996-12-09 1998-06-18 Cornell Research Foundation, Inc. 5-oxoprolinase
CN1313318A (en) * 2000-03-14 2001-09-19 上海市肿瘤研究所 Human protein able to suppress growth of cancer cells and its coding sequence
WO2001090366A2 (en) * 2000-05-24 2001-11-29 Curagen Corporation Human polynucleotides and polypeptides encoded thereby

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST [online] 12 March 1999 (1999-03-12), KOEHRER K ET AL: "Homo sapiens mRNA, EST DKFZp434P1613_r1", XP002206224, retrieved from EBI, HINXTON, UK Database accession no. AL040368 *
DATABASE EM_HUM [online] 1 July 1999 (1999-07-01), WAMBUTT R ET AL: "Homo sapiens mRNA; cDNA DKFZp434H244", XP002206222, retrieved from EBI HINXTON UK Database accession no. AL096750 *
DATABASE GENESEQ [online] 9 May 2002 (2002-05-09), SHANGHAI INST OF ONCOLOGY: "Human Cancer Suppressing Protein PP1746: SeqIdNo.47.", XP002206225, retrieved from EBI, HINXTON, UK Database accession no. ABB06013 *
DATABASE PFAM [online] 1992, WATABE K ET AL: "Hydantoinase B/oxoprolinase", retrieved from EBI, HINXTON, U.K. Database accession no. P02538 *
DATABASE SWALL [online] 1 November 1999 (1999-11-01), WAMBUTT R ET AL: "Hypothetical protein", XP002206221, retrieved from EBI, HINXTON, U.K. Database accession no. Q9Y4Q0 *
DATABASE SWALL [online] 15 December 1998 (1998-12-15), DEBELLA L ET AL: "5-oxoprolinase", XP002206223, retrieved from EBI, HINXTON, UK Database accession no. O14841 *

Also Published As

Publication number Publication date
WO2001073056A2 (en) 2001-10-04
AU4251801A (en) 2001-10-08

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