WO2001070814A3 - Regulation of human rta-like g protein-coupled receptor - Google Patents

Regulation of human rta-like g protein-coupled receptor Download PDF

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Publication number
WO2001070814A3
WO2001070814A3 PCT/EP2001/003336 EP0103336W WO0170814A3 WO 2001070814 A3 WO2001070814 A3 WO 2001070814A3 EP 0103336 W EP0103336 W EP 0103336W WO 0170814 A3 WO0170814 A3 WO 0170814A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
coupled receptor
asthma
regulation
infections
Prior art date
Application number
PCT/EP2001/003336
Other languages
French (fr)
Other versions
WO2001070814A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001260147A priority Critical patent/AU2001260147A1/en
Priority to EP01933743A priority patent/EP1268548A2/en
Publication of WO2001070814A2 publication Critical patent/WO2001070814A2/en
Publication of WO2001070814A3 publication Critical patent/WO2001070814A3/en
Priority to US11/332,138 priority patent/US20060121554A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reagents which regulate human RTA-like G protein-coupled receptor treat can be used to infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
PCT/EP2001/003336 2000-03-24 2001-03-23 Regulation of human rta-like g protein-coupled receptor WO2001070814A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001260147A AU2001260147A1 (en) 2000-03-24 2001-03-23 Regulation of human rta-like g protein-coupled receptor
EP01933743A EP1268548A2 (en) 2000-03-24 2001-03-23 Regulation of human rta-like g protein-coupled receptor
US11/332,138 US20060121554A1 (en) 2000-03-24 2006-01-17 Regulation of human RTA-like GPCR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19176500P 2000-03-24 2000-03-24
US60/191,765 2000-03-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/332,138 Continuation US20060121554A1 (en) 2000-03-24 2006-01-17 Regulation of human RTA-like GPCR

Publications (2)

Publication Number Publication Date
WO2001070814A2 WO2001070814A2 (en) 2001-09-27
WO2001070814A3 true WO2001070814A3 (en) 2002-04-11

Family

ID=22706848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003336 WO2001070814A2 (en) 2000-03-24 2001-03-23 Regulation of human rta-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1268548A2 (en)
AU (1) AU2001260147A1 (en)
WO (1) WO2001070814A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064822A1 (en) * 2000-03-13 2002-05-30 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
US20030092035A1 (en) 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7510845B2 (en) 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
AU2001274112A1 (en) * 2000-06-26 2002-01-08 Bayer Aktiengesellschaft Regulation of human rta-like g protein-coupled receptor
US20030157525A1 (en) * 2001-11-26 2003-08-21 Mintier Gabriel A. Novel human G-protein coupled receptor, HGPRBMY31, and variants and methods of use thereof
WO2003082320A1 (en) * 2002-03-28 2003-10-09 Takeda Chemical Industries, Ltd. Novel screening method
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000023676A (en) * 1998-07-14 2000-01-25 Asahi Chem Ind Co Ltd Seven-pass transmembrane receptor protein erg 5
WO2000020580A1 (en) * 1998-10-08 2000-04-13 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211493A1 (en) * 2000-02-02 2003-11-13 Baughn Mariah R G-protein coupled receptors
EP1261710A2 (en) * 2000-03-08 2002-12-04 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000023676A (en) * 1998-07-14 2000-01-25 Asahi Chem Ind Co Ltd Seven-pass transmembrane receptor protein erg 5
WO2000020580A1 (en) * 1998-10-08 2000-04-13 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
EP1122313A1 (en) * 1998-10-08 2001-08-08 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 3 December 1999 (1999-12-03), HATTORI M. ET AL.: "Homo sapiens genomic DNA, chromosome 11q13, clone:RP11-757G1, WORKING DRAFT SEQUENCE, 24 unordered pieces", XP002184754 *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 04 31 August 2000 (2000-08-31) *
See also references of EP1268548A2 *

Also Published As

Publication number Publication date
AU2001260147A1 (en) 2001-10-03
EP1268548A2 (en) 2003-01-02
WO2001070814A2 (en) 2001-09-27

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