WO2001069648A3 - Time of flight mass spectrometry apparatus - Google Patents

Time of flight mass spectrometry apparatus Download PDF

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Publication number
WO2001069648A3
WO2001069648A3 PCT/GB2001/001101 GB0101101W WO0169648A3 WO 2001069648 A3 WO2001069648 A3 WO 2001069648A3 GB 0101101 W GB0101101 W GB 0101101W WO 0169648 A3 WO0169648 A3 WO 0169648A3
Authority
WO
WIPO (PCT)
Prior art keywords
time
ion mirror
flight
flight means
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/001101
Other languages
French (fr)
Other versions
WO2001069648A2 (en
Inventor
Alexander William Colburn
Peter John Derrick
Anastassios Giannakopulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Warwick filed Critical University of Warwick
Priority to EP01911896A priority Critical patent/EP1264331A2/en
Priority to US10/221,378 priority patent/US6781122B2/en
Priority to AU40818/01A priority patent/AU4081801A/en
Publication of WO2001069648A2 publication Critical patent/WO2001069648A2/en
Publication of WO2001069648A3 publication Critical patent/WO2001069648A3/en
Anticipated expiration legal-status Critical
Priority to US10/925,192 priority patent/US7075065B2/en
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Mass spectrometry apparatus (105) comprises a serial arrangement of an ion source (110), first time of flight means, a field free region (120), means to fragment the molecules, a second time of flight means and a large area detector (160). The second time of flight means includes an ion mirror (150), the ion mirror (150) being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror (150). The means provided to fragment the ions from the first time of flight means can be a collision cell (140) or in the field free region (220) or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror (150), and the detecting surface of the detector (160) is mounted in the time focal surface of the ion mirror (150).
PCT/GB2001/001101 2000-03-13 2001-03-13 Time of flight mass spectrometry apparatus Ceased WO2001069648A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01911896A EP1264331A2 (en) 2000-03-13 2001-03-13 Time of flight mass spectrometry apparatus
US10/221,378 US6781122B2 (en) 2000-03-13 2001-03-13 Time of flight mass spectrometry apparatus
AU40818/01A AU4081801A (en) 2000-03-13 2001-03-13 Time of flight mass spectrometry apparatus
US10/925,192 US7075065B2 (en) 2000-03-13 2004-08-24 Time of flight mass spectrometry apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0006046.7 2000-03-13
GBGB0006046.7A GB0006046D0 (en) 2000-03-13 2000-03-13 Time of flight mass spectrometry apparatus

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10221378 A-371-Of-International 2001-03-13
US10/925,192 Continuation US7075065B2 (en) 2000-03-13 2004-08-24 Time of flight mass spectrometry apparatus

Publications (2)

Publication Number Publication Date
WO2001069648A2 WO2001069648A2 (en) 2001-09-20
WO2001069648A3 true WO2001069648A3 (en) 2001-12-20

Family

ID=9887538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001101 Ceased WO2001069648A2 (en) 2000-03-13 2001-03-13 Time of flight mass spectrometry apparatus

Country Status (5)

Country Link
US (2) US6781122B2 (en)
EP (1) EP1264331A2 (en)
AU (1) AU4081801A (en)
GB (1) GB0006046D0 (en)
WO (1) WO2001069648A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0006046D0 (en) * 2000-03-13 2000-05-03 Univ Warwick Time of flight mass spectrometry apparatus
US20090026122A1 (en) 2002-03-11 2009-01-29 Janusz Biocompatible solid-phase microextraction coatings and methods for their preparation
US8598325B2 (en) 2002-03-11 2013-12-03 Janusz B. Pawliszyn Solid-phase microextraction coatings and methods for their preparation
US7259019B2 (en) 2002-03-11 2007-08-21 Pawliszyn Janusz B Multiple sampling device and method for investigating biological systems
US9870907B2 (en) 2002-03-11 2018-01-16 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US9733234B2 (en) 2002-03-11 2017-08-15 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US7232689B2 (en) * 2002-03-11 2007-06-19 Pawliszyn Janusz B Calibration procedure for investigating biological systems
WO2017193213A1 (en) 2016-05-10 2017-11-16 Jp Scientific Limited System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device
DE60325180D1 (en) * 2002-03-11 2009-01-22 Janusz B Pawliszyn MICRO-DEVICES FOR THE STUDY OF BIOLOGICAL SYSTEMS
US7095018B2 (en) * 2004-12-29 2006-08-22 Wisconsin Alumni Research Foundation Deposition of samples and sample matrix for enhancing the sensitivity of matrix assisted laser desorption/ionization mass spectrometry
US7351958B2 (en) * 2005-01-24 2008-04-01 Applera Corporation Ion optics systems
CA2609802A1 (en) * 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
GB2462065B (en) * 2008-07-17 2013-03-27 Kratos Analytical Ltd TOF mass spectrometer for stigmatic imaging and associated method
GB2454962B (en) * 2008-07-25 2009-10-28 Kratos Analytical Ltd Method and apparatus for ion axial spatial distribution focusing
WO2012033094A1 (en) * 2010-09-08 2012-03-15 株式会社島津製作所 Time-of-flight mass spectrometer
CN105518447B (en) * 2013-09-09 2018-01-16 株式会社岛津制作所 The fragments of peptides preparation kit and analysis method used in the preparation method and this method of fragments of peptides
CN105304453B (en) * 2015-11-10 2017-04-12 中国科学院化学研究所 Vacuum external regulation apparatus for pitch angle of high-resolution flying time mass spectrum detector
JP6930978B2 (en) 2016-03-02 2021-09-01 ジェイ・ピィ・サイエンティフィック・リミテッドＪｐ Ｓｃｉｅｎｔｉｆｉｃ Ｌｉｍｉｔｅｄ Solid-phase microextraction coating

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033279A1 (en) * 1994-05-31 1995-12-07 University Of Warwick Tandem mass spectrometry apparatus
US5645545A (en) * 1995-08-14 1997-07-08 Zimmer, Inc. Self reaming intramedullary nail and method for using the same
WO1998007177A1 (en) * 1996-08-09 1998-02-19 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US5869829A (en) * 1996-07-03 1999-02-09 Analytica Of Branford, Inc. Time-of-flight mass spectrometer with first and second order longitudinal focusing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818862A (en) * 1987-10-21 1989-04-04 Iowa State University Research Foundation, Inc. Characterization of compounds by time-of-flight measurement utilizing random fast ions
US5464985A (en) * 1993-10-01 1995-11-07 The Johns Hopkins University Non-linear field reflectron
US5814813A (en) * 1996-07-08 1998-09-29 The Johns Hopkins University End cap reflection for a time-of-flight mass spectrometer and method of using the same
JP2002502086A (en) * 1998-01-23 2002-01-22 アナリティカ オブ ブランフォード インコーポレーテッド Mass spectrometry from the surface
US6348688B1 (en) 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
ATE460744T1 (en) * 1998-09-25 2010-03-15 Oregon State TANDEM FLIGHT TIME MASS SPECTROMETER
US6674069B1 (en) * 1998-12-17 2004-01-06 Jeol Usa, Inc. In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation
GB0006046D0 (en) * 2000-03-13 2000-05-03 Univ Warwick Time of flight mass spectrometry apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033279A1 (en) * 1994-05-31 1995-12-07 University Of Warwick Tandem mass spectrometry apparatus
US5645545A (en) * 1995-08-14 1997-07-08 Zimmer, Inc. Self reaming intramedullary nail and method for using the same
US5869829A (en) * 1996-07-03 1999-02-09 Analytica Of Branford, Inc. Time-of-flight mass spectrometer with first and second order longitudinal focusing
WO1998007177A1 (en) * 1996-08-09 1998-02-19 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN Y H ET AL: "Orthogonal electron impact source for a time-of-flight mass spectrometer with high mass resolving power1", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 185-187, 29 April 1999 (1999-04-29), pages 221 - 226, XP004163672, ISSN: 1387-3806 *
FRANZEN J ET AL: "Recent progress in matrix-assisted laser desorption ionization postsource decay", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 206, no. 3, 22 March 2001 (2001-03-22), pages 275 - 286, XP004233335, ISSN: 1387-3806 *
See also references of EP1264331A2 *

Also Published As

Publication number Publication date
WO2001069648A2 (en) 2001-09-20
US7075065B2 (en) 2006-07-11
US6781122B2 (en) 2004-08-24
GB0006046D0 (en) 2000-05-03
AU4081801A (en) 2001-09-24
US20050023459A1 (en) 2005-02-03
EP1264331A2 (en) 2002-12-11
US20030183758A1 (en) 2003-10-02

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