WO2001068814A3 - Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations - Google Patents

Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations Download PDF

Info

Publication number
WO2001068814A3
WO2001068814A3 PCT/US2001/007674 US0107674W WO0168814A3 WO 2001068814 A3 WO2001068814 A3 WO 2001068814A3 US 0107674 W US0107674 W US 0107674W WO 0168814 A3 WO0168814 A3 WO 0168814A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
populations
cellular
cardiomyocyte
cell
Prior art date
Application number
PCT/US2001/007674
Other languages
English (en)
Other versions
WO2001068814A2 (fr
Inventor
Loren J Field
Original Assignee
Advanced Res & Tech Inst
Loren J Field
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, Loren J Field filed Critical Advanced Res & Tech Inst
Priority to CA002402245A priority Critical patent/CA2402245A1/fr
Priority to AU2001243551A priority patent/AU2001243551A1/en
Priority to US10/220,205 priority patent/US20030211088A1/en
Priority to IL15160501A priority patent/IL151605A0/xx
Priority to EP01916536A priority patent/EP1265987A2/fr
Priority to JP2001567298A priority patent/JP2004504807A/ja
Publication of WO2001068814A2 publication Critical patent/WO2001068814A2/fr
Publication of WO2001068814A3 publication Critical patent/WO2001068814A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne des populations cellulaires enrichies en cardiomyocytes de conduction, ainsi que des procédés et des matériaux nécessaires à leur obtention. Ces populations peuvent être utilisées pour faire prendre une greffe de tissu myocardique mammalien, par exemple dans la mise en place de stimulateur cardiaque biologique. L'invention concerne aussi des greffes myocardiques cellulaires restauratrices destinées à améliorer la fonction contractile de segments du myocarde endommagés, ainsi que des articles conçus pour être implantés dans le coeur (par exemple des électrodes de stimulateur cardiaque), recouverts de cardiomyocytes viables et comprenant, éventuellement, un support pour les cardiomyocytes.
PCT/US2001/007674 2000-03-10 2001-03-12 Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations WO2001068814A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002402245A CA2402245A1 (fr) 2000-03-10 2001-03-12 Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations
AU2001243551A AU2001243551A1 (en) 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
US10/220,205 US20030211088A1 (en) 2001-03-12 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
IL15160501A IL151605A0 (en) 2000-03-10 2001-03-12 Cardiomyocyte cell populations, methods for obtaining the same and devices utilizing the same
EP01916536A EP1265987A2 (fr) 2000-03-10 2001-03-12 Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations
JP2001567298A JP2004504807A (ja) 2000-03-10 2001-03-12 多分化能細胞および心筋細胞集団、並びに該集団への経路およびその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18850700P 2000-03-10 2000-03-10
US60/188,507 2000-03-10

Publications (2)

Publication Number Publication Date
WO2001068814A2 WO2001068814A2 (fr) 2001-09-20
WO2001068814A3 true WO2001068814A3 (fr) 2002-05-30

Family

ID=22693441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007674 WO2001068814A2 (fr) 2000-03-10 2001-03-12 Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations

Country Status (6)

Country Link
EP (1) EP1265987A2 (fr)
JP (1) JP2004504807A (fr)
AU (1) AU2001243551A1 (fr)
CA (1) CA2402245A1 (fr)
IL (1) IL151605A0 (fr)
WO (1) WO2001068814A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
EP1412479A4 (fr) 2001-07-12 2004-07-28 Geron Corp Cellules de la lignee des cardiomyocytes produites a partir de cellules souches humaines pluripotentielles
WO2003039344A2 (fr) 2001-11-08 2003-05-15 The Regents Of The University Of California Methodes et compositions de correction des troubles de la conduction cardiaque
EP1606396A2 (fr) 2003-03-21 2005-12-21 Gabriella Minchiotti Methode favorisant la differenciation de cellules staminales
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
ES2770067T3 (es) 2004-05-11 2020-06-30 Ncardia Ag Descubrimiento de fármacos basado en células diferenciadas in vitro
WO2006021459A1 (fr) * 2004-08-27 2006-03-02 Cell Center Cologne Gmbh Compositions et methodes destinees a la modulation de la differenciation cellulaire
GB2441718B (en) 2005-06-22 2010-10-06 Geron Corp Differentiation of human embryonic stem cells to cardiomyocyte-lineage cells
CN100422739C (zh) * 2006-04-13 2008-10-01 东南大学 便携式缺氧操作箱
US20110027234A1 (en) * 2007-04-11 2011-02-03 Technion Research & Development Foundation Ltd. Methods for identification and selection of human embryonic stem cell derived cells
CN105400735A (zh) 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
WO2012098260A1 (fr) 2011-01-21 2012-07-26 Axiogenesis Ag Système non viral pour générer des cellules souches pluripotentes induites (ips)
US9592398B2 (en) 2011-05-12 2017-03-14 Medtronic, Inc. Leadless implantable medical device with osmotic pump
WO2017192602A1 (fr) 2016-05-02 2017-11-09 Emory University Utilisations d'inhibiteurs de la transition épithélio-mésenchymateuse dans la génération de cellules pacemaker

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5103821A (en) * 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
WO1995014079A1 (fr) * 1993-11-16 1995-05-26 Indiana University Foundation Greffes myocardiques et compositions cellulaires utiles pour lesdites greffes
US6127176A (en) * 1998-06-10 2000-10-03 Cleveland Clinic Foundation Mutant cell lines unresponsive to interleukin 1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5103821A (en) * 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
WO1995014079A1 (fr) * 1993-11-16 1995-05-26 Indiana University Foundation Greffes myocardiques et compositions cellulaires utiles pour lesdites greffes
US6127176A (en) * 1998-06-10 2000-10-03 Cleveland Clinic Foundation Mutant cell lines unresponsive to interleukin 1

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
GOURDIE R G ET AL: "THE SPATIAL DISTRIBUTION AND RELATIVE ABUNDANCE OF GAP-JUNCTIONAL CONNEXIN40 AND CONNEXIN43 CORRELATE TO FUNCTIONAL PROPERTIES OF COMPONENTS OF THE CARDIAC ATRIOVENTRICULAR CONDUCTION SYSTEM", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 105, 1993, pages 985 - 991, XP000905088 *
GOURDIE ROBERT G ET AL: "Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 12, 9 June 1998 (1998-06-09), June 9, 1998, pages 6815 - 6818, XP002179468, ISSN: 0027-8424 *
KUPERSHMIDT SABINA ET AL: "Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.", CIRCULATION RESEARCH, vol. 84, no. 2, 5 February 1999 (1999-02-05), pages 146 - 152, XP002179467, ISSN: 0009-7330 *
MALTSEV V A ET AL: "CARDIOMYOCYTES DIFFERENTIATED IN VITRO FROM EMBRYONIC STEM CELLS DEVELOPMENTALLY EXPRESS CARDIA-SPECIFIC GENES AND IONIC CURRENTS", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 75, no. 2, 1 August 1994 (1994-08-01), pages 233 - 244, XP000673463, ISSN: 0009-7330 *
MALTSEV VICTOR A ET AL: "Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinus nodal, atrial and ventricular cell types.", MECHANISMS OF DEVELOPMENT, vol. 44, no. 1, 1993, pages 41 - 50, XP000671041, ISSN: 0925-4773 *
OOSTHOEK PETRA W ET AL: "Immunohistochemical delineation of the conduction system: I. The sinoatrial node.", CIRCULATION RESEARCH, vol. 73, no. 3, 1993, pages 473 - 481, XP001028240, ISSN: 0009-7330 *
OOSTHOEK PETRA W ET AL: "Immunohistochemical delineation of the conduction system: II. The atrioventricular node and Purkinje fibers.", CIRCULATION RESEARCH, vol. 73, no. 3, 1993, pages 482 - 491, XP001028241, ISSN: 0009-7330 *
OYAMADA YUMIKO ET AL: "Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro.", EXPERIMENTAL CELL RESEARCH, vol. 229, no. 2, 1996, pages 318 - 326, XP002179469, ISSN: 0014-4827 *
WOBUS ANNA M ET AL: "Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 29, no. 6, 1997, pages 1525 - 1539, XP002179466, ISSN: 0022-2828 *

Also Published As

Publication number Publication date
JP2004504807A (ja) 2004-02-19
EP1265987A2 (fr) 2002-12-18
WO2001068814A2 (fr) 2001-09-20
IL151605A0 (en) 2003-04-10
AU2001243551A1 (en) 2001-09-24
CA2402245A1 (fr) 2001-09-20

Similar Documents

Publication Publication Date Title
WO2001068814A3 (fr) Populations de cellules pluripotentes et de cardiomyocytes, moyens d'obtention et utilisations
US6190893B1 (en) Electroactive materials for stimulation of biological activity of bone marrow stromal cells
Noff et al. Basic fibroblast growth factor enhances the capacity of bone marrow cells to form bone‐like nodules in vitro
ATE382681T1 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
ATE288932T1 (de) Neue biomaterialien
EP1690546A3 (fr) Greffons pour cicatrices myocardiques, méthodes et préparations cellulaires associées
EP2278022A3 (fr) Vecteurs d'expression, systèmes de transfection et procédé d'utilisation correspondant
WO2004011603A3 (fr) Cardiomyocytes fonctionnels provenant de cellules souches embryonnaires humaines
EP1077254A3 (fr) Potentialités de différenciation en multiples lignées cellulaires mésodermiques pour des cellules de stroma dérivées de tissu adipeux et leurs applications
WO2001007568A3 (fr) Cellules musculaires et leur utilisation dans la reparation cardiaque
WO2004080533A8 (fr) Appareil et procede d'application de signaux electriques pour modifier l'expression genique dans le tissu cardiaque
WO2003004605A3 (fr) Osteoblastes et cellules mesenchymateuses provenant de cellule souche embryonnaire humaine
EP1686172A3 (fr) Greffes myocardiques et compositions cellulaires utiles pour lesdites greffes
ZA975851B (en) Hepatocyte grown factor receptor agonists and uses thereof
EP2771454B1 (fr) Procédé de dérivation des mélanocytes provenant de la gaine de racine extérieure du follicule pileux et la préparation pour greffe
PL337019A1 (en) Peptide-coated implants and method of obtaining them
DE602004004541D1 (en) Myokard-stimulation
AU8180001A (en) Human growth hormone to stimulate mobilization of pluripotent hematopoietic stemcells
FR2662698B1 (fr)
EP1135531A4 (fr) Methodes d'introduction de cellules heterologues chez les poissons
WO2001019379A3 (fr) Methodes de traitement des dystrophies musculaires
HK1048498A1 (zh) 自然殺傷細胞的增殖方法
WO2000029551A3 (fr) Cellules, procedes de culture et leurs utilisations
WO2000066732A3 (fr) Laminine 8 et ses procedes d'utilisation
WO2001022978A3 (fr) Transplantation de cellules souches (msc) de moelle osseuse autologues en vue de la regeneration myocardique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2002/1129/KOL

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 151605

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2402245

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2001 567298

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2001243551

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001916536

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001916536

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10220205

Country of ref document: US

WWW Wipo information: withdrawn in national office

Ref document number: 2001916536

Country of ref document: EP