WO2001066567A3 - Design, synthesis and use of affinity ligands - Google Patents

Design, synthesis and use of affinity ligands Download PDF

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Publication number
WO2001066567A3
WO2001066567A3 PCT/GB2001/001011 GB0101011W WO0166567A3 WO 2001066567 A3 WO2001066567 A3 WO 2001066567A3 GB 0101011 W GB0101011 W GB 0101011W WO 0166567 A3 WO0166567 A3 WO 0166567A3
Authority
WO
WIPO (PCT)
Prior art keywords
target
region
domain
synthesis
design
Prior art date
Application number
PCT/GB2001/001011
Other languages
French (fr)
Other versions
WO2001066567A2 (en
Inventor
Beining Chen
Richard Michael Day
Khalku Karim
Anthony Peter Francis Turner
Original Assignee
Univ Cranfield
Beining Chen
Richard Michael Day
Khalku Karim
Anthony Peter Francis Turner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cranfield, Beining Chen, Richard Michael Day, Khalku Karim, Anthony Peter Francis Turner filed Critical Univ Cranfield
Priority to AU2001240783A priority Critical patent/AU2001240783A1/en
Priority to GB0223228A priority patent/GB2376948B/en
Publication of WO2001066567A2 publication Critical patent/WO2001066567A2/en
Publication of WO2001066567A3 publication Critical patent/WO2001066567A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

An affinity ligand is constructed from at least 3 domains: (1) a recognition domain, e.g. a 3-6 amino acid chain specific for a peptide region of a target; this may be discovered and/or optimised by fitting candidate structures or parts thereof to a model of the target in a computer memory; (2) an affinity domain, e.g. a domain capable of binding to a particular type of region of the target such as a glycosylation region; and (3) a flexible linker having a functional group enabling the ligand to be immobilised to a sensor surface to create a specific biosensor.
PCT/GB2001/001011 2000-03-08 2001-03-08 Design, synthesis and use of affinity ligands WO2001066567A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001240783A AU2001240783A1 (en) 2000-03-08 2001-03-08 Design, synthesis and use of affinity ligands
GB0223228A GB2376948B (en) 2000-03-08 2001-03-08 Design synthesis and use of affinity ligands

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0005469.2 2000-03-08
GBGB0005469.2A GB0005469D0 (en) 2000-03-08 2000-03-08 A novel building block approach for designing affinity ligands for glycosylated haemoglobin HbA1c

Publications (2)

Publication Number Publication Date
WO2001066567A2 WO2001066567A2 (en) 2001-09-13
WO2001066567A3 true WO2001066567A3 (en) 2001-12-20

Family

ID=9887130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001011 WO2001066567A2 (en) 2000-03-08 2001-03-08 Design, synthesis and use of affinity ligands

Country Status (3)

Country Link
AU (1) AU2001240783A1 (en)
GB (2) GB0005469D0 (en)
WO (1) WO2001066567A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399645B2 (en) * 2004-05-12 2008-07-15 Applera Corporation Constrained cis-diol-borate bioconjugation system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (en) * 1997-10-21 1999-04-29 Cranfield University Affinity ligands, their production and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (en) * 1997-10-21 1999-04-29 Cranfield University Affinity ligands, their production and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEVAN P ET AL: "Identifying small-molecule lead compounds: the screening approach to drug discovery", TRENDS IN BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 3, March 1995 (1995-03-01), pages 115 - 121, XP004207136, ISSN: 0167-7799 *
CHEN B ET AL: "The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin.", BIOSENSORS & BIOELECTRONICS, vol. 13, no. 7-8, 1 October 1998 (1998-10-01), pages 779 - 785, XP002097484, ISSN: 0956-5663 *
LEWIS R A: "RATIONAL METHODS FOR SITE-DIRECTED DRUG DESIGN NOVEL APPROACHES FOR THE DISCOVERY OF POTENTIAL LIGANDS", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 19, no. 4, 1991, pages 883 - 887, XP001013464, ISSN: 0300-5127 *

Also Published As

Publication number Publication date
AU2001240783A1 (en) 2001-09-17
GB2376948B (en) 2004-09-29
GB2376948A (en) 2002-12-31
GB0223228D0 (en) 2002-11-13
GB0005469D0 (en) 2000-04-26
WO2001066567A2 (en) 2001-09-13

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