WO2001064888A3 - Kunitz domain polypeptide zkun8 - Google Patents

Kunitz domain polypeptide zkun8 Download PDF

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Publication number
WO2001064888A3
WO2001064888A3 PCT/US2001/006295 US0106295W WO0164888A3 WO 2001064888 A3 WO2001064888 A3 WO 2001064888A3 US 0106295 W US0106295 W US 0106295W WO 0164888 A3 WO0164888 A3 WO 0164888A3
Authority
WO
WIPO (PCT)
Prior art keywords
kunitz domain
zkun8
proteinase inhibitors
domain polypeptide
seq
Prior art date
Application number
PCT/US2001/006295
Other languages
French (fr)
Other versions
WO2001064888A2 (en
Inventor
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU2001241817A priority Critical patent/AU2001241817A1/en
Publication of WO2001064888A2 publication Critical patent/WO2001064888A2/en
Publication of WO2001064888A3 publication Critical patent/WO2001064888A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:7, wherein the sequence is at least 90 % identical to residues 328 through 378 or 386 through 436 of SEQ ID NO:2. Also disclosed are methods for producing the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
PCT/US2001/006295 2000-02-29 2001-02-27 Kunitz domain polypeptide zkun8 WO2001064888A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001241817A AU2001241817A1 (en) 2000-02-29 2001-02-27 Kunitz domain polypeptide zkun8

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51522500A 2000-02-29 2000-02-29
US09/515,225 2000-02-29

Publications (2)

Publication Number Publication Date
WO2001064888A2 WO2001064888A2 (en) 2001-09-07
WO2001064888A3 true WO2001064888A3 (en) 2002-02-28

Family

ID=24050458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006295 WO2001064888A2 (en) 2000-02-29 2001-02-27 Kunitz domain polypeptide zkun8

Country Status (2)

Country Link
AU (1) AU2001241817A1 (en)
WO (1) WO2001064888A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
BR0307907A2 (en) * 2002-02-21 2011-07-05 Wyeth Corp gasp1: protein containing folistatin domain
JP4429728B2 (en) 2002-02-21 2010-03-10 ワイス エルエルシー Follistatin domain-containing protein
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US7785587B2 (en) 2003-06-02 2010-08-31 Wyeth Therapeutic methods for muscular or neuromuscular disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061615A1 (en) * 1998-05-28 1999-12-02 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061615A1 (en) * 1998-05-28 1999-12-02 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 14 July 1999 (1999-07-14), HILLIER L ET AL: "WashU-NCI human EST project", XP002179601 *
DATABASE EMBL 18 April 1997 (1997-04-18), ADAMS M D ET AL: "Initial assessment of human gene diversity and expression patterns based upon 83 million basepairs of cDNA sequence", XP002179600 *
NATURE, vol. 377, 1995, pages 3 - 174 *

Also Published As

Publication number Publication date
WO2001064888A2 (en) 2001-09-07
AU2001241817A1 (en) 2001-09-12

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