WO2001064345A3 - Microvolume liquid dispensing - Google Patents

Microvolume liquid dispensing Download PDF

Info

Publication number
WO2001064345A3
WO2001064345A3 PCT/US2001/006174 US0106174W WO0164345A3 WO 2001064345 A3 WO2001064345 A3 WO 2001064345A3 US 0106174 W US0106174 W US 0106174W WO 0164345 A3 WO0164345 A3 WO 0164345A3
Authority
WO
WIPO (PCT)
Prior art keywords
tube
reservoir
piston
tap
metering
Prior art date
Application number
PCT/US2001/006174
Other languages
French (fr)
Other versions
WO2001064345A2 (en
Inventor
Jeffrey A Karg
Douglas W Kroncke
Michael J Jobin
Original Assignee
Boston Innovation Inc
Jeffrey A Karg
Douglas W Kroncke
Michael J Jobin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/591,807 external-priority patent/US6706538B1/en
Priority claimed from US09/591,803 external-priority patent/US6620383B1/en
Application filed by Boston Innovation Inc, Jeffrey A Karg, Douglas W Kroncke, Michael J Jobin filed Critical Boston Innovation Inc
Priority to AU2001241780A priority Critical patent/AU2001241780A1/en
Priority to EP01913075A priority patent/EP1261430A2/en
Publication of WO2001064345A2 publication Critical patent/WO2001064345A2/en
Publication of WO2001064345A3 publication Critical patent/WO2001064345A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A sealed reservoir (21) for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids includes an integrated metering tap. The tap has a metering tube (25), which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube (25) includes a tube end closure (31) in a lower portion of the tube, a port (32) above the tube end closure, and a piston (29) in an upper portion of the tube. The piston (29) is movable between a down position that seals the side port (32) and an up position above the port (32). Movement of the piston (29) from the up position to the down position can displace from 10 nanoliters to 20 microliters. Several such dispensers are arranged in an integrated array of reservoir/tap units (20) suitable for use in automated, multi-well formats such as those commonly used for high-throughput screening.
PCT/US2001/006174 2000-02-29 2001-02-27 Microvolume liquid dispensing WO2001064345A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001241780A AU2001241780A1 (en) 2000-02-29 2001-02-27 Microvolume liquid dispensing
EP01913075A EP1261430A2 (en) 2000-02-29 2001-02-27 Microvolume liquid dispensing

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US18581000P 2000-02-29 2000-02-29
US60/185,810 2000-02-29
US09/591,807 US6706538B1 (en) 2000-02-29 2000-06-12 Microvolume liquid dispensing array
US09/591,807 2000-06-12
US09/591,803 2000-06-12
US09/591,803 US6620383B1 (en) 2000-02-29 2000-06-12 Microvolume liquid dispensing device

Publications (2)

Publication Number Publication Date
WO2001064345A2 WO2001064345A2 (en) 2001-09-07
WO2001064345A3 true WO2001064345A3 (en) 2002-01-31

Family

ID=27392021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006174 WO2001064345A2 (en) 2000-02-29 2001-02-27 Microvolume liquid dispensing

Country Status (3)

Country Link
EP (1) EP1261430A2 (en)
AU (1) AU2001241780A1 (en)
WO (1) WO2001064345A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002324687A1 (en) * 2001-08-13 2003-03-03 Boston Innovation Inc. Microfluidic mixing and dispensing
US7459128B2 (en) 2002-08-13 2008-12-02 Molecular Bioproducts, Inc. Microfluidic mixing and dispensing
US7592185B2 (en) 2004-02-17 2009-09-22 Molecular Bioproducts, Inc. Metering doses of sample liquids

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4844868A (en) * 1985-06-18 1989-07-04 Kabushiki Kaisha Toshiba Automatic chemical analysis reagent distribution and analysis apparatus
WO1990008075A1 (en) * 1989-01-12 1990-07-26 Microvol Limited Pressurised metering dispenser
US5226462A (en) * 1991-07-26 1993-07-13 Carl Richard A Introducing measured amounts of liquid into receptacles
WO1999015876A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
WO2000024511A1 (en) * 1998-10-26 2000-05-04 The Regents Of The University Of California An integrated titer plate-injector head for microdrop array preparation, storage and transfer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4844868A (en) * 1985-06-18 1989-07-04 Kabushiki Kaisha Toshiba Automatic chemical analysis reagent distribution and analysis apparatus
WO1990008075A1 (en) * 1989-01-12 1990-07-26 Microvol Limited Pressurised metering dispenser
US5226462A (en) * 1991-07-26 1993-07-13 Carl Richard A Introducing measured amounts of liquid into receptacles
WO1999015876A1 (en) * 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
WO2000024511A1 (en) * 1998-10-26 2000-05-04 The Regents Of The University Of California An integrated titer plate-injector head for microdrop array preparation, storage and transfer

Also Published As

Publication number Publication date
EP1261430A2 (en) 2002-12-04
AU2001241780A1 (en) 2001-09-12
WO2001064345A2 (en) 2001-09-07

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