WO2001062981A1 - Plate-forme destinee a la decouverte de genes bacteriens impliques dans la modification d'arn - Google Patents
Plate-forme destinee a la decouverte de genes bacteriens impliques dans la modification d'arn Download PDFInfo
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- WO2001062981A1 WO2001062981A1 PCT/US2001/005920 US0105920W WO0162981A1 WO 2001062981 A1 WO2001062981 A1 WO 2001062981A1 US 0105920 W US0105920 W US 0105920W WO 0162981 A1 WO0162981 A1 WO 0162981A1
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- rna
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- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005758 transcription activity Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- RVCNQQGZJWVLIP-VPCXQMTMSA-N uridin-5-yloxyacetic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(OCC(O)=O)=C1 RVCNQQGZJWVLIP-VPCXQMTMSA-N 0.000 description 1
- YIZYCHKPHCPKHZ-UHFFFAOYSA-N uridine-5-acetic acid methyl ester Natural products COC(=O)Cc1cn(C2OC(CO)C(O)C2O)c(=O)[nH]c1=O YIZYCHKPHCPKHZ-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
- QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
- JCZSFCLRSONYLH-QYVSTXNMSA-N wyosin Chemical compound N=1C(C)=CN(C(C=2N=C3)=O)C=1N(C)C=2N3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JCZSFCLRSONYLH-QYVSTXNMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne des procédés d'identification de gènes et des produits de gènes impliqués dans la modification d'ARN (comme montré Figure 2), ainsi que des méthodes destinées au criblage d'activité de composés test ou d'antibiotiques. Elle concerne, en outre, les produits de gènes identifiés dans les méthodes, les gènes qui codent pour ces produits, des molécules sentinelles modifiées produites par ces produits, ainsi que des composés ou des antibiotiques qui permettent d'inhiber le processus de modification.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01914470A EP1263986A4 (fr) | 2000-02-25 | 2001-02-23 | Plate-forme destinee a la decouverte de genes bacteriens impliques dans la modification d'arn |
| CA002401018A CA2401018A1 (fr) | 2000-02-25 | 2001-02-23 | Plate-forme destinee a la decouverte de genes bacteriens impliques dans la modification d'arn |
| AU2001239856A AU2001239856A1 (en) | 2000-02-25 | 2001-02-23 | Platform for the discovery of the bacterial genes involved in rna modification |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18500000P | 2000-02-25 | 2000-02-25 | |
| US18507100P | 2000-02-25 | 2000-02-25 | |
| US60/185,000 | 2000-02-25 | ||
| US60/185,071 | 2000-02-25 | ||
| US60/255,506 | 2000-02-25 | ||
| US22550500P | 2000-08-15 | 2000-08-15 | |
| US22550600P | 2000-08-15 | 2000-08-15 | |
| US60/225,505 | 2000-08-15 | ||
| US25550600P | 2000-12-13 | 2000-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001062981A1 true WO2001062981A1 (fr) | 2001-08-30 |
Family
ID=34069426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2001/005920 WO2001062981A1 (fr) | 2000-02-25 | 2001-02-23 | Plate-forme destinee a la decouverte de genes bacteriens impliques dans la modification d'arn |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP1261734A1 (fr) |
| AU (1) | AU2001239856A1 (fr) |
| WO (1) | WO2001062981A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013033019A1 (fr) * | 2011-08-31 | 2013-03-07 | University Of Utah Research Foundation | Procédés de détermination de l'intégrité d'un échantillon biologique |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108251517A (zh) * | 2017-12-29 | 2018-07-06 | 武汉艾德士生物科技有限公司 | 一种分析体系内相似序列相对数量的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834184A (en) * | 1995-05-17 | 1998-11-10 | Harada; Kazuo | In vivo selection of RNA-binding peptides |
| US5989814A (en) * | 1997-04-01 | 1999-11-23 | Reagents Of The University Of California | Screening methods in eucaryotic cells |
| US6008034A (en) * | 1996-04-15 | 1999-12-28 | Givaudan-Roure (International) Sa | Hydroperoxide lyases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9106486A (pt) * | 1990-05-23 | 1993-05-25 | Isis Pharmaceuticals Inc | Composicao para modulacao da atividade de um rna e processo para tratamento de um organismo que tem uma doenca que se caracteriza para producao indesejada de uma proteina |
| US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5593835A (en) * | 1995-05-12 | 1997-01-14 | President And Fellows Of Harvard College | Methods and kits for RNA binding compounds |
| EP0791008A4 (fr) * | 1995-09-08 | 2003-04-23 | Anadys Pharmaceuticals Inc | Recherche par criblage de composes presentant une affinite avec l'arn |
| US5871987A (en) * | 1996-11-01 | 1999-02-16 | Cubist Pharmaceuticals, Inc. | Candida tyrosyl-tRNA synthetase proteins, nucleic acids and strains comprising same |
| FR2762014B1 (fr) * | 1997-04-10 | 1999-06-04 | Itzik Harosh | Utilisation d'apobeg1 ou des proteines associees, ou des genes responsables de la maladie d'andersons comme cible de traitement de l'atherosclerose et de l'obesite et techniques associees de clonage et de criblage d'inhibiteurs |
| WO2001079543A2 (fr) * | 2000-04-19 | 2001-10-25 | Ribotargets Limited | Analyse d'identification d'un compose d'essai |
-
2001
- 2001-02-23 WO PCT/US2001/005920 patent/WO2001062981A1/fr not_active Application Discontinuation
- 2001-02-23 EP EP01918229A patent/EP1261734A1/fr not_active Withdrawn
- 2001-02-23 EP EP01914470A patent/EP1263986A4/fr not_active Withdrawn
- 2001-02-23 AU AU2001239856A patent/AU2001239856A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834184A (en) * | 1995-05-17 | 1998-11-10 | Harada; Kazuo | In vivo selection of RNA-binding peptides |
| US6008034A (en) * | 1996-04-15 | 1999-12-28 | Givaudan-Roure (International) Sa | Hydroperoxide lyases |
| US5989814A (en) * | 1997-04-01 | 1999-11-23 | Reagents Of The University Of California | Screening methods in eucaryotic cells |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP1263986A4 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013033019A1 (fr) * | 2011-08-31 | 2013-03-07 | University Of Utah Research Foundation | Procédés de détermination de l'intégrité d'un échantillon biologique |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1261734A1 (fr) | 2002-12-04 |
| AU2001239856A1 (en) | 2001-09-03 |
| EP1263986A4 (fr) | 2005-02-23 |
| EP1263986A1 (fr) | 2002-12-11 |
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