WO2001062964A3 - A genetic determinant for malignant melanoma - Google Patents

A genetic determinant for malignant melanoma Download PDF

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Publication number
WO2001062964A3
WO2001062964A3 PCT/GB2001/000753 GB0100753W WO0162964A3 WO 2001062964 A3 WO2001062964 A3 WO 2001062964A3 GB 0100753 W GB0100753 W GB 0100753W WO 0162964 A3 WO0162964 A3 WO 0162964A3
Authority
WO
WIPO (PCT)
Prior art keywords
malignant melanoma
genetic determinant
screens
determining
absence
Prior art date
Application number
PCT/GB2001/000753
Other languages
French (fr)
Other versions
WO2001062964A2 (en
Inventor
Samantha Winsey
Neil Haldar
Fenella Wojnarowska
Kenneth Welsh
Original Assignee
Isis Innovation
Samantha Winsey
Neil Haldar
Fenella Wojnarowska
Kenneth Welsh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Samantha Winsey, Neil Haldar, Fenella Wojnarowska, Kenneth Welsh filed Critical Isis Innovation
Priority to AU2001233933A priority Critical patent/AU2001233933A1/en
Publication of WO2001062964A2 publication Critical patent/WO2001062964A2/en
Publication of WO2001062964A3 publication Critical patent/WO2001062964A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides genetic screens for use in determining susceptibility to malignant melanoma based on determining the presence or absence of one or more polymorphic variants of the XRCC3 gene. Reagent kits for use in such screens are also described.
PCT/GB2001/000753 2000-02-22 2001-02-22 A genetic determinant for malignant melanoma WO2001062964A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001233933A AU2001233933A1 (en) 2000-02-22 2001-02-22 A genetic determinant for malignant melanoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0004193.9 2000-02-22
GBGB0004193.9A GB0004193D0 (en) 2000-02-22 2000-02-22 A genetic determinant for malignant melanoma

Publications (2)

Publication Number Publication Date
WO2001062964A2 WO2001062964A2 (en) 2001-08-30
WO2001062964A3 true WO2001062964A3 (en) 2002-03-14

Family

ID=9886190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/000753 WO2001062964A2 (en) 2000-02-22 2001-02-22 A genetic determinant for malignant melanoma

Country Status (3)

Country Link
AU (1) AU2001233933A1 (en)
GB (1) GB0004193D0 (en)
WO (1) WO2001062964A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2504903A1 (en) * 2002-11-06 2004-05-27 Sequenom, Inc. Method for identifying risk of melanoma and treatments thereof
WO2005098034A1 (en) * 2004-04-08 2005-10-20 Hiltrud Brauch Ercc2 polymorphisms
JP4761389B2 (en) * 2004-04-09 2011-08-31 株式会社ジーンケア研究所 Cancer cell-specific apoptosis inducer targeting genes related to chromosome stabilization
CA2702169A1 (en) * 2007-10-12 2009-04-16 Decode Genetics Ehf Sequence variants for inferring human pigmentation patterns

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LIU NAN ET AL: "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.", MOLECULAR CELL, vol. 1, no. 6, May 1998 (1998-05-01), pages 783 - 793, XP001000712, ISSN: 1097-2765 *
PRICE E A ET AL: "Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.", SOMATIC CELL AND MOLECULAR GENETICS, vol. 23, no. 4, July 1997 (1997-07-01), pages 237 - 247, XP001000702, ISSN: 0740-7750 *
SHEN M RICHARD ET AL: "Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.", CANCER RESEARCH, vol. 58, no. 4, 15 February 1998 (1998-02-15), pages 604 - 608, XP000999161, ISSN: 0008-5472 *
WINSEY S ET AL: "A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 115, no. 3, September 2000 (2000-09-01), Abstracts for the 30th European Society for Dermatological Research Annual Meeting;Berlin, Germany; September 21-23, 2000, pages 538, XP001002656, ISSN: 0022-202X *

Also Published As

Publication number Publication date
WO2001062964A2 (en) 2001-08-30
AU2001233933A1 (en) 2001-09-03
GB0004193D0 (en) 2000-04-12

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