WO2001062908A3 - Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof - Google Patents

Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof

Info

Publication number
WO2001062908A3
WO2001062908A3 PCT/IL2001/000120 IL0100120W WO0162908A3 WO 2001062908 A3 WO2001062908 A3 WO 2001062908A3 IL 0100120 W IL0100120 W IL 0100120W WO 0162908 A3 WO0162908 A3 WO 0162908A3
Authority
WO
WIPO (PCT)
Prior art keywords
chimeric
methods
tcr
reagents
phage display
Prior art date
Application number
PCT/IL2001/000120
Other languages
French (fr)
Other versions
WO2001062908A2 (en
Inventor
Ahuva Nissim
Original Assignee
Ahuva Nissim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ahuva Nissim filed Critical Ahuva Nissim
Priority to AU2001232204A priority Critical patent/AU2001232204A1/en
Priority to EP01904292A priority patent/EP1259601A2/en
Publication of WO2001062908A2 publication Critical patent/WO2001062908A2/en
Publication of WO2001062908A3 publication Critical patent/WO2001062908A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention provides a chimeric phage display library, TCR phage display library, recombinant chimeric reagents, methods of making the libraries, methods for identifying recombinant reagents, oligonucleotides, linkers, tags, methods of purification, methods of increasing the avidity of recombinant reagents, methods of diagnosing and treating a subject with a disease or a pathogenic condition.
PCT/IL2001/000120 2000-02-22 2001-02-05 Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof WO2001062908A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001232204A AU2001232204A1 (en) 2000-02-22 2001-02-05 Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
EP01904292A EP1259601A2 (en) 2000-02-22 2001-02-05 Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51036100A 2000-02-22 2000-02-22
US09/510,361 2000-02-22

Publications (2)

Publication Number Publication Date
WO2001062908A2 WO2001062908A2 (en) 2001-08-30
WO2001062908A3 true WO2001062908A3 (en) 2002-04-25

Family

ID=24030435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000120 WO2001062908A2 (en) 2000-02-22 2001-02-05 Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof

Country Status (3)

Country Link
EP (1) EP1259601A2 (en)
AU (1) AU2001232204A1 (en)
WO (1) WO2001062908A2 (en)

Families Citing this family (36)

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ATE432290T1 (en) * 2002-11-09 2009-06-15 Immunocore Ltd T CELL RECEPTOR ßDISPLAYß
JP2006523437A (en) * 2002-12-03 2006-10-19 アヴィデックス リミテッド Receptor complex
GB0411771D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Nucleoproteins displaying native T cell receptor libraries
GB0411773D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex
KR101404512B1 (en) 2005-01-05 2015-01-29 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
AT503861B1 (en) * 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING T-CELL RECEPTORS
AT503889B1 (en) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
EP3241842B1 (en) 2007-06-26 2024-01-31 F-star Therapeutics Limited Display of binding agents
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
EP2258719A1 (en) * 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
EP3137100B1 (en) 2014-04-15 2023-12-20 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
MA49156A (en) 2014-12-23 2020-03-25 Immatics Biotechnologies Gmbh NEW PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA (HCC) AND OTHER CANCERS
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
CN108137688A (en) 2015-06-01 2018-06-08 基因医疗免疫疗法有限责任公司 The method for generating the antibody of anti-T cell receptor
US10858760B2 (en) 2015-06-01 2020-12-08 Medigene Immunotherapies Gmbh T cell receptor library
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
GB201522592D0 (en) 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
KR102319839B1 (en) 2015-12-23 2021-11-01 메디진 이뮤노테라피스 게엠바하 Novel generation of antigen-specific tcrs
GB201604953D0 (en) 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
KR102473964B1 (en) 2016-04-08 2022-12-06 이뮤노코어 리미티드 T cell receptor
KR102514213B1 (en) * 2016-12-16 2023-03-27 트위스트 바이오사이언스 코포레이션 Immune synaptic variant library and its synthesis
CN110366557B (en) 2016-12-23 2024-04-09 威特拉公司 Binding polypeptides and methods of making the same
GB201709866D0 (en) 2017-06-20 2017-08-02 Immunocore Ltd T cell receptors
US20210363216A1 (en) 2018-05-14 2021-11-25 Immunocore Limited Bifunctional binding polypeptides
WO2020018715A1 (en) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
GB201901305D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Specific binding molecules
GB201901306D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Multi-domain binding molecules
GB201904328D0 (en) 2019-03-28 2019-05-15 Immunocore Ltd Specific binding molecules
GB201915282D0 (en) 2019-10-22 2019-12-04 Immunocore Ltd Specific binding molecules
GB202006629D0 (en) 2020-05-05 2020-06-17 Immunocore Ltd Specific binding molecules
GB202010329D0 (en) 2020-07-06 2020-08-19 Immunocore Ltd Specific binding molecules
WO2023156663A1 (en) 2022-02-20 2023-08-24 Immunocore Limited Hiv-specific binding molecules and tcr
WO2024038165A1 (en) 2022-08-18 2024-02-22 Immunocore Ltd T cell receptor fusion proteins specific for mage a4
WO2024038198A1 (en) 2022-08-18 2024-02-22 Immunocore Limited Multi-domain binding molecules
WO2024038193A1 (en) 2022-08-18 2024-02-22 Immunocore Limited Multi-domain binding molecules
WO2024038183A1 (en) 2022-08-18 2024-02-22 Immunocore Limited Multi-domain binding molecules

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001047A1 (en) * 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1993003151A1 (en) * 1991-08-10 1993-02-18 Medical Research Council Treatment of cell populations
WO1993019163A1 (en) * 1992-03-18 1993-09-30 Yeda Research And Development Co, Ltd. Chimeric receptor genes and cells transformed therewith
WO1997035991A1 (en) * 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
WO1998039482A1 (en) * 1997-03-07 1998-09-11 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
WO1999020749A1 (en) * 1997-10-20 1999-04-29 Medical Research Council Method to screen phage display libraries with different ligands
WO1999057268A1 (en) * 1998-05-06 1999-11-11 Celltech Therapeutics Limited Chimeric receptors
EP1118661A1 (en) * 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001047A1 (en) * 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1993003151A1 (en) * 1991-08-10 1993-02-18 Medical Research Council Treatment of cell populations
WO1993019163A1 (en) * 1992-03-18 1993-09-30 Yeda Research And Development Co, Ltd. Chimeric receptor genes and cells transformed therewith
WO1997035991A1 (en) * 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
WO1998039482A1 (en) * 1997-03-07 1998-09-11 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
WO1999020749A1 (en) * 1997-10-20 1999-04-29 Medical Research Council Method to screen phage display libraries with different ligands
WO1999057268A1 (en) * 1998-05-06 1999-11-11 Celltech Therapeutics Limited Chimeric receptors
EP1118661A1 (en) * 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ARDEN BERNHARD ET AL: "Human T-cell receptor variable gene segment families.", IMMUNOGENETICS, vol. 42, no. 6, 1995, pages 455 - 500, XP001024377, ISSN: 0093-7711 *
ESHHAR Z ET AL: "SPECIFIC ACTIVATION AND TARGETING OF CYTOTOXIC LYMPHOCYTES THROUGH CHIMERIC SINGLE CHAINS CONSISTING OF ANTIBODY-BINDING DOMAINS AND THE GAMMA OR ZETA SUBUNITS OF THE IMMUNOGLOBULIN AND T-CELL RECEPTORS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 90, no. 2, 15 January 1993 (1993-01-15), pages 720 - 724, XP002009770, ISSN: 0027-8424 *
GASCOIGNE N ET AL: "Secretion of a chimeric T-cell receptor-immunoglobulin protein", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 84, no. 9, May 1987 (1987-05-01), pages 2936 - 2940, XP002149784, ISSN: 0027-8424 *
HOOGENBOOM H R ET AL: "MULTI-SUBUNIT PROTEINS ON THE SURFACE OF FILAMENTOUS PHAGE: METHODOLOGIES FOR DISPLAYING ANTIBODY (FAB) HEAVY AND LIGHT CHAINS", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 19, no. 15, 1991, pages 4133 - 4137, XP001019229, ISSN: 0305-1048 *
KIEKE MICHELE C ET AL: "Selection of functional T cell receptor mutants from a yeast surface-display library.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 10, 11 May 1999 (1999-05-11), May 11, 1999, pages 5651 - 5656, XP002177390, ISSN: 0027-8424 *
MARIUZZA R ET AL: "Secretion of a homodimeric ValphaCkappa T-cell receptor-immunoglobulin chimeric protein", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 264, no. 13, 5 May 1989 (1989-05-05), pages 7310 - 7316, XP002149783, ISSN: 0021-9258 *
ONDA T ET AL: "A PHAGE DISPLAY SYSTEM FOR DETECTION OF T CELL RECEPTOR-ANTIGEN INTERACTIONS", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 32, no. 17/18, 1995, pages 1387 - 1397, XP002912582, ISSN: 0161-5890 *
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Also Published As

Publication number Publication date
EP1259601A2 (en) 2002-11-27
WO2001062908A2 (en) 2001-08-30
AU2001232204A1 (en) 2001-09-03

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