WO2001062374A3 - Verfahren zur herstellung von nanosuspensionen - Google Patents

Verfahren zur herstellung von nanosuspensionen Download PDF

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Publication number
WO2001062374A3
WO2001062374A3 PCT/EP2001/001340 EP0101340W WO0162374A3 WO 2001062374 A3 WO2001062374 A3 WO 2001062374A3 EP 0101340 W EP0101340 W EP 0101340W WO 0162374 A3 WO0162374 A3 WO 0162374A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow rate
relates
rate ranging
partial streams
nanosuspensions
Prior art date
Application number
PCT/EP2001/001340
Other languages
English (en)
French (fr)
Other versions
WO2001062374A2 (de
Inventor
Bernd Kuehn
Kai Christian Juergens
Georg Wiessmeier
Original Assignee
Bayer Ag
Bernd Kuehn
Kai Christian Juergens
Georg Wiessmeier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bernd Kuehn, Kai Christian Juergens, Georg Wiessmeier filed Critical Bayer Ag
Priority to AU2001239243A priority Critical patent/AU2001239243A1/en
Publication of WO2001062374A2 publication Critical patent/WO2001062374A2/de
Publication of WO2001062374A3 publication Critical patent/WO2001062374A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/51—Methods thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4335—Mixers with a converging-diverging cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3045—Micromixers using turbulence on microscale
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/916—Turbulent flow, i.e. every point of the flow moves in a random direction and intermixes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/045—Numerical flow-rate values

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Verfahren zur Herstellung von Nanosuspensionen, bei dem mindestens zwei dosierte Teilströme (25, 26) so zusammen gebracht werden, dass sie einer durch Turbulenz bedingten Durchmischung unterliegen. Die Teilströme haben dabei eine Flussrate im Bereich von 0.1 bis 500 ml/h und der Mischstrom eine Gesamtflussrate im Bereich von 1 ml/h bis 500 ml/h. Bei der turbulenten Durchmischung entstehen Partikel mit einer Grösse von 0,1 bis 5000 nm. Ein weiterer Gegenstand der Erfindung ist ein Verfahren zur in-situ-Formulierung einer Arzneistoffsuspension, wobei die Arzneistoffsuspension in-line appliziert wird.
PCT/EP2001/001340 2000-02-21 2001-02-08 Verfahren zur herstellung von nanosuspensionen WO2001062374A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001239243A AU2001239243A1 (en) 2000-02-21 2001-02-08 Method for producing nanosuspensions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10007816.8 2000-02-21
DE10007816A DE10007816A1 (de) 2000-02-21 2000-02-21 Verfahren zur Herstellung von Nanosuspensionen

Publications (2)

Publication Number Publication Date
WO2001062374A2 WO2001062374A2 (de) 2001-08-30
WO2001062374A3 true WO2001062374A3 (de) 2002-03-14

Family

ID=7631688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/001340 WO2001062374A2 (de) 2000-02-21 2001-02-08 Verfahren zur herstellung von nanosuspensionen

Country Status (3)

Country Link
AU (1) AU2001239243A1 (de)
DE (1) DE10007816A1 (de)
WO (1) WO2001062374A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
DE10124952A1 (de) * 2001-05-21 2002-12-12 Bayer Ag Verfahren zur Herstellung von Nanodispersionen
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
DE10206083B4 (de) * 2002-02-13 2009-11-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zum Erzeugen monodisperser Nanotropfen sowie mikrofluidischer Reaktor zum Durchführen des Verfahrens
EP1452225B1 (de) * 2003-02-26 2008-09-10 National Institute of Advanced Industrial Science and Technology Herstellung von Nanopartikeln
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
US7229497B2 (en) * 2003-08-26 2007-06-12 Massachusetts Institute Of Technology Method of preparing nanocrystals
DE602004019169D1 (de) * 2003-09-22 2009-03-12 Fujifilm Corp Feine organische Pigmentpartikel und Verfahren zu deren Herstellung
DE102005003965A1 (de) * 2005-01-27 2006-08-10 Ehrfeld Mikrotechnik Gmbh Mikromischer
DE102006050748A1 (de) * 2006-10-27 2008-04-30 Evonik Degussa Gmbh Nanoskalige Partikel enthaltende Lackbindemittel mit verbesserter Kratzfestigkeit und Flexibilität, Verfahren zu deren Herstellung sowie diese enthaltende hochtransparente Lacke
EP2033707B1 (de) * 2007-09-07 2011-03-09 Merck Patent GmbH Verfahren zur Herstellung einer homogenen flüssigen Mischung
US20180317523A1 (en) * 2015-04-22 2018-11-08 Basf Se Nanoparticles, nanoemulsions and their formation with mixing chamber micronization
CN108745015B (zh) * 2018-06-29 2020-09-08 扬州大学 一种纳米级分散液的制备方法与装置
CN114522556B (zh) * 2022-01-27 2023-11-24 扬州大学 一种大量、连续制备免水洗凝胶洗手液的微混合装置及微混合方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE19541265A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Verfahren zur Herstellung von Dispersionen und zur Durchführung chemischer Reaktionen mit disperser Phase
EP0860201A2 (de) * 1996-12-27 1998-08-26 Genus Corporation Hochgeschwindigkeits - Kollisions - Reaktionsverfahren
DE19757224A1 (de) * 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE19541265A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Verfahren zur Herstellung von Dispersionen und zur Durchführung chemischer Reaktionen mit disperser Phase
EP0860201A2 (de) * 1996-12-27 1998-08-26 Genus Corporation Hochgeschwindigkeits - Kollisions - Reaktionsverfahren
DE19757224A1 (de) * 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation

Also Published As

Publication number Publication date
WO2001062374A2 (de) 2001-08-30
DE10007816A1 (de) 2001-09-06
AU2001239243A1 (en) 2001-09-03

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