WO2001058462A3 - Models, methods and materials relating to clinical conditions associated with reactive oxygen species - Google Patents

Models, methods and materials relating to clinical conditions associated with reactive oxygen species Download PDF

Info

Publication number
WO2001058462A3
WO2001058462A3 PCT/GB2001/000571 GB0100571W WO0158462A3 WO 2001058462 A3 WO2001058462 A3 WO 2001058462A3 GB 0100571 W GB0100571 W GB 0100571W WO 0158462 A3 WO0158462 A3 WO 0158462A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
models
conditions associated
oxygen species
reactive oxygen
Prior art date
Application number
PCT/GB2001/000571
Other languages
French (fr)
Other versions
WO2001058462A2 (en
Inventor
Joseph F Clark
Nicola Thomson
Original Assignee
Medical Res Council Technology
Joseph F Clark
Nicola Thomson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council Technology, Joseph F Clark, Nicola Thomson filed Critical Medical Res Council Technology
Priority to AU2001232081A priority Critical patent/AU2001232081A1/en
Publication of WO2001058462A2 publication Critical patent/WO2001058462A2/en
Publication of WO2001058462A3 publication Critical patent/WO2001058462A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)

Abstract

The present invention relates to a method for the preparation of an extract containing a vasoactive factor from a biological sample such as preeclamptic placenta or blood. The method comprises treating the sample with an alcohol solution of an organic acid, maintaining acidosis and minimising exposure of the extract to air.Compositions, methods and uses related to this extraction method are provided.
PCT/GB2001/000571 2000-02-11 2001-02-12 Models, methods and materials relating to clinical conditions associated with reactive oxygen species WO2001058462A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001232081A AU2001232081A1 (en) 2000-02-11 2001-02-12 Models, methods and materials relating to clinical conditions associated with reactive oxygen species

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0003225.0A GB0003225D0 (en) 2000-02-11 2000-02-11 Models, methods and materials relating to clinical conditions associated with reactive oxygen species
GB0003225.0 2000-02-11

Publications (2)

Publication Number Publication Date
WO2001058462A2 WO2001058462A2 (en) 2001-08-16
WO2001058462A3 true WO2001058462A3 (en) 2002-02-14

Family

ID=9885458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/000571 WO2001058462A2 (en) 2000-02-11 2001-02-12 Models, methods and materials relating to clinical conditions associated with reactive oxygen species

Country Status (3)

Country Link
AU (1) AU2001232081A1 (en)
GB (1) GB0003225D0 (en)
WO (1) WO2001058462A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039353A1 (en) * 1996-04-18 1997-10-23 Medical Research Council Oxidative metabolism in smooth muscle cells: methods and materials relating thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039353A1 (en) * 1996-04-18 1997-10-23 Medical Research Council Oxidative metabolism in smooth muscle cells: methods and materials relating thereto

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEARCHELL MELISSA C ET AL: "Vascular smooth muscle oxygen consumption is reversibly stimulated by sera from women with preeclampsia.", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 179, no. 6 PART 1, December 1998 (1998-12-01), pages 1534 - 1538, XP001016328, ISSN: 0002-9378 *
THOMSON NICOLA F ET AL: "Placental extracts and serum from preeclamptic women show similar vasoactive effects.", FASEB JOURNAL, vol. 14, no. 4, 15 March 2000 (2000-03-15), Annual Meeting of Professional Research Scientists: Experimental Biology 2000;San Diego, California, USA; April 15-18, 2000, pages A462, XP002176756, ISSN: 0892-6638 *
THOMSON NICOLA F ET AL: "The effects of placental extracts from normotensive and preeclamptic women on vasoconstriction and oxidative metabolism.", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 183, no. 1, July 2000 (2000-07-01), pages 206 - 210, XP001016340, ISSN: 0002-9378 *

Also Published As

Publication number Publication date
WO2001058462A2 (en) 2001-08-16
AU2001232081A1 (en) 2001-08-20
GB0003225D0 (en) 2000-04-05

Similar Documents

Publication Publication Date Title
HK1055446A1 (en) Method for isolation of rna from formalin-fixed paraffin-embedded tissue specimens
WO1997005248A3 (en) Solution containing chaotropic agent and process using it for isolation of dna, rna and proteins
DE69942351D1 (en) Methods and reagents for the maintenance of RNA in cells and tissues
KR20070115874A (en) Reagents and methods for storage and processing of biological samples for dna analysis
WO2006065442A3 (en) Methods and compositions for a microemulsion-based tissue treatment
WO2004063704A3 (en) Vitamin d assay
ATE469219T1 (en) COMPOSITIONS, METHODS AND REAGENTS FOR NUCLEIC ACID ISOLATION USING SURFACE-ACTIVE SUBSTANCES AND PROTEASES
WO2005012879A3 (en) Methods and compositions for preparing tissue samples for rna extraction
EP1944364A4 (en) Rna extraction method and rna detection method
EP1440320A4 (en) Histological tissue specimen treatment
DE60216447D1 (en) DEVICE AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES
DE69828392D1 (en) Process for the preparation of a standard diagnostic gene transcription pattern
WO2000020846A8 (en) Method for imaging tissue
WO2003016464A3 (en) Cancer specific oligosaccharide sequences and use thereof
WO2001082793A3 (en) Method and device for testing a sample of fresh whole blood
WO2005054466A3 (en) Methods and compositions for preparing rna from a fixed sample
DE50209503D1 (en) PROCESS FOR EXTRACTION AND ANALYSIS OF INGREDIENTS FROM ORGANIC MATERIAL
WO2005042060A3 (en) Method and composition comprising pyruvate, inosine, adenine, phosphate and an aziridino compound for treating a biological sample
BRPI0401650A (en) Rapid RNA Extraction from Cells and Tissues
WO2004072229A3 (en) Chemical treatment of biological samples for nucleic acid extraction and kits therefor
HK1064738A1 (en) Method for sample identification in a mammal as well as a kit for performing this method
CA2407684A1 (en) Hematology blood control and method for preparation of same
WO2000050564A3 (en) Method for extracting dna from dried specimens
WO2001058462A3 (en) Models, methods and materials relating to clinical conditions associated with reactive oxygen species
WO2001048476A3 (en) Extraction of biological components from body fluids

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP