WO2001058284A1 - Pharmaceutical composition for muscular anabolism - Google Patents
Pharmaceutical composition for muscular anabolism Download PDFInfo
- Publication number
- WO2001058284A1 WO2001058284A1 PCT/NL2001/000112 NL0100112W WO0158284A1 WO 2001058284 A1 WO2001058284 A1 WO 2001058284A1 NL 0100112 W NL0100112 W NL 0100112W WO 0158284 A1 WO0158284 A1 WO 0158284A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- protein
- anabolic
- daily dose
- per daily
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 18
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 15
- 230000003387 muscular Effects 0.000 title claims abstract description 9
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000018102 proteins Nutrition 0.000 claims abstract description 23
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 23
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 23
- 230000001195 anabolic effect Effects 0.000 claims abstract description 17
- 229960003624 creatine Drugs 0.000 claims abstract description 17
- 239000006046 creatine Substances 0.000 claims abstract description 17
- 239000000758 substrate Substances 0.000 claims abstract description 11
- 239000003999 initiator Substances 0.000 claims abstract description 10
- 235000021120 animal protein Nutrition 0.000 claims abstract description 6
- 239000003102 growth factor Substances 0.000 claims abstract description 5
- 210000003022 colostrum Anatomy 0.000 claims description 16
- 235000021277 colostrum Nutrition 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 150000001720 carbohydrates Chemical class 0.000 claims description 14
- 235000014633 carbohydrates Nutrition 0.000 claims description 14
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 14
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 14
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 10
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- 229930182817 methionine Natural products 0.000 claims description 8
- 235000016709 nutrition Nutrition 0.000 claims description 8
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 8
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 7
- 229960000304 folic acid Drugs 0.000 claims description 7
- 235000019152 folic acid Nutrition 0.000 claims description 7
- 239000011724 folic acid Substances 0.000 claims description 7
- 229940011671 vitamin b6 Drugs 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 6
- 239000013589 supplement Substances 0.000 claims description 6
- 235000019158 vitamin B6 Nutrition 0.000 claims description 6
- 239000011726 vitamin B6 Substances 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 235000001055 magnesium Nutrition 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 235000016804 zinc Nutrition 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- AXFYFNCPONWUHW-UHFFFAOYSA-N 3-hydroxyisovaleric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 claims description 4
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 4
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 4
- 229960003987 melatonin Drugs 0.000 claims description 4
- 108010000912 Egg Proteins Proteins 0.000 claims description 3
- 150000005693 branched-chain amino acids Chemical class 0.000 claims description 3
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 229930003779 Vitamin B12 Natural products 0.000 claims description 2
- 235000019163 vitamin B12 Nutrition 0.000 claims description 2
- 239000011715 vitamin B12 Substances 0.000 claims description 2
- 102000014171 Milk Proteins Human genes 0.000 claims 2
- 108010011756 Milk Proteins Proteins 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 235000021239 milk protein Nutrition 0.000 claims 2
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 229940024606 amino acid Drugs 0.000 description 16
- 235000001014 amino acid Nutrition 0.000 description 16
- 150000001413 amino acids Chemical class 0.000 description 16
- 239000000047 product Substances 0.000 description 15
- 210000003205 muscle Anatomy 0.000 description 12
- 239000000843 powder Substances 0.000 description 11
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 10
- 229960004452 methionine Drugs 0.000 description 9
- 108010046377 Whey Proteins Proteins 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 229960003136 leucine Drugs 0.000 description 7
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 235000013350 formula milk Nutrition 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 235000018977 lysine Nutrition 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- 102000007544 Whey Proteins Human genes 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000005862 Whey Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 description 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 3
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 3
- 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 description 3
- 239000004395 L-leucine Substances 0.000 description 3
- 235000019454 L-leucine Nutrition 0.000 description 3
- 229920002774 Maltodextrin Polymers 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 229960001456 adenosine triphosphate Drugs 0.000 description 3
- 239000005018 casein Substances 0.000 description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
- 235000021240 caseins Nutrition 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 229960004799 tryptophan Drugs 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000021119 whey protein Nutrition 0.000 description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- 150000008575 L-amino acids Chemical class 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 2
- 229930195722 L-methionine Natural products 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 235000019742 Vitamins premix Nutrition 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000003851 biochemical process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- 235000000639 cyanocobalamin Nutrition 0.000 description 2
- 239000011666 cyanocobalamin Substances 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229910017053 inorganic salt Inorganic materials 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000012263 liquid product Substances 0.000 description 2
- 229960003646 lysine Drugs 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- 229940076788 pyruvate Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 2
- AEDORKVKMIVLBW-BLDDREHASA-N 3-oxo-3-[[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methoxy]oxan-2-yl]methoxy]propanoic acid Chemical compound OCC1=C(O)C(C)=NC=C1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O1 AEDORKVKMIVLBW-BLDDREHASA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000008934 Muscle Proteins Human genes 0.000 description 1
- 108010074084 Muscle Proteins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 230000037147 athletic performance Effects 0.000 description 1
- 102000023732 binding proteins Human genes 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 235000015496 breakfast cereal Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- -1 casein Chemical compound 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- 235000019543 dairy drink Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940120503 dihydroxyacetone Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000002270 ergogenic effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000020610 powder formula Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 235000021134 protein-rich food Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000011649 selenium Nutrition 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/832—Milk; colostrum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/833—Whey; cheese
Definitions
- the invention is concerned with pharmaceutical or nutritional compositions suitable for increasing muscular mass ("lean body mass”), e.g. for athletes, and for preventing loss of lean body mass that may occur in periods of rest and during recovery from disease.
- lean body mass can be increased without increase body fat by administration of a supplement containing creatine, taurine, and ribonucleic acid, optionally with carbohydrate for enhancing cellular uptake of these ingredients.
- WO 98/43617 discloses a dietary supplement comprising L-carnitine, coenzyme Q10 and taurine useful in the correction of the abnormality in mitochondrial energetics occurring in cardiac failure and certain other diseases. It further discloses a high protein, high calorie nutritional feeding supplement comprising these three nutrients together with cysteine, vitamin E, vitamin C, selenium, and thiamine. The protein fraction can comprise of normal (i.e. denatured) whey proteins, 1 : 1 with casein.
- WO 95/10192 discloses a nutritional drink containing colostrum, for the purpose of improving physical performance and recovery. The colostrum is defatted and de- caseinated, and sterilised by filtration.
- WO 99/56758 describes a food composition for use in changing body composition (increased lean tissue) and/or physical work capacity, which contains undenatured colostrum, in particular colostrum derived growth factors and colostrum- derived casein.
- the composition may further contain vitamins minerals, amino acids, and carbohydrates.
- Muscle consists of proteins, like myosine and actin, lipids and carbohydrates. Skeletal muscle tissue is continuously broken off and replaced in a dynamic process that depends on mechanical damage, exercise and feeding status at a particular point in time.
- Sequential use means that the different components can be administered separately during the day, but they must be consumed during the same day.
- a product with one or more facilitators is consumed first, followed by consumption, e.g. 2 hours after consumption of the first product, of an effective amount of substrate and initiator in the same product.
- all three types of components are consumed simultaneously in one product.
- the invention pertains to pharmaceutical and/or nutritional compositions suitable for enhancing muscular anabolism, i.e. production of muscle tissue or reduction of loss of muscle tissue.
- the compositions according to the invention comprise an initiator for muscular tissue production, a facilitator for biosynthesis, and a substrate. They furthermore comprise a facilitator, including creatine or a functional equivalent, and optionally further components facilitating tissue production, and also a substrate comprising e.g. carbohydrates, amino acids etc.
- the products can have a powdered structure, packed in sachets or cans or similar reservoirs. Other dry forms that are equally suitable are cereals and bars.
- the product can also have the form of a drink, e.g. based on a dairy drink (milk, whey) or fruit juice (orange, apple, grape). For liquid products it is advantageous to let it have a pH below 4.2 in order to stabilize some of the active components.
- the product can also have the form of a paste or spread or sauce.
- the initiators also referred to as triggering substances or triggers
- the initiators are components that start up the anabolic processes.
- Examples are anabolic growth factors like Insulin-Like Growth Factor (IGF-1). These must be present as part of an extract of a protein-rich food ingredient, in particular in an extract from a proteinaceous material of animal origin, like milk, blood or egg.
- IGF-1 Insulin-Like Growth Factor
- Undenatured whey and especially undenatured colostrum in particular bovine colostrum comprises a variety of anabolic trigger substances.
- the high effectivity of whey and colostrum that was found may also be explained by the presence of components that increase the bioavailability of the initiator components.
- Suitable methods for obtaining such products avoiding substantial heat treatment include filtration and centrifugal techniques.
- the amount of extract can be as low as 5 mg per daily dose, if a high degree of purification of the triggering substances from the proteinaceous material is obtained.
- bovine colostrum is used as sole source for triggering substances, at least 5 g of the product, that is obtained by using the method disclosed in WO 97/16977, should be included in a daily dose according to the invention.
- insulinotrophic components like digestible carbohydrates and arginine and lysine can further enhance the triggering activity of extracts of animal proteins.
- Arginine and lysine should be included in amounts of more than 1.0 g and preferably more than 1.5 g per daily dose.
- Carbohydrates are preferably glucose polymers like maltodextrins and should be present in an amount of more than 4 g and preferably more than 8 g. Substrates
- Proteins and amino acids can be expressed as protein equivalents (PE).
- PE protein equivalents
- methionine, lysine and leucine additional amounts of these amino acids can be included. This can be done by including peptides, or amino acid complexes or free amino acids in the formula. Preferably free amino acids are used, especially those in the L-form.
- the amounts of methionine that are included per daily serving should exceed 0.2 g (9.4% N: 0.12 g PE) and preferably exceed 0.5 g; the preferred range is 1-6 g Met.
- the amount of methionine is more than 2.8 g per 100 g protein equivalents and in particular in the range 3.0-5.0.
- the amount of lysine per daily serving should be more than 1.0 g (19.6% N: 1.3 g PE) and preferably more than 2.0 g, e.g. 2.5 - 15.0 g. Calculated per lOOg protein equivalents, the amount of lysine should be more than 8.3 g, and in particular in the range 8.5-11.
- the amount of leucine per daily serving should be more than 2.0 g (10.4% N: 1.3 g PE) and preferably more than 3.0 g, e.g. 3.5 - 20 g.
- BCAA branched chain amino acids
- the amount of L-tryptophan should be relatively high.
- the ratio Trp/BCAA should be higher than 0.055, preferably in the range of 0.06-0.2 and in particular be in the range of 0.07-0.13.
- persons that suffer from disease frequently appear to experience problems with maintaining nitrogen balance. By consuming the above-mentioned types and amounts of substrates their capacity to synthesise muscle tissue is maximally supported.
- lean body tissue can only be synthesised when sufficient energy is available and sufficient amounts of cofactors are available as facilitator of the anabolic biochemical processes.
- Intracellular energy should be available in the form of adenosine tri-phosphate (ATP).
- Creatine phosphate (CP) is able to provide "energised phosphate" to ADP, which restores ATP levels once they have been used for labour or biochemical processes. It is therefore especially advantageous to include in the formulation a source of both energy, in the form of digestible carbohydrates, and creatine.
- Krebs eye le intermediates such as citrate and Krebs cycle precursors, such as pyruvate, glutamate, j lutamine, can be used.
- the amount of digestible carbohydrates should be above 4 g per daily dose and preferably more than 10 g per cay. That of creatine should be above 1.0 g per daily dose and preferably more than 2.0 g, for example 8 g.
- Creatine can be the salt creatine, creatine phosphate, or functional and stable equivalents thereof, including acid addition salts, metal and ammonium salts, hydrolysable esters etc.
- vitamin B6 should be fortified to ensure a consumption of at least 1.8 mg vit. B6 per lOOg protein that is consumed.
- the high volume of protein that is normally consumed by body builders ensures a load of methionine that should be handled appropriately in order to have only moderate increases in plasma levels of homocysteine. It is therefore recommended to include folic acid, vitamin B12, vitamin B6, zinc and magnesium in the formula, because deficiencies of one or more of these components frequently occur, while they are mandatory for homeostasis of homocysteine loads.
- Vitamin B6 can e.g. have the form of pyridoxine or pyridoxal; folic acid can be in the monoglutamate form; zinc can be administered as salt, e.g. as zinc carbonate; magnesium can have the form of an inorganic salt like magnesium carbonate.
- a further improvement of the product can be obtained by including in the product one of the metabolites of leucine, especially beta-hydroxy-beta-methylbutyrate (HMB).
- HMB beta-hydroxy-beta-methylbutyrate
- the latter compound can be included in an amount of 1-20 g per daily serving, in particular in the range 2-5 g per day.
- the component can be included as pure substance or as inorganic salt such as the calcium salt, or any other functional equivalent.
- Other components like yeast, carnitine, pyruvate, dihydroxyacetone, glutamine, ubiquinone (especially CoQIO) and other vitamins and minerals can be included as well. It is especially preferred to include melatonin, which supports the anabolic function of the composition.
- Table 1 shows the scope of the products according to the invention. Table 1: Components according to the invention
- Example 1 Bar for body building purposes An extract for isolating anabolic components from colostrum is prepared by applying the centrifugation process as described in WO 97/16977. The liquid phase is consequently purified by elution over a strong anionic exchanger. The liquid is then freeze-dried. The bar is prepared by using methods that are known in the art that ensure that per bar of 30g weight is present: 100 mg of colostrum powder produced as given above,
- Example 3 Powder packed as in example 2, consisting per lOOg formula of: 33 g undenatured egg white powder
- a mineral/vitamin premix that comprises 1250 ug folic acid, 10 mg pyridoxine, 7.5 ug cyanocobalamine, 75 mg zinc, 10 mg copper and 400 mg magnesium
- a mineral/vitamin premix that comprises 1250 ug folic acid, 10 mg pyridoxine, 7.5 ug cyanocobalamine, 75 mg zinc, 10 mg copper and 400 mg magnesium
- Per day about 25 g of powder is consumed e.g. suspended in 200 ml orange juice.
- Example 4 Powdered product for body building, that consists per 100 g formula of 72 g undenatured whey protein powder, providing 43 g protein and 21 g lactose
- Example 5 Liquid product obtained by preblending the powder of example 3 in orange juice.
- Example 7 Supplement The following components were combined an the amounts indicated for a daily dose: 30 g bovine colostrum 36 g carbohydrates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2398990A CA2398990C (en) | 2000-02-10 | 2001-02-12 | Pharmaceutical composition for muscular anabolism |
DE60140426T DE60140426D1 (en) | 2000-02-10 | 2001-02-12 | PHARMACEUTICAL COMPOSITION FOR MUSCLE ANABOLISM |
AU3780901A AU3780901A (en) | 2000-02-10 | 2001-02-12 | Pharmaceutical composition for muscular anabolism |
AU2001237809A AU2001237809B2 (en) | 2000-02-10 | 2001-02-12 | Pharmaceutical composition for muscular anabolism |
AT01910231T ATE447858T1 (en) | 2000-02-10 | 2001-02-12 | PHARMACEUTICAL COMPOSITION FOR MUSCLE ANABOLISM |
EP01910231A EP1253830B1 (en) | 2000-02-10 | 2001-02-12 | Pharmaceutical composition for muscular anabolism |
HK03100252.0A HK1048050B (en) | 2000-02-10 | 2003-01-10 | Pharmaceutical composition for muscular anabolism |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/500,802 | 2000-02-10 | ||
US09/500,802 US6521591B1 (en) | 2000-02-10 | 2000-02-10 | Pharmaceutical composition for muscular anabolism |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001058284A1 true WO2001058284A1 (en) | 2001-08-16 |
Family
ID=23990994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2001/000112 WO2001058284A1 (en) | 2000-02-10 | 2001-02-12 | Pharmaceutical composition for muscular anabolism |
Country Status (9)
Country | Link |
---|---|
US (1) | US6521591B1 (en) |
EP (1) | EP1253830B1 (en) |
AT (1) | ATE447858T1 (en) |
AU (2) | AU2001237809B2 (en) |
CA (1) | CA2398990C (en) |
DE (1) | DE60140426D1 (en) |
ES (1) | ES2336764T3 (en) |
HK (1) | HK1048050B (en) |
WO (1) | WO2001058284A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004056208A1 (en) * | 2002-12-20 | 2004-07-08 | Nutricia N.V. | Stimulation of in vivo production of proteins with formulation comprising leucine |
EP1642559A2 (en) * | 2000-07-06 | 2006-04-05 | Beiersdorf AG | Use of creatine and/or creatine derivatives in cosmetic or dermatological preparations |
DE102005028446A1 (en) * | 2005-06-17 | 2006-12-28 | Sibylle E. Bauer | Composition, preferably dietary supplements or dietetic food, useful e.g. to increase the efficiency and well-being of a healthy person, comprises colostrum and at least a ketocarboxylic acid |
EP1781334A2 (en) * | 2004-08-25 | 2007-05-09 | Mtor Formulations Ltd. | Compositions and methods for activating protein synthesis and deactivating catabolic processes in skeletal muscle |
WO2007056176A2 (en) * | 2005-11-03 | 2007-05-18 | Southwest Immunology, Inc. | Compositions for preventing and reducing delayed onset muscle soreness |
CN101791127A (en) * | 2010-03-05 | 2010-08-04 | 北京康比特体育科技股份有限公司 | Muscle protection composite containing HMbeta |
CN102711525A (en) * | 2010-01-29 | 2012-10-03 | 雅培制药有限公司 | Nutritional emulsions comprising calcium HMB and soluble protein |
US8916217B2 (en) | 2010-01-29 | 2014-12-23 | Abbott Laboratories | Aseptically packaged nutritional liquids comprising HMB |
US9241508B2 (en) | 2010-01-29 | 2016-01-26 | Abbott Laboratories | Nutritional emulsions comprising calcium HMB |
US9521859B2 (en) | 2010-06-10 | 2016-12-20 | Normanella T. Dewille | Substantially clear nutritional liquids comprising calcium HMB and soluble protein |
US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
US20190216821A1 (en) * | 2016-02-11 | 2019-07-18 | Nutrition 21, Llc | Chromium Containing Compositions for Improving Health and Fitness |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7744930B2 (en) * | 2002-11-22 | 2010-06-29 | Shaklee Corporation | Compositions, methods and kits for enhancing weight loss while inhibiting loss of lean body mass |
US20050143343A1 (en) * | 2003-12-30 | 2005-06-30 | Nerenberg Arnold P. | Nutritional supplement for enhancing the production and effect of natural human growth hormone |
US7799817B2 (en) * | 2004-02-20 | 2010-09-21 | Lifescape Biosciences Inc | Compositions and methods for sleep regulation |
US20050215640A1 (en) * | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
US20060013889A1 (en) * | 2004-07-16 | 2006-01-19 | Playford Raymond J | Colostrum-based treatment for irritable bowel syndrome |
US7426440B2 (en) * | 2004-09-24 | 2008-09-16 | Nutritional Bioscience Ltd. | Repair and protection factor scoring method for bioactive agents |
US20060068022A1 (en) * | 2004-09-29 | 2006-03-30 | Playford Raymond J | Bioactive agent compositions for repair of cell injuries |
CA2537647A1 (en) * | 2005-03-01 | 2006-09-01 | Six Star Formulations Ltd. | Supplemental dietary composition for supporting muscle growth, recovery and strength |
CN102225060A (en) | 2005-12-19 | 2011-10-26 | 雅培制药有限公司 | Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type 1 and type 2 cytokine production |
CN101524155B (en) * | 2009-04-20 | 2012-10-10 | 北京康比特体育科技股份有限公司 | Amino acid composition |
RU2012125879A (en) * | 2010-01-29 | 2014-03-10 | Эбботт Лэборетриз | NUTRITIONAL POWDERS CONTAINING DRIED SPRAY OF BETA-HYDROXY-BETA-METHYLBUTYRATE (GMB) |
EP2926669B1 (en) | 2014-04-02 | 2017-05-24 | AlzChem AG | Creatine protein matrix and method for manufacturing the same |
JOP20190146A1 (en) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | Amino acid compositions and methods for the treatment of liver diseases |
CN111295187A (en) | 2017-08-14 | 2020-06-16 | 胺细拉健康公司 | Amino acid composition for treating liver diseases |
CN112839643A (en) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | Compositions and methods for treating fat infiltration in muscle |
TWI737987B (en) * | 2019-04-23 | 2021-09-01 | 豐華生物科技股份有限公司 | Use of lactic acid bacteria in preparaing a composition for increasing exercise performance and anti-fatigue |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726146A (en) * | 1994-12-06 | 1998-03-10 | Natural Supplement Association, Incorporated | Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass |
WO1998043617A2 (en) * | 1997-03-27 | 1998-10-08 | Sole Michael J | Nutritional composition for improvements in cell energetics |
EP0875155A1 (en) * | 1997-05-01 | 1998-11-04 | N.V. Nutricia | Peri-operative drink |
WO1999056758A1 (en) * | 1998-04-30 | 1999-11-11 | Northfield Laboratories Pty. Ltd. | A food composition and method of using same |
WO1999064022A1 (en) * | 1998-06-10 | 1999-12-16 | Crum Albert B | Prophylactic and therapeutic nutritional supplement for creation/maintenance of health-protective intestinal microflora and enhancement of the immune system |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0347890B1 (en) * | 1988-06-22 | 1993-03-17 | Roussel Morishita Co., Ltd. | Amino acid nutrient compositions |
-
2000
- 2000-02-10 US US09/500,802 patent/US6521591B1/en not_active Expired - Lifetime
-
2001
- 2001-02-12 DE DE60140426T patent/DE60140426D1/en not_active Expired - Lifetime
- 2001-02-12 WO PCT/NL2001/000112 patent/WO2001058284A1/en active IP Right Grant
- 2001-02-12 AU AU2001237809A patent/AU2001237809B2/en not_active Ceased
- 2001-02-12 CA CA2398990A patent/CA2398990C/en not_active Expired - Fee Related
- 2001-02-12 AT AT01910231T patent/ATE447858T1/en not_active IP Right Cessation
- 2001-02-12 ES ES01910231T patent/ES2336764T3/en not_active Expired - Lifetime
- 2001-02-12 EP EP01910231A patent/EP1253830B1/en not_active Revoked
- 2001-02-12 AU AU3780901A patent/AU3780901A/en active Pending
-
2003
- 2003-01-10 HK HK03100252.0A patent/HK1048050B/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726146A (en) * | 1994-12-06 | 1998-03-10 | Natural Supplement Association, Incorporated | Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass |
WO1998043617A2 (en) * | 1997-03-27 | 1998-10-08 | Sole Michael J | Nutritional composition for improvements in cell energetics |
EP0875155A1 (en) * | 1997-05-01 | 1998-11-04 | N.V. Nutricia | Peri-operative drink |
WO1999056758A1 (en) * | 1998-04-30 | 1999-11-11 | Northfield Laboratories Pty. Ltd. | A food composition and method of using same |
WO1999064022A1 (en) * | 1998-06-10 | 1999-12-16 | Crum Albert B | Prophylactic and therapeutic nutritional supplement for creation/maintenance of health-protective intestinal microflora and enhancement of the immune system |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1642559A2 (en) * | 2000-07-06 | 2006-04-05 | Beiersdorf AG | Use of creatine and/or creatine derivatives in cosmetic or dermatological preparations |
EP1642559A3 (en) * | 2000-07-06 | 2009-05-06 | Beiersdorf AG | Use of creatine and/or creatine derivatives in cosmetic or dermatological preparations |
US7288570B2 (en) | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
WO2004056208A1 (en) * | 2002-12-20 | 2004-07-08 | Nutricia N.V. | Stimulation of in vivo production of proteins with formulation comprising leucine |
CN100353866C (en) * | 2002-12-20 | 2007-12-12 | 柳垂舍公司 | Stimulation of in vivo production of proteins with formulation comprising leucine |
EP1781334A4 (en) * | 2004-08-25 | 2011-07-06 | Iml Formulations Ltd | Compositions and methods for activating protein synthesis and deactivating catabolic processes in skeletal muscle |
EP1781334A2 (en) * | 2004-08-25 | 2007-05-09 | Mtor Formulations Ltd. | Compositions and methods for activating protein synthesis and deactivating catabolic processes in skeletal muscle |
DE102005028446A1 (en) * | 2005-06-17 | 2006-12-28 | Sibylle E. Bauer | Composition, preferably dietary supplements or dietetic food, useful e.g. to increase the efficiency and well-being of a healthy person, comprises colostrum and at least a ketocarboxylic acid |
WO2007056176A2 (en) * | 2005-11-03 | 2007-05-18 | Southwest Immunology, Inc. | Compositions for preventing and reducing delayed onset muscle soreness |
WO2007056176A3 (en) * | 2005-11-03 | 2007-11-22 | Southwest Immunology Inc | Compositions for preventing and reducing delayed onset muscle soreness |
US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
CN102711525A (en) * | 2010-01-29 | 2012-10-03 | 雅培制药有限公司 | Nutritional emulsions comprising calcium HMB and soluble protein |
US8916217B2 (en) | 2010-01-29 | 2014-12-23 | Abbott Laboratories | Aseptically packaged nutritional liquids comprising HMB |
CN102711525B (en) * | 2010-01-29 | 2015-03-11 | 雅培制药有限公司 | Nutritional emulsions comprising calcium HMB and soluble protein |
US9241508B2 (en) | 2010-01-29 | 2016-01-26 | Abbott Laboratories | Nutritional emulsions comprising calcium HMB |
CN101791127A (en) * | 2010-03-05 | 2010-08-04 | 北京康比特体育科技股份有限公司 | Muscle protection composite containing HMbeta |
US9521859B2 (en) | 2010-06-10 | 2016-12-20 | Normanella T. Dewille | Substantially clear nutritional liquids comprising calcium HMB and soluble protein |
US20190216821A1 (en) * | 2016-02-11 | 2019-07-18 | Nutrition 21, Llc | Chromium Containing Compositions for Improving Health and Fitness |
US11857553B2 (en) * | 2016-02-11 | 2024-01-02 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
US11865121B2 (en) | 2016-02-11 | 2024-01-09 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
Also Published As
Publication number | Publication date |
---|---|
AU3780901A (en) | 2001-08-20 |
DE60140426D1 (en) | 2009-12-24 |
EP1253830A1 (en) | 2002-11-06 |
HK1048050A1 (en) | 2003-03-21 |
CA2398990C (en) | 2013-04-02 |
CA2398990A1 (en) | 2001-08-16 |
AU2001237809B2 (en) | 2005-04-07 |
ES2336764T3 (en) | 2010-04-16 |
US6521591B1 (en) | 2003-02-18 |
EP1253830B1 (en) | 2009-11-11 |
ATE447858T1 (en) | 2009-11-15 |
HK1048050B (en) | 2009-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2398990C (en) | Pharmaceutical composition for muscular anabolism | |
AU2001237809A1 (en) | Pharmaceutical composition for muscular anabolism | |
EP1455603B1 (en) | Stimulation of in vivo production of proteins with formulation comprising leucine | |
US6262019B1 (en) | Method of treatment of glutathione deficient mammals | |
AU784752B2 (en) | Food supplement for increasing lean mass and strength | |
US6903136B2 (en) | Food supplements containing 4-hydroxyisoleucine and creatine | |
US6784209B1 (en) | Food supplement for increasing lean mass and strength | |
US20040023889A1 (en) | Alpha lipoic acid based food supplement for increasing lean muscle mass and strength | |
WO2012005568A1 (en) | Nutritional composition for the stimulation of muscle protein synthesis | |
WO1998049906A1 (en) | Peri-operative drink | |
JP2000516937A (en) | Vitamin preparations that reduce oxygen consumption during exercise |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001910231 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001237809 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2398990 Country of ref document: CA |
|
WWP | Wipo information: published in national office |
Ref document number: 2001910231 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 Ref country code: DE Ref legal event code: 8642 |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2001237809 Country of ref document: AU |