WO2001052897A3 - Therapeutic anti-inflammatory and analgesic composition containing selective cox-2 inhibitors - Google Patents

Therapeutic anti-inflammatory and analgesic composition containing selective cox-2 inhibitors Download PDF

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Publication number
WO2001052897A3
WO2001052897A3 PCT/IN2001/000007 IN0100007W WO0152897A3 WO 2001052897 A3 WO2001052897 A3 WO 2001052897A3 IN 0100007 W IN0100007 W IN 0100007W WO 0152897 A3 WO0152897 A3 WO 0152897A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory
selective cox
therapeutic anti
inhibitors
composition containing
Prior art date
Application number
PCT/IN2001/000007
Other languages
French (fr)
Other versions
WO2001052897A2 (en
Inventor
Amarjit Singh
Rajesh Jain
Original Assignee
Panacea Biotec Ltd
Amarjit Singh
Rajesh Jain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd, Amarjit Singh, Rajesh Jain filed Critical Panacea Biotec Ltd
Priority to AU44515/01A priority Critical patent/AU4451501A/en
Publication of WO2001052897A2 publication Critical patent/WO2001052897A2/en
Publication of WO2001052897A3 publication Critical patent/WO2001052897A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A therapeutic anti-inflammatory and analgesic composition for topical/transdermal use which comprises: Selective Cox-2 inhibitor drugs from 0.1% to 40% w/w and percutaneous absorption enhancing vehicle/base from 60% to 99.9% w/w. Optionally Gelling agent/thickening agent (0% to 60% w/w) surfactant (0% to 20% w/w), Neutralizing agent/pH adjusting agent (0% to 5% w/w) may be added to the said composition.
PCT/IN2001/000007 2000-01-21 2001-01-19 Therapeutic anti-inflammatory and analgesic composition containing selective cox-2 inhibitors WO2001052897A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44515/01A AU4451501A (en) 2000-01-21 2001-01-19 Therapeutic anti-inflammatory and analgesic composition containing selective cox-2 inhibitor drugs for use transdermally and a process for the manufacture thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN46/DEL/2000 2000-01-21
IN46DE2000 IN191512B (en) 2000-01-21 2000-01-21

Publications (2)

Publication Number Publication Date
WO2001052897A2 WO2001052897A2 (en) 2001-07-26
WO2001052897A3 true WO2001052897A3 (en) 2002-03-14

Family

ID=11097023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2001/000007 WO2001052897A2 (en) 2000-01-21 2001-01-19 Therapeutic anti-inflammatory and analgesic composition containing selective cox-2 inhibitors

Country Status (3)

Country Link
AU (1) AU4451501A (en)
IN (1) IN191512B (en)
WO (1) WO2001052897A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035107A1 (en) 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
DE10032132A1 (en) * 2000-07-01 2002-01-17 Lohmann Therapie Syst Lts Dermal therapeutic system containing non-steroidal anti-inflammatory drugs with selective COX-2 inhibition
IN191090B (en) * 2000-08-29 2003-09-20 Ranbanx Lab Ltd
AP2003002922A0 (en) * 2001-05-31 2003-12-31 Pharmacia Corp Skin-permeable selective cyclooxygenase-2 inhibitor composition.
DE10161077A1 (en) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Highly concentrated stable meloxicam solutions for needleless injection
WO2004000263A1 (en) 2002-06-25 2003-12-31 Acrux Dds Pty Ltd Transdermal delivery rate control using amorphous pharmaceutical compositions
UY27984A1 (en) * 2002-09-17 2004-04-30 Nippon Boehringer Ingelheim Co PHARMACEUTICAL COMPOSITION FOR SUPPLY BY MELOXICAM TOPICS
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US20050020658A1 (en) * 2002-11-21 2005-01-27 Katsuyuki Inoo Selective cyclooxygenase-2 inhibitor patch
US20040126415A1 (en) * 2002-11-21 2004-07-01 Lu Guang Wei Dermal delivery of a water-soluble selective cyclooxygenase-2 inhibitor
US20040127531A1 (en) * 2002-11-21 2004-07-01 Lu Guang Wei Adhesive coated sheet for dermal delivery of a selective cyclooxygenase-2 inhibitor
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
RO122835B9 (en) * 2006-12-19 2010-06-30 Ion Fulga Use of diethylamine as an analgesic in pharmaceutical preparations
WO2011046853A1 (en) 2009-10-12 2011-04-21 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
US9149480B2 (en) 2010-03-03 2015-10-06 Boehringer Ingeleheim Vetmedica GmbH Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
EA023000B1 (en) * 2012-10-25 2016-04-29 Закрытое Акционерное Общество "Фармфирма "Сотекс" External medication for treatment of diseases of joints and soft tissues
WO2016015094A1 (en) * 2014-07-31 2016-02-04 Acrux Dds Pty Ltd Topical composition
CA2987388A1 (en) * 2015-05-29 2016-12-08 Kiel Laboratories, Inc. Liquid formulations of celecoxib for oral administration
CA3024205A1 (en) * 2016-05-16 2017-11-23 Delivra Inc. Transdermal formulations for delivery of celecoxib and its use in the treatment of celecoxib-responsive diseases and conditions
JP2023510354A (en) * 2020-01-10 2023-03-13 ブリオリ バイオテック，エルエルシー Topical compositions containing rofecoxib and methods of making and using the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147146A2 (en) * 1983-12-22 1985-07-03 American Home Products Corporation Enhancement of transdermal drug delivery
WO1992004019A1 (en) * 1990-09-05 1992-03-19 Beecham Group Plc Topical treatment and composition
WO1996041626A1 (en) * 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
EP0782855A1 (en) * 1994-10-05 1997-07-09 Helsinn Healthcare S.A. Antiinflammatory agent for external use
EP0812587A1 (en) * 1996-05-29 1997-12-17 Panacea Biotec Limited Transdermal compositions containing Nimesulide
WO1999044640A1 (en) * 1998-03-06 1999-09-10 Merck Sharp & Dohme Limited Combination of a selective nmda nr2b antagonist and a cox-2 inhibitor
WO2000000120A1 (en) * 1998-06-29 2000-01-06 Pharmaceuticals Applications Asociates, Llc Methods and transdermal compositions for pain relief

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147146A2 (en) * 1983-12-22 1985-07-03 American Home Products Corporation Enhancement of transdermal drug delivery
WO1992004019A1 (en) * 1990-09-05 1992-03-19 Beecham Group Plc Topical treatment and composition
EP0782855A1 (en) * 1994-10-05 1997-07-09 Helsinn Healthcare S.A. Antiinflammatory agent for external use
WO1996041626A1 (en) * 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
EP0812587A1 (en) * 1996-05-29 1997-12-17 Panacea Biotec Limited Transdermal compositions containing Nimesulide
WO1999044640A1 (en) * 1998-03-06 1999-09-10 Merck Sharp & Dohme Limited Combination of a selective nmda nr2b antagonist and a cox-2 inhibitor
WO2000000120A1 (en) * 1998-06-29 2000-01-06 Pharmaceuticals Applications Asociates, Llc Methods and transdermal compositions for pain relief

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRYER B ET AL: "The advent of highly selective inhibitors of cyclooxygenase-a review - Implications for gastrointestinal toxicity", PROSTAGLANDINS AND OTHER LIPID MEDIATORS, BUTTERWORTH, STONEHAM, MA, US, vol. 56, no. 5-6, August 1998 (1998-08-01), pages 341 - 361, XP004156755, ISSN: 0090-6980 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, SPANGLER R S: "New insight into NSAID-induced gastropathy.", XP002176551, Database accession no. PREV199698736774 *
INFLAMMOPHARMACOLOGY, vol. 3, no. 4, 1995, pages 347 - 350, ISSN: 0925-4692 *

Also Published As

Publication number Publication date
AU4451501A (en) 2001-07-31
IN191512B (en) 2003-12-06
WO2001052897A2 (en) 2001-07-26

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