WO2001052860A3 - Method and composition for modulating an immune response - Google Patents

Method and composition for modulating an immune response Download PDF

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Publication number
WO2001052860A3
WO2001052860A3 PCT/US2001/001678 US0101678W WO0152860A3 WO 2001052860 A3 WO2001052860 A3 WO 2001052860A3 US 0101678 W US0101678 W US 0101678W WO 0152860 A3 WO0152860 A3 WO 0152860A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulating
composition
immune response
inhibitors
antiporter
Prior art date
Application number
PCT/US2001/001678
Other languages
French (fr)
Other versions
WO2001052860A2 (en
Inventor
George Hasko
Csaba Szabo
Original Assignee
Inotek Corp
George Hasko
Csaba Szabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Corp, George Hasko, Csaba Szabo filed Critical Inotek Corp
Priority to AU2001229601A priority Critical patent/AU2001229601A1/en
Publication of WO2001052860A2 publication Critical patent/WO2001052860A2/en
Publication of WO2001052860A3 publication Critical patent/WO2001052860A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is a method of inhibiting or preventing a condition associated with undesired secretion of a macrophage inflammatory protein using inhibitors of ATP-sensitive K+-channels, inhibitors of the Na+/H+ antiporter, or inosine.
PCT/US2001/001678 2000-01-24 2001-01-18 Method and composition for modulating an immune response WO2001052860A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001229601A AU2001229601A1 (en) 2000-01-24 2001-01-18 Method and composition for modulating an immune response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49188800A 2000-01-24 2000-01-24
US09/491,888 2000-01-24

Publications (2)

Publication Number Publication Date
WO2001052860A2 WO2001052860A2 (en) 2001-07-26
WO2001052860A3 true WO2001052860A3 (en) 2002-06-20

Family

ID=23954080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/001678 WO2001052860A2 (en) 2000-01-24 2001-01-18 Method and composition for modulating an immune response

Country Status (2)

Country Link
AU (1) AU2001229601A1 (en)
WO (1) WO2001052860A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2043650A2 (en) 2006-07-14 2009-04-08 Medical Research Council Treatment for demyelinating disease

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260275A (en) * 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
EP0688766A1 (en) * 1994-06-20 1995-12-27 Hoechst Aktiengesellschaft Phenylsubstituted alkenyl-carboxylic-acid-guanidines containing perfluoroalkyl groups, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them
WO1996009823A1 (en) * 1994-09-28 1996-04-04 Shaman Pharmaceuticals, Inc. Hypoglycemic agent from cryptolepis
EP0749751A2 (en) * 1995-06-20 1996-12-27 Takeda Chemical Industries, Ltd. Pharmaceutical composition for use in tteatment of diabetes
WO1997017975A1 (en) * 1995-11-14 1997-05-22 Abiogen Pharma S.R.L. A glibenclamide-metformin combination for the treatment of diabetes mellitus of type ii
WO1998056378A1 (en) * 1997-06-13 1998-12-17 Novo Nordisk A/S Novel niddm regimen
WO1999018932A1 (en) * 1997-10-15 1999-04-22 Edward Mendell Co., Inc. Novel once-a-day controlled release sulfonylurea formulation
WO1999037151A1 (en) * 1998-01-23 1999-07-29 Board Of Regents, The University Of Texas System Method and compositions for promotion of wound healing

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260275A (en) * 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
EP0688766A1 (en) * 1994-06-20 1995-12-27 Hoechst Aktiengesellschaft Phenylsubstituted alkenyl-carboxylic-acid-guanidines containing perfluoroalkyl groups, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them
WO1996009823A1 (en) * 1994-09-28 1996-04-04 Shaman Pharmaceuticals, Inc. Hypoglycemic agent from cryptolepis
EP0749751A2 (en) * 1995-06-20 1996-12-27 Takeda Chemical Industries, Ltd. Pharmaceutical composition for use in tteatment of diabetes
WO1997017975A1 (en) * 1995-11-14 1997-05-22 Abiogen Pharma S.R.L. A glibenclamide-metformin combination for the treatment of diabetes mellitus of type ii
WO1998056378A1 (en) * 1997-06-13 1998-12-17 Novo Nordisk A/S Novel niddm regimen
WO1999018932A1 (en) * 1997-10-15 1999-04-22 Edward Mendell Co., Inc. Novel once-a-day controlled release sulfonylurea formulation
WO1999037151A1 (en) * 1998-01-23 1999-07-29 Board Of Regents, The University Of Texas System Method and compositions for promotion of wound healing

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUNNING B E: "NATEGLINIDE: A GLUCOSE-SENSITIVE INSULINOTROPIC AGENT THAT IS CHEMICALLY AND PHARMACOLOGICALLY DISTINCT FROM THE SULFONYLUREAS", CURRENT OPINION IN ENDOCRINOLOGYAND DIABETES, PHILADELPHIA, PA, US, vol. 6, no. SUPPL 1, August 1999 (1999-08-01), pages S29 - S31, XP000997507, ISSN: 1068-3097 *
PERFETTI R ET AL: "NOVEL THERAPEUTIC STRATEGIES FOR THE TREATMENT OF TYPE 2 DIABETES", DIABETES/METABOLISM REVIEWS, WILEY, NEW YORK, NY, US, vol. 14, no. 3, 1998, pages 207 - 225, XP000908775, ISSN: 0742-4221 *

Also Published As

Publication number Publication date
WO2001052860A2 (en) 2001-07-26
AU2001229601A1 (en) 2001-07-31

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