WO2001051657A3 - Susceptibility gene for autoimmune disease - Google Patents

Susceptibility gene for autoimmune disease Download PDF

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Publication number
WO2001051657A3
WO2001051657A3 PCT/GB2001/000112 GB0100112W WO0151657A3 WO 2001051657 A3 WO2001051657 A3 WO 2001051657A3 GB 0100112 W GB0100112 W GB 0100112W WO 0151657 A3 WO0151657 A3 WO 0151657A3
Authority
WO
WIPO (PCT)
Prior art keywords
autoimmune disease
susceptibility gene
human subject
disease
gene
Prior art date
Application number
PCT/GB2001/000112
Other languages
French (fr)
Other versions
WO2001051657A2 (en
Inventor
Penelope Jane Hunt
Sara Elizabeth Farah Marshall
John Irving Bell
Original Assignee
Isis Innovation
Penelope Jane Hunt
Sara Elizabeth Farah Marshall
John Irving Bell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Penelope Jane Hunt, Sara Elizabeth Farah Marshall, John Irving Bell filed Critical Isis Innovation
Priority to EP01900516A priority Critical patent/EP1250454A2/en
Priority to AU2001225342A priority patent/AU2001225342A1/en
Publication of WO2001051657A2 publication Critical patent/WO2001051657A2/en
Publication of WO2001051657A3 publication Critical patent/WO2001051657A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method is described for determining, in a human subject, a predisposition to autoimmune thyroid disease such as autoimmune hypothyroidism or Grave's disease. The method comprises determing the genotype of the human subject at the -590 position of the promoter region of the Il-4 gene.
PCT/GB2001/000112 2000-01-11 2001-01-11 Susceptibility gene for autoimmune disease WO2001051657A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01900516A EP1250454A2 (en) 2000-01-11 2001-01-11 Susceptibility gene for autoimmune disease
AU2001225342A AU2001225342A1 (en) 2000-01-11 2001-01-11 Susceptibility gene for autoimmune disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0000563.7 2000-01-11
GBGB0000563.7A GB0000563D0 (en) 2000-01-11 2000-01-11 Susceptibility gene for autoimmune disease

Publications (2)

Publication Number Publication Date
WO2001051657A2 WO2001051657A2 (en) 2001-07-19
WO2001051657A3 true WO2001051657A3 (en) 2002-07-18

Family

ID=9883499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/000112 WO2001051657A2 (en) 2000-01-11 2001-01-11 Susceptibility gene for autoimmune disease

Country Status (4)

Country Link
EP (1) EP1250454A2 (en)
AU (1) AU2001225342A1 (en)
GB (1) GB0000563D0 (en)
WO (1) WO2001051657A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017051439A1 (en) * 2015-09-21 2017-03-30 UNIVERSITA' DEGLI STUDI Dl MESSINA Haplotypes of d7s 6440 microsatellite internal to the hipk2 gene as markers of autoimmune thyroiditis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HUNT P ET AL: "Cytokin gene polymorphisms in autoimmune thyroid disease", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 85, no. 5, May 2000 (2000-05-01), pages 1984 - 88, XP002195987 *
KANEMITSU S ET AL: "Association of interleukin-4 receptor and interleukin-4 promoter gene polymorphisms with systemic lupus erythematosus", ARTHRITIS AND RHEUMATISM, vol. 42, no. 6, June 1999 (1999-06-01), pages 1298 - 99, XP001064873 *
KAWASHIMA T ET AL: "Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families", JOURNAL OF MEDICAL GENETICS, vol. 35, no. 6, June 1999 (1999-06-01), pages 502 - 4, XP001064877 *
SEDDON B ET AL: "Regulatory T cells in the control of autoimmunity", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 189, no. 2, January 1999 (1999-01-01), pages 279 - 88, XP002195986 *

Also Published As

Publication number Publication date
AU2001225342A1 (en) 2001-07-24
WO2001051657A2 (en) 2001-07-19
GB0000563D0 (en) 2000-03-01
EP1250454A2 (en) 2002-10-23

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