WO2001049662A3 - Tricycliques substitues - Google Patents

Tricycliques substitues Download PDF

Info

Publication number
WO2001049662A3
WO2001049662A3 PCT/US2001/010850 US0110850W WO0149662A3 WO 2001049662 A3 WO2001049662 A3 WO 2001049662A3 US 0110850 W US0110850 W US 0110850W WO 0149662 A3 WO0149662 A3 WO 0149662A3
Authority
WO
WIPO (PCT)
Prior art keywords
spla2
inhibitors
carbazole derivatives
compounds
class
Prior art date
Application number
PCT/US2001/010850
Other languages
English (en)
Other versions
WO2001049662A2 (fr
Inventor
Ho-Shen Lin
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Ho-Shen Lin
Michael Enrico Richett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Ho-Shen Lin, Michael Enrico Richett filed Critical Lilly Co Eli
Priority to EP01918984A priority Critical patent/EP1248769A2/fr
Priority to AU45996/01A priority patent/AU4599601A/en
Publication of WO2001049662A2 publication Critical patent/WO2001049662A2/fr
Publication of WO2001049662A3 publication Critical patent/WO2001049662A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle classe de composés indoles, et l'utilisation de ces composés pour inhiber la libération d'acides gras associée à la sPLA2 afin de traiter des maladies inflammatoires telles que le choc sceptique.
PCT/US2001/010850 2000-01-07 2001-01-05 Tricycliques substitues WO2001049662A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01918984A EP1248769A2 (fr) 2000-01-07 2001-01-05 Derives de carbazole en tant qu'inhibiteurs de spla2
AU45996/01A AU4599601A (en) 2000-01-07 2001-01-05 Substituted tricyclics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17502800P 2000-01-07 2000-01-07
US60/175,028 2000-01-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/168,152 A-371-Of-International US20030096854A1 (en) 2000-01-07 2001-01-05 Substituted tricyclics
US10/830,380 Division US20040204473A1 (en) 2000-01-07 2004-04-22 Substituted tricyclics

Publications (2)

Publication Number Publication Date
WO2001049662A2 WO2001049662A2 (fr) 2001-07-12
WO2001049662A3 true WO2001049662A3 (fr) 2002-06-27

Family

ID=22638535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010850 WO2001049662A2 (fr) 2000-01-07 2001-01-05 Tricycliques substitues

Country Status (3)

Country Link
EP (1) EP1248769A2 (fr)
AU (1) AU4599601A (fr)
WO (1) WO2001049662A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE353876T1 (de) 2001-03-28 2007-03-15 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
EP1678137A1 (fr) * 2003-10-15 2006-07-12 Chiron Corporation Compositions et procedes d inhibition virale

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654326A (en) * 1994-04-01 1997-08-05 Eli Lilly And Company 1H-indole-3-glyoxylamide SPLA2 inhibitors
WO1999025340A1 (fr) * 1997-11-14 1999-05-27 Eli Lilly And Company Traitement contre la maladie d'alzheimer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654326A (en) * 1994-04-01 1997-08-05 Eli Lilly And Company 1H-indole-3-glyoxylamide SPLA2 inhibitors
WO1999025340A1 (fr) * 1997-11-14 1999-05-27 Eli Lilly And Company Traitement contre la maladie d'alzheimer

Also Published As

Publication number Publication date
WO2001049662A2 (fr) 2001-07-12
AU4599601A (en) 2001-07-16
EP1248769A2 (fr) 2002-10-16

Similar Documents

Publication Publication Date Title
EP1081135A3 (fr) 1H-Indole-3-glyoxylamides en tant qu'inhibiteurs de sPLA2
AU5598398A (en) Pyrroles as sPLA2 inhibitors
WO2002050030A3 (fr) Nouveaux inhibiteurs de spla2
EP1100492A4 (fr) INHIBITEURS DE sPLA 2? DE TYPE INDOLE
AU5454498A (en) Phenyl glyoxamides as spla2 inhibitors
WO2002050034A3 (fr) Nouveaux inhibiteurs spla¿2?
AU5873400A (en) spla2 inhibitors
ATE312817T1 (de) Cyclohept'bö indolderivate als spla2-inhibitoren
WO2002012249A3 (fr) Nouveaux inhibiteurs du spla¿2?
AU7053700A (en) Novel spla2 inhibitors
WO2001049662A3 (fr) Tricycliques substitues
WO2002050028A8 (fr) Benzoindoles substitués inhibiteurs des spla¿2?
WO2000037472A3 (fr) Tricycliques substitues
WO2002057231A3 (fr) Nouveaux inhibiteurs spla2
WO2002000641A3 (fr) Nouveaux inhibiteurs de spla2
WO2002050029A8 (fr) Nouveaux inhibiteurs de spla2

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10168152

Country of ref document: US

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001918984

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001918984

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP