WO2001044502A3 - Genetic variants of the human fsh receptor and the influence thereof on gametogenesis - Google Patents

Genetic variants of the human fsh receptor and the influence thereof on gametogenesis Download PDF

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Publication number
WO2001044502A3
WO2001044502A3 PCT/EP2000/012886 EP0012886W WO0144502A3 WO 2001044502 A3 WO2001044502 A3 WO 2001044502A3 EP 0012886 W EP0012886 W EP 0012886W WO 0144502 A3 WO0144502 A3 WO 0144502A3
Authority
WO
WIPO (PCT)
Prior art keywords
fsh receptor
gametogenesis
influence
genetic variants
human fsh
Prior art date
Application number
PCT/EP2000/012886
Other languages
French (fr)
Other versions
WO2001044502A2 (en
Inventor
Joerg Gromoll
Manuela Simoni
Eberhard Nieschlag
M Hermann Behre
Maritza Perez
Original Assignee
Joerg Gromoll
Manuela Simoni
Eberhard Nieschlag
M Hermann Behre
Maritza Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99125148A external-priority patent/EP1108791A1/en
Application filed by Joerg Gromoll, Manuela Simoni, Eberhard Nieschlag, M Hermann Behre, Maritza Perez filed Critical Joerg Gromoll
Priority to JP2001545579A priority Critical patent/JP2003516761A/en
Priority to AU31601/01A priority patent/AU3160101A/en
Priority to CA002363100A priority patent/CA2363100A1/en
Publication of WO2001044502A2 publication Critical patent/WO2001044502A2/en
Publication of WO2001044502A3 publication Critical patent/WO2001044502A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Abstract

The present invention provides a method for determining the dosage of FSH in the treatment of infertility of women comprising the determination of the FSH receptor variant of the soman to be treated, a method for treating infertility in women which comprises said determination of the FSH receptor variant and a kit for performing said determination of the FSH receptor variant.
PCT/EP2000/012886 1999-12-16 2000-12-18 Genetic variants of the human fsh receptor and the influence thereof on gametogenesis WO2001044502A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001545579A JP2003516761A (en) 1999-12-16 2000-12-18 Genetic variants of the human FSH receptor and their effects on gametogenesis
AU31601/01A AU3160101A (en) 1999-12-16 2000-12-18 Genetic variants of the human FSH receptor and the influence thereof on gametogenesis
CA002363100A CA2363100A1 (en) 1999-12-16 2000-12-18 Genetic variants of the human fsh receptor and the influence thereof on gametogenesis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99125148.9 1999-12-16
EP99125148A EP1108791A1 (en) 1999-12-16 1999-12-16 Genetic variants of the human FSH receptor and the influence thereof on gametogenesis
US18567000P 2000-02-29 2000-02-29
US60/185,670 2000-02-29

Publications (2)

Publication Number Publication Date
WO2001044502A2 WO2001044502A2 (en) 2001-06-21
WO2001044502A3 true WO2001044502A3 (en) 2002-02-14

Family

ID=26153198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/012886 WO2001044502A2 (en) 1999-12-16 2000-12-18 Genetic variants of the human fsh receptor and the influence thereof on gametogenesis

Country Status (4)

Country Link
JP (1) JP2003516761A (en)
AU (1) AU3160101A (en)
CA (1) CA2363100A1 (en)
WO (1) WO2001044502A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011194A1 (en) * 1995-09-20 1997-03-27 Helsinki University Licensing Ltd. Oy Method for diagnosis of ovarian dysgenesis
WO1998034948A1 (en) * 1997-02-06 1998-08-13 Cornell Research Foundation, Inc. Library screening as a strategy to clone drugs for g protein coupled receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011194A1 (en) * 1995-09-20 1997-03-27 Helsinki University Licensing Ltd. Oy Method for diagnosis of ovarian dysgenesis
WO1998034948A1 (en) * 1997-02-06 1998-08-13 Cornell Research Foundation, Inc. Library screening as a strategy to clone drugs for g protein coupled receptors

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BEN-RAFAEL Z ET AL.: "Pharmacokinetics of follicle-stimulating hormone: clinical significance", FERTILITY AND STERILITY, vol. 69, no. 3Sp2, March 1998 (1998-03-01), pages 40S - 49S, XP001023707 *
CONWAY G.S. ET AL.,: "Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome", CLINICAL ENDOCRINOLOGY, vol. 51, July 1999 (1999-07-01), pages 97 - 99, XP000920627 *
GROMOLL J ET AL: "AN ACTIVATING MUTATION OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR AUTONAMOUSLY SUSTAINS SPERMATOGENESIS IN A HYPOPHYSECTOMIZED MAN", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, NEW YORK, NY, US, vol. 81, no. 4, 1 April 1996 (1996-04-01), pages 1367 - 1370, XP000609740, ISSN: 0021-972X *
HEIKOOP J C ET AL: "Infertility treatment by recombinant FSH", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 3, 13 May 1998 (1998-05-13), pages 233 - 236, XP004128060, ISSN: 0168-1656 *
JIANG M ET AL.: "The frequency of a inactivating point mutation (566C-T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 83, no. 12, 1998, pages 4338 - 4343, XP001023798 *
LAYMAN L C ET AL.: "The Finnish follicle-stimulating hormone receptor gene mutation is rare in North American women with 46,XX ovarian failure", FERTILITY AND STERILITY, vol. 69, no. 2, 1998, pages 300 - 302, XP001023705 *
SIMONI M. ET AL.: "Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms", JOURNAL OF CLIN. ENDOCRINOLOGY AND METABOLISM, vol. 84, no. 2, - February 1999 (1999-02-01), pages 751 - 755, XP000920695 *

Also Published As

Publication number Publication date
AU3160101A (en) 2001-06-25
WO2001044502A2 (en) 2001-06-21
CA2363100A1 (en) 2001-06-21
JP2003516761A (en) 2003-05-20

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