WO2001044444A3 - A protein kinase (ikk4) involved in the phosphorylation of ikb - Google Patents

A protein kinase (ikk4) involved in the phosphorylation of ikb Download PDF

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Publication number
WO2001044444A3
WO2001044444A3 PCT/JP2000/008873 JP0008873W WO0144444A3 WO 2001044444 A3 WO2001044444 A3 WO 2001044444A3 JP 0008873 W JP0008873 W JP 0008873W WO 0144444 A3 WO0144444 A3 WO 0144444A3
Authority
WO
WIPO (PCT)
Prior art keywords
ikk4
ikb
phosphorylation
involved
protein kinase
Prior art date
Application number
PCT/JP2000/008873
Other languages
French (fr)
Other versions
WO2001044444A2 (en
Inventor
Yasuhiro Hashimoto
Yoshihiro Takemoto
Masaaki Furuta
Yutaka Sakai
Original Assignee
Glaxo Wellcome Kabushiki Kaish
Yasuhiro Hashimoto
Yoshihiro Takemoto
Masaaki Furuta
Yutaka Sakai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Kabushiki Kaish, Yasuhiro Hashimoto, Yoshihiro Takemoto, Masaaki Furuta, Yutaka Sakai filed Critical Glaxo Wellcome Kabushiki Kaish
Priority to AU18901/01A priority Critical patent/AU1890101A/en
Publication of WO2001044444A2 publication Critical patent/WO2001044444A2/en
Publication of WO2001044444A3 publication Critical patent/WO2001044444A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel inhibitory kappa B kinase (IKK) is disclosed herein as IKK4. Polynucleotides encoding IKK4, expression vectors comprising said polynucleotides and screening methods for identifying therapeutic modulators of IKK4 activity are also disclosed.
PCT/JP2000/008873 1999-12-14 2000-12-14 A protein kinase (ikk4) involved in the phosphorylation of ikb WO2001044444A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18901/01A AU1890101A (en) 1999-12-14 2000-12-14 Ikk4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929542.0A GB9929542D0 (en) 1999-12-14 1999-12-14 Ikk4
GB9929542.0 1999-12-14

Publications (2)

Publication Number Publication Date
WO2001044444A2 WO2001044444A2 (en) 2001-06-21
WO2001044444A3 true WO2001044444A3 (en) 2002-05-10

Family

ID=10866294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/008873 WO2001044444A2 (en) 1999-12-14 2000-12-14 A protein kinase (ikk4) involved in the phosphorylation of ikb

Country Status (3)

Country Link
AU (1) AU1890101A (en)
GB (1) GB9929542D0 (en)
WO (1) WO2001044444A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005035746A2 (en) * 2003-10-02 2005-04-21 Xantos Biomedicine Ag Medical use of tbk-1 or of inhibitors thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039410A1 (en) * 1997-03-07 1998-09-11 Tularik Inc. IλB $i(KINASES)
WO1999058558A2 (en) * 1998-05-13 1999-11-18 Incyte Pharmaceuticals, Inc. Cell signaling proteins
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039410A1 (en) * 1997-03-07 1998-09-11 Tularik Inc. IλB $i(KINASES)
WO1999058558A2 (en) * 1998-05-13 1999-11-18 Incyte Pharmaceuticals, Inc. Cell signaling proteins
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 11 May 2000 (2000-05-11), TOJIMA Y. ET AL.: "Homo sapiens NF-kB-activating kinase NAKmRNA, complete cds.", XP002166489 *
DATABASE EMBL 4 November 1999 (1999-11-04), POMERANTZ JL AND BALTIMORE D: "Homo sapiens TANK binding kinase TBK1 (TBK1) mRNA, complete cds.", XP002166487 *
DATABASE EMBL 6 October 1999 (1999-10-06), CAO Z.: "IkB kinases", XP002166488 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. IV. THE CODING SEQUENCES OF 40 NEW GENES (KIAA0121-KIAA0160) DEDUCED BY ANALYSIS OF CDNA CLONES FROM HUMAN CELL LINE KG-1", DNA RESEARCH,JP,UNIVERSAL ACADEMY PRESS, vol. 2, no. 4, 31 August 1995 (1995-08-31), pages 167 - 174, XP000676653, ISSN: 1340-2838 *
POMERANTZ JL AND BALTIMORE D: "NF-kB activation by signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.", EMBO J., vol. 18, no. 23, 1 December 1999 (1999-12-01), pages 6694 - 6704, XP002166022 *
SHIMADA T ET AL: "IKK-I, A NOVEL LIPOPOLYSACCHARIDE-INDUCIBLE KINASE THAT IS RELATED TO IKB KINASES", INTERNATIONAL IMMUNOLOGY,GB,OXFORD UNIVERSITY PRESS, vol. 11, no. 8, August 1999 (1999-08-01), pages 1357 - 1362, XP000909004, ISSN: 0953-8178 *
TOJIMA Y. ET AL.: "NAK is an IkB kinase-activating kinase", NATURE, vol. 404, 13 April 2000 (2000-04-13), London, pages 778 - 782, XP000996194 *

Also Published As

Publication number Publication date
WO2001044444A2 (en) 2001-06-21
AU1890101A (en) 2001-06-25
GB9929542D0 (en) 2000-02-09

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