WO2001044228A3 - Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses - Google Patents

Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses Download PDF

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Publication number
WO2001044228A3
WO2001044228A3 PCT/FR2000/003534 FR0003534W WO0144228A3 WO 2001044228 A3 WO2001044228 A3 WO 2001044228A3 FR 0003534 W FR0003534 W FR 0003534W WO 0144228 A3 WO0144228 A3 WO 0144228A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
therapeutic uses
derivatives
quinazolinedione
phthalimide
Prior art date
Application number
PCT/FR2000/003534
Other languages
French (fr)
Other versions
WO2001044228A2 (en
Inventor
Michel Aletru
Philippe R Bovy
Claudie Namane
Original Assignee
Sanofi Synthelabo
Michel Aletru
Philippe R Bovy
Claudie Namane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo, Michel Aletru, Philippe R Bovy, Claudie Namane filed Critical Sanofi Synthelabo
Priority to AU25257/01A priority Critical patent/AU2525701A/en
Publication of WO2001044228A2 publication Critical patent/WO2001044228A2/en
Publication of WO2001044228A3 publication Critical patent/WO2001044228A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

The invention relates to a compound of general formula (I), wherein R1 represents a C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, hydroxy-C1-6 alkyl or C1-3alkoxy-C1-6 alkyl group, R2 represents a NR8R9, -O-C1-6 alkylene-NR4R5, -O-C1-6alkylene-CONR4R5 or -O-C1-6 alkylene-CO2R6 group or a group of formula (a), R3 represents a hydrogen atom, a hydroxy, a halogen atom, a cyano, a nitro, an amino or a C1-3 alkyl group, and W represents a C1-3 alkylene or C2-3 alkenylene group; and to their salts and hydrates. The invention also relates to the therapeutic uses of the inventive derivatives.
PCT/FR2000/003534 1999-12-14 2000-12-14 Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses WO2001044228A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25257/01A AU2525701A (en) 1999-12-14 2000-12-14 Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/15717 1999-12-14
FR9915717 1999-12-14

Publications (2)

Publication Number Publication Date
WO2001044228A2 WO2001044228A2 (en) 2001-06-21
WO2001044228A3 true WO2001044228A3 (en) 2001-12-13

Family

ID=9553209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003534 WO2001044228A2 (en) 1999-12-14 2000-12-14 Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses

Country Status (2)

Country Link
AU (1) AU2525701A (en)
WO (1) WO2001044228A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851449B2 (en) 2013-07-03 2023-12-26 Takeda Pharmaceutical Company Limited Heterocyclic amide compounds having an RORvt inhibitory action

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014761A1 (en) * 1997-10-28 2004-01-22 Place Virgil A. Treatment of female sexual dysfunction with phosphodiesterase inhibitors
WO2002089800A2 (en) * 2001-05-05 2002-11-14 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
EP1708713B1 (en) 2004-01-16 2008-03-12 F. Hoffmann-la Roche AG 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1h-quinazolin-2-one derivatives and the respective 1h-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(d)(1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-ht) for the treatment of diseases of the central nervous system
FR2944282B1 (en) * 2009-04-09 2013-05-03 Sanofi Aventis QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR VARIOUS THERAPEUTIC APPLICATIONS
FR2944206B1 (en) 2009-04-09 2012-12-28 Sanofi Aventis THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES
JP6280912B2 (en) * 2013-03-14 2018-02-14 武田薬品工業株式会社 Heterocyclic compounds
JP6427491B2 (en) 2013-07-03 2018-11-21 武田薬品工業株式会社 Heterocyclic compounds
CA2961033A1 (en) 2014-09-11 2016-03-17 Takeda Pharmaceutical Company Limited Heterocyclic compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019342A1 (en) * 1993-02-18 1994-09-01 Kyowa Hakko Kogyo Co., Ltd. Adenosine incorporation inhibitor
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
FR2784379A1 (en) * 1998-10-07 2000-04-14 Synthelabo QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019342A1 (en) * 1993-02-18 1994-09-01 Kyowa Hakko Kogyo Co., Ltd. Adenosine incorporation inhibitor
EP0638567A1 (en) * 1993-02-18 1995-02-15 Kyowa Hakko Kogyo Kabushiki Kaisha Adenosine incorporation inhibitor
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
FR2784379A1 (en) * 1998-10-07 2000-04-14 Synthelabo QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y.EGUCHI ET AL.: "studies on hypotensive agents.", CHEMICAL AND PHARMACEUTICAL BULLETIN., vol. 39, no. 7, 1991, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO., JP, pages 1753 - 9, XP002105928, ISSN: 0009-2363 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851449B2 (en) 2013-07-03 2023-12-26 Takeda Pharmaceutical Company Limited Heterocyclic amide compounds having an RORvt inhibitory action

Also Published As

Publication number Publication date
AU2525701A (en) 2001-06-25
WO2001044228A2 (en) 2001-06-21

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