WO2001043805A2 - Exspirationsabhängige gasdosierung - Google Patents
Exspirationsabhängige gasdosierung Download PDFInfo
- Publication number
- WO2001043805A2 WO2001043805A2 PCT/EP2000/012244 EP0012244W WO0143805A2 WO 2001043805 A2 WO2001043805 A2 WO 2001043805A2 EP 0012244 W EP0012244 W EP 0012244W WO 0143805 A2 WO0143805 A2 WO 0143805A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gas
- supply system
- gas supply
- metering
- expiration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Definitions
- the invention relates to a gas supply system with a controlled metering of at least one gas or at least one aerosol, its use and a method for gas metering in the supply of humans or mammals with one or more gases for inhalation treatment.
- Ventilation devices are used for mechanical ventilation, for anesthesia and for respiratory therapy by treatment with gases, e.g. B. Oxygen donation or treatment with nitrogen monoxide (NO).
- gases e.g. B. Oxygen donation or treatment with nitrogen monoxide (NO).
- a normally portable oxygen dispenser Such patients are referred to as spontaneously breathing patients, in contrast to patients who are intubated to a ventilator in the clinic.
- LOT long-term oxygen therapy
- CPAP continuous positive airways pressure
- the gases are administered either via a so-called nasal cannula or nasal tube (nasal application; in the simplest case, a gas supply hose, the opening of which is open below the patient's nostrils) or via a breathing mask (especially with CPAP).
- WO 98/31282 (internal designation TMG 2028/67) describes a gas supply system for ventilated or spontaneously breathing patients, in which one or more gases (e.g. NO, oxygen) by means of a controller (program control, sensor control or combined program
- the maximum of the inspiratory flow is important, since the metered gas should usually be available at this point in time. This maximum usually coincides with the trigger start point. Due to mechanical, electrical and, above all, flow delays, it is not possible to equate the beginning of the gas flow actually dosed into the nasal / pharynx with the maximum inspiratory flow.
- the dead space volume in particular plays a major role.
- the anatomical dead space includes nasopharynx, trachea, bronchi and bronchioles. In adults, this dead space volume is between 150 and 200 ml.
- part of the respiratory gas entering the alveoli is not used due to a lower perfusion of the alveoli in question.
- This dead space is called the alveolar dead space. This value can vary greatly from patient to patient. COPD patients usually have a higher respiratory rate, but a smaller tidal volume. If you calculate with a tidal volume of 400 ml and a dead space volume of 200 ml, the dead space volume makes up 50% of the tidal volume. As a result, the therapeutic effect is severely affected.
- the gas should therefore be supplied in such a way that the entire amount available at the site of action, the alveolar area, is available.
- the invention has for its object to optimize the gas dosage in inhalation therapy, especially in spontaneous breathing.
- the expiration-triggered gas supply system is a gas supply system for ventilated or spontaneously breathing patients as described in WO 98/31282 (internal name TMG 2028/67) and to which reference is hereby made.
- the gas supply system described in WO 98/31282 is advantageously modified, as will be explained in the following.
- the gas supply system is used in humans and animals, especially mammals.
- the therapeutic gas e.g. 0 2 , NO
- the therapeutic gas must be supplied in such a way that it does not remain in the dead space, ie it must in any case participate in gas exchange or improve it, in which a bolus is as highly concentrated as possible at the site of action reached.
- the therapy gas is delivered to the patient at a defined point in time before inspiration begins to ensure that the gas in question actually reaches the areas of the lungs it is intended to reach. To do this, it is necessary to know the course of the expiration in order to precisely define the starting point of the dosage. This is especially done by measuring the pressure curve during a breathing cycle (expiration and inspiration), e.g. B. in the nasal cannula, usually by means of a pressure sensor or flow sensor (or systems based thereon).
- the pressure curve is characteristic of every patient. Since this pressure curve is relatively the same during each breathing cycle, it can be seen from an instantaneous expiratory pressure when the patient will inhale. Ie it can over a threshold value of the corresponding pressure value Be predicted when the inspiration begins.
- the expiration curve is therefore recorded for each patient, and with the help of an algorithm, each pressure value (depending on whether the curve rises or falls) is assigned a specific point in time before inhalation. By recording this curve in a patient-specific manner by the doctor, each time of the expiration is precisely defined by the pressure curve.
- the trigger pulse is therefore not triggered by the negative pressure created when inhaling, but by an adjustable positive pressure threshold value resulting from the course of the expiration.
- the triggering adapts to the patient's needs due to the possibly fluctuating expiration process, since triggering is not carried out with a time constant, but with the patient-dependent overpressure in the expiration phase.
- This enables automatic adjustment of the triggering depending on the patient's breathing curve.
- the triggering adapts itself automatically to the changed conditions when the patient is subjected to additional stress, which also leads to a change in the breathing curve. This makes it possible to control the metering of one or more therapeutic gases in such a way that various lung areas are targeted by the therapeutic gas due to the individual physiology of the patient.
- This process can be used for all gases that are beneficial for the therapy of lung diseases.
- patients who were previously dependent on a continuous 0 2 supply due to their clinical picture can use this system to receive a pulsed dose, which is associated with a low rem 0 2 consumption, the blood gas values are in the same range as for the continuous gas supply.
- Another application of the method is e.g. B. gas or aerosol therapy in the nasopharynx or in the trachea. This means that the effective area is not directly in the lungs but in the anatomical dead space.
- Fig. 1 illustrates the effect of expiration-triggered gas metering, a gas surge (bolus) of the metered gas to the site of action, e.g. B. in the patient's lungs.
- FIG. 2 schematically shows an expiration curve recorded on the patient before or during the gas treatment, in which the pressure p (in front of the nose or in a breathing mask) recorded in p (in mbar) as a function of the time t (in Seconds, s).
- the mark a represents the point in time at which a fixed threshold value of the pressure p is reached and the mark b represents the point in time when the inspiration begins.
- FIG. 3 to 5 schematically show the volume flow V (in l / min.) Of metered gas (e.g. oxygen) as a function of the time t (in seconds, s) for different metering intervals.
- metered gas e.g. oxygen
- the gas metering shown in FIG. 3 begins at time a during expiration and ends after the start of inspiration, time b, during inspiration.
- the gas dosing shown in FIG. 4 begins at time a during expiration and ends before the start of inspiration, before time b.
- Fig. 5 shows the dosage of two
- Gases the types of gas metering shown in FIGS. 4 and 3 being combined.
- 6 shows a diagram of a gas supply system.
- the gas supply system is designed for the metering of two gases (Gas 1 and Gas 2), which are provided in D-pressure gas containers, for example.
- the gas is metered via the controllable solenoid valves (MV1 and MV2) connected to a control unit (CPU) into a gas line leading to the patient.
- a pressure sensor (labeled ⁇ p) for overpressure and underpressure is in the gas line or e.g. B. at the exit of the gas line (z. B. in front of the patient's nose).
- FIG. 1 shows how any place in the respiratory organs can be specifically treated by means of a defined relationship between gas flow, dosing time and the corresponding starting point of the dosing during expiration.
- Short gas dosing surges (bolus) in particular allow higher concentrations to be achieved at the site of action without affecting other areas. As a result, gas consumption can be reduced, which in turn leads to smaller and therefore lighter storage containers, and any side effects of therapy can be minimized. Due to the short time of the dosing there is no homogenization of the gas mixture and the dosing surge propagates to the desired effective range (Fig. 1).
- FIG. 2 An example of an expiration curve as the basis for triggering and controlling a dosing process is shown in FIG. 2. If the expiratory pressure P reaches the specified threshold value of 1.2 mbar or falls during ventilation, the dosage (in the example corresponds to) this triggered a time of 120 ms before the start of inspiration), whereby all possible forms of metering (see FIGS. 3, 4, 5) can take place.
- the anatomical dead space can be flowed to in a targeted manner. It can target z.
- the dosage can be done either through nasal cannula or through a breathing mask.
- the pressure curve is advantageously recorded by the same pressure sensor which is also responsible for triggering the trigger signal (FIG. 6).
- Dosage of gas or aerosol can either continue only during the expiration (therapy in the anatomical dead space) or also continue during the inspiration (FIGS. 3, 4). Furthermore, several gases can also be metered (FIG. 5), the starting point of the metering (mark a in FIGS. 3 to 5) not necessarily having to be the same.
- the dosing quantities and dosing times depend strongly on the respective therapy and can be varied as desired.
- the starting point of the dosage, the duration of the dosage and the dosage amount vary depending on the areas of the lung that are to be flown to.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00991584A EP1239910B1 (de) | 1999-12-15 | 2000-12-06 | Exspirationsabhängige gasdosierung |
DE50012332T DE50012332D1 (de) | 1999-12-15 | 2000-12-06 | Exspirationsabhängige gasdosierung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19960404A DE19960404A1 (de) | 1999-12-15 | 1999-12-15 | Exspirationsabhängige Gasdosierung |
DE19960404.5 | 1999-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001043805A2 true WO2001043805A2 (de) | 2001-06-21 |
WO2001043805A3 WO2001043805A3 (de) | 2002-01-03 |
Family
ID=7932701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/012244 WO2001043805A2 (de) | 1999-12-15 | 2000-12-06 | Exspirationsabhängige gasdosierung |
Country Status (5)
Country | Link |
---|---|
US (1) | US20030145853A1 (de) |
EP (1) | EP1239910B1 (de) |
AT (1) | ATE318630T1 (de) |
DE (2) | DE19960404A1 (de) |
WO (1) | WO2001043805A2 (de) |
Cited By (2)
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US8557300B2 (en) | 2005-05-19 | 2013-10-15 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
US9675637B2 (en) | 2003-07-09 | 2017-06-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
Families Citing this family (34)
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DE10107443A1 (de) * | 2001-02-16 | 2002-08-29 | Heptec Gmbh | Verfahren zur Desinfektion von Frischluft, Luftdesinfektionsmodul sowie Blitzlampen |
DE10337138A1 (de) * | 2003-08-11 | 2005-03-17 | Freitag, Lutz, Dr. | Verfahren und Anordnung zur Atmungsunterstützung eines Patienten sowie Luftröhrenprothese und Katheter |
US7588033B2 (en) | 2003-06-18 | 2009-09-15 | Breathe Technologies, Inc. | Methods, systems and devices for improving ventilation in a lung area |
US7406966B2 (en) | 2003-08-18 | 2008-08-05 | Menlo Lifesciences, Llc | Method and device for non-invasive ventilation with nasal interface |
US7380550B2 (en) | 2004-01-30 | 2008-06-03 | Hewlett-Packard Development Company, L.P. | Systems and methods for particle detection |
US7819115B2 (en) * | 2004-01-30 | 2010-10-26 | Hewlett-Packard Development Company, L.P. | Inhalers and methods of controlling airflow in inhalers |
ITMI20050491A1 (it) * | 2005-03-24 | 2006-09-25 | Paolo Licciulli | Apparato per la somministrazione di prodotti farmaceutici in forma di aerosol |
JP2009508645A (ja) | 2005-09-20 | 2009-03-05 | ルッツ フレイテッグ, | 患者の呼吸を補助するためのシステム、方法、および装置 |
JP5191005B2 (ja) | 2006-05-18 | 2013-04-24 | ブリーズ テクノロジーズ, インコーポレイテッド | 気管切開の方法およびデバイス |
WO2008019102A2 (en) | 2006-08-03 | 2008-02-14 | Breathe Technologies, Inc. | Methods and devices for minimally invasive respiratory support |
WO2008144589A1 (en) | 2007-05-18 | 2008-11-27 | Breathe Technologies, Inc. | Methods and devices for sensing respiration and providing ventilation therapy |
WO2009042973A1 (en) | 2007-09-26 | 2009-04-02 | Breathe Technologies, Inc. | Methods and devices for treating sleep apnea |
CN101873875B (zh) | 2007-09-26 | 2014-11-12 | 呼吸科技公司 | 用于在通气治疗中提供吸气和呼气流释放的方法和装置 |
EP2237788A4 (de) * | 2007-12-27 | 2013-06-05 | Aires Pharmaceuticals Inc | Aerosolisierte nitrit- und stickoxidspendende verbindungen und ihre verwendung |
JP5758799B2 (ja) | 2008-04-18 | 2015-08-05 | ブリーズ・テクノロジーズ・インコーポレーテッド | 呼吸作用を感知し、人工呼吸器の機能を制御するための方法およびデバイス |
EP2274036A4 (de) | 2008-04-18 | 2014-08-13 | Breathe Technologies Inc | Verfahren und vorrichtungen zur messung von atmung und zur kontrolle der funktionen eines beatmungsgeräts |
WO2009149353A1 (en) | 2008-06-06 | 2009-12-10 | Nellcor Puritan Bennett Llc | Systems and methods for triggering and cycling a ventilator based on reconstructed patient effort signal |
EP2326376B1 (de) | 2008-08-22 | 2019-07-24 | Breathe Technologies, Inc. | Vorrichtungen für mechanische beatmung mit offener atemwegsschnittstelle |
US10252020B2 (en) | 2008-10-01 | 2019-04-09 | Breathe Technologies, Inc. | Ventilator with biofeedback monitoring and control for improving patient activity and health |
US9132250B2 (en) | 2009-09-03 | 2015-09-15 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature |
US9962512B2 (en) | 2009-04-02 | 2018-05-08 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with a free space nozzle feature |
JP5758875B2 (ja) | 2009-04-02 | 2015-08-05 | ブリーズ・テクノロジーズ・インコーポレーテッド | 非侵襲性換気システム |
CN102762250B (zh) | 2009-09-03 | 2017-09-26 | 呼吸科技公司 | 用于包括具有夹带端口和/或压力特征的非密封通气界面的无创通气的方法、系统和装置 |
CA2807416C (en) | 2010-08-16 | 2019-02-19 | Breathe Technologies, Inc. | Methods, systems and devices using lox to provide ventilatory support |
JP6297329B2 (ja) | 2010-09-30 | 2018-03-20 | ブリーズ・テクノロジーズ・インコーポレーテッド | 鼻インタフェース装置 |
US8783250B2 (en) | 2011-02-27 | 2014-07-22 | Covidien Lp | Methods and systems for transitory ventilation support |
US8714154B2 (en) | 2011-03-30 | 2014-05-06 | Covidien Lp | Systems and methods for automatic adjustment of ventilator settings |
US10362967B2 (en) | 2012-07-09 | 2019-07-30 | Covidien Lp | Systems and methods for missed breath detection and indication |
US9808591B2 (en) | 2014-08-15 | 2017-11-07 | Covidien Lp | Methods and systems for breath delivery synchronization |
US9950129B2 (en) | 2014-10-27 | 2018-04-24 | Covidien Lp | Ventilation triggering using change-point detection |
US10792449B2 (en) | 2017-10-03 | 2020-10-06 | Breathe Technologies, Inc. | Patient interface with integrated jet pump |
EP3793656A1 (de) | 2018-05-14 | 2021-03-24 | Covidien LP | Systeme und verfahren zur erfassung der atemleistung unter verwendung von signalverzerrung |
US11717634B2 (en) | 2018-10-02 | 2023-08-08 | MaxxO2, LLC | Therapeutic oxygen breathing apparatus and exercise system |
US11752287B2 (en) | 2018-10-03 | 2023-09-12 | Covidien Lp | Systems and methods for automatic cycling or cycling detection |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998031282A1 (de) | 1997-01-17 | 1998-07-23 | Messer Griesheim Austria Ges.Mbh | Gesteuertes gasversorgungssystem |
Family Cites Families (7)
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US5803066A (en) * | 1992-05-07 | 1998-09-08 | New York University | Method and apparatus for optimizing the continuous positive airway pressure for treating obstructive sleep apnea |
GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
US5479920A (en) * | 1994-03-01 | 1996-01-02 | Vortran Medical Technology, Inc. | Breath actuated medicinal aerosol delivery apparatus |
US5615669A (en) * | 1994-07-22 | 1997-04-01 | Siemens Elema Ab | Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject |
SE9601719D0 (sv) * | 1996-05-06 | 1996-05-06 | Siemens Elema Ab | Doserare för tillförsel av tillsatsgas eller vätska till andningsgas vid anestesiapparat eller ventilator |
US6142147A (en) * | 1998-03-31 | 2000-11-07 | The General Hospital Corporation | Nasal delivery system for inhaled nitric oxide |
SE9803685D0 (sv) * | 1998-10-27 | 1998-10-27 | Siemens Elema Ab | Device for flushing a deadspace in mechanical ventilation |
-
1999
- 1999-12-15 DE DE19960404A patent/DE19960404A1/de not_active Withdrawn
-
2000
- 2000-12-06 DE DE50012332T patent/DE50012332D1/de not_active Expired - Fee Related
- 2000-12-06 EP EP00991584A patent/EP1239910B1/de not_active Expired - Lifetime
- 2000-12-06 US US10/149,615 patent/US20030145853A1/en not_active Abandoned
- 2000-12-06 WO PCT/EP2000/012244 patent/WO2001043805A2/de active IP Right Grant
- 2000-12-06 AT AT00991584T patent/ATE318630T1/de not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998031282A1 (de) | 1997-01-17 | 1998-07-23 | Messer Griesheim Austria Ges.Mbh | Gesteuertes gasversorgungssystem |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9675637B2 (en) | 2003-07-09 | 2017-06-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
US9700578B2 (en) | 2003-07-09 | 2017-07-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
US8557300B2 (en) | 2005-05-19 | 2013-10-15 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
Also Published As
Publication number | Publication date |
---|---|
WO2001043805A3 (de) | 2002-01-03 |
EP1239910A2 (de) | 2002-09-18 |
EP1239910B1 (de) | 2006-03-01 |
DE50012332D1 (de) | 2006-04-27 |
US20030145853A1 (en) | 2003-08-07 |
ATE318630T1 (de) | 2006-03-15 |
DE19960404A1 (de) | 2001-07-05 |
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