WO2001042472A3 - DNA ENCODING A NOVEL PROST-Ets POLYPEPTIDE - Google Patents

DNA ENCODING A NOVEL PROST-Ets POLYPEPTIDE Download PDF

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Publication number
WO2001042472A3
WO2001042472A3 PCT/US2000/042295 US0042295W WO0142472A3 WO 2001042472 A3 WO2001042472 A3 WO 2001042472A3 US 0042295 W US0042295 W US 0042295W WO 0142472 A3 WO0142472 A3 WO 0142472A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
prost
ets
novel
polypeptide
Prior art date
Application number
PCT/US2000/042295
Other languages
French (fr)
Other versions
WO2001042472A2 (en
Inventor
Richard Harkins
Richard J Lin
May Luke
Felipe Monteclaro
Deborah Parkes
Gordon Parry
Renate Steinbrecher
Heuit Pamela Toy Van
Jian-Ai Xuan
Original Assignee
Schering Ag
Richard Harkins
Richard J Lin
May Luke
Felipe Monteclaro
Deborah Parkes
Gordon Parry
Renate Steinbrecher
Heuit Pamela Toy Van
Xuan Jian Ai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Richard Harkins, Richard J Lin, May Luke, Felipe Monteclaro, Deborah Parkes, Gordon Parry, Renate Steinbrecher, Heuit Pamela Toy Van, Xuan Jian Ai filed Critical Schering Ag
Priority to JP2001544345A priority Critical patent/JP2003533177A/en
Priority to AU43064/01A priority patent/AU4306401A/en
Priority to EP00992356A priority patent/EP1234037A2/en
Publication of WO2001042472A2 publication Critical patent/WO2001042472A2/en
Publication of WO2001042472A3 publication Critical patent/WO2001042472A3/en
Priority to NO20022542A priority patent/NO20022542L/en
Priority to HK03101484.8A priority patent/HK1049352A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel transcription factor polypeptides, designated PROST-Ets, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to methods for utilizing the polynucleotides and polypeptides in research, diagnosis, and therapeutic applications.
PCT/US2000/042295 1999-11-30 2000-11-29 DNA ENCODING A NOVEL PROST-Ets POLYPEPTIDE WO2001042472A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001544345A JP2003533177A (en) 1999-11-30 2000-11-29 DNA encoding novel PROST-Ets polypeptide
AU43064/01A AU4306401A (en) 1999-11-30 2000-11-29 Dna encoding a novel prost-ets polypeptide
EP00992356A EP1234037A2 (en) 1999-11-30 2000-11-29 DNA ENCODING A NOVEL PROST-Ets POLYPEPTIDE
NO20022542A NO20022542L (en) 1999-11-30 2002-05-29 DNA encoding a new Ets polypeptide
HK03101484.8A HK1049352A1 (en) 1999-11-30 2003-02-28 Dna encoding a novel prost-ets polypeptide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16818299P 1999-11-30 1999-11-30
US60/168,182 1999-11-30
US71815900A 2000-11-21 2000-11-21
US09/718,159 2000-11-21

Publications (2)

Publication Number Publication Date
WO2001042472A2 WO2001042472A2 (en) 2001-06-14
WO2001042472A3 true WO2001042472A3 (en) 2002-05-10

Family

ID=26863872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042295 WO2001042472A2 (en) 1999-11-30 2000-11-29 DNA ENCODING A NOVEL PROST-Ets POLYPEPTIDE

Country Status (6)

Country Link
EP (1) EP1234037A2 (en)
JP (1) JP2003533177A (en)
AU (1) AU4306401A (en)
HK (1) HK1049352A1 (en)
NO (1) NO20022542L (en)
WO (1) WO2001042472A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7867731B2 (en) 1998-11-04 2011-01-11 Novartis Vaccines And Diagnostics, Inc. HX2004-6 polypeptide expressed in cancerous cells
AU5132800A (en) 1999-05-14 2000-12-05 Chiron Corporation Expression of ets-domain proteins in cancer
CA2443123A1 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
TWI570662B (en) * 2016-04-27 2017-02-11 國立彰化師範大學 Gene synthesis teaching system and method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006589A1 (en) * 1998-07-31 2000-02-10 Human Genome Sciences, Inc. Prostate derived ets factor
WO2000055173A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human breast and ovarian cancer associated gene sequences and polypeptides
WO2000070092A1 (en) * 1999-05-14 2000-11-23 Chiron Corporation Expression of ets-domain proteins in cancer
US6265565B1 (en) * 1998-04-03 2001-07-24 Incyte Genomics, Inc. Prostate associated Ets protein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265565B1 (en) * 1998-04-03 2001-07-24 Incyte Genomics, Inc. Prostate associated Ets protein
WO2000006589A1 (en) * 1998-07-31 2000-02-10 Human Genome Sciences, Inc. Prostate derived ets factor
WO2000055173A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human breast and ovarian cancer associated gene sequences and polypeptides
WO2000070092A1 (en) * 1999-05-14 2000-11-23 Chiron Corporation Expression of ets-domain proteins in cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI Hinxton, UK; 14 December 1998 (1998-12-14), OETTGEN ET AL, XP002183898 *
OETTGEN ET AL: "PDEF, a novel prostate epithelium-specific Ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 2, January 2000 (2000-01-01), pages 1216 - 1225, XP002148117 *
See also references of EP1234037A2 *
SEMENTCHENKO V I ET AL: "ETS2 FUNCTION IS REQUIRED TO MAINTAIN THE TRANSFORMED STATE OF HUMAN PROSTATE CANCER CELLS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 17, no. 22, 1998, pages 2883 - 2888, XP000946164, ISSN: 0950-9232 *
TRAIL P A ET AL: "Monoclonal antibody drug conjugates in the treatment of cancer", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 11, no. 5, 1 October 1999 (1999-10-01), pages 584 - 588, XP004257589, ISSN: 0952-7915 *
YAMADA NAOKO ET AL: "Cloning and expression of the mouse Pse gene encoding a novel Ets family member.", GENE (AMSTERDAM), vol. 241, no. 2, 11 January 2000 (2000-01-11), pages 267 - 274, XP001041527, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
NO20022542L (en) 2002-07-29
JP2003533177A (en) 2003-11-11
EP1234037A2 (en) 2002-08-28
AU4306401A (en) 2001-06-18
WO2001042472A2 (en) 2001-06-14
HK1049352A1 (en) 2003-05-09
NO20022542D0 (en) 2002-05-29

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