WO2001041735A3 - Thermosensitive biodegradable hydrogels based on low molecular weight pluronics - Google Patents

Thermosensitive biodegradable hydrogels based on low molecular weight pluronics Download PDF

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Publication number
WO2001041735A3
WO2001041735A3 PCT/US2000/032130 US0032130W WO0141735A3 WO 2001041735 A3 WO2001041735 A3 WO 2001041735A3 US 0032130 W US0032130 W US 0032130W WO 0141735 A3 WO0141735 A3 WO 0141735A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular weight
low molecular
biodegradable hydrogels
hydrogels based
pluronics
Prior art date
Application number
PCT/US2000/032130
Other languages
French (fr)
Other versions
WO2001041735A2 (en
Inventor
Subodh Shah
Andrech Khachatouri
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to AU17926/01A priority Critical patent/AU1792601A/en
Publication of WO2001041735A2 publication Critical patent/WO2001041735A2/en
Publication of WO2001041735A3 publication Critical patent/WO2001041735A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

The present invention relates to the use of thermosensitive, biodegradable hydrogels, consisting of a block copolymer of poly(d,1- or 1-lactic acid) (PLA) or poly(lactide-co-glycolide) (PLGA) and low molecular weight Pluronics, for the sustained delivery of biologically active agents.
PCT/US2000/032130 1999-12-07 2000-11-21 Thermosensitive biodegradable hydrogels based on low molecular weight pluronics WO2001041735A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17926/01A AU1792601A (en) 1999-12-07 2000-11-21 Thermosensitive biodegradable hydrogels based on low molecular weight pluronics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45605699A 1999-12-07 1999-12-07
US09/456,056 1999-12-07

Publications (2)

Publication Number Publication Date
WO2001041735A2 WO2001041735A2 (en) 2001-06-14
WO2001041735A3 true WO2001041735A3 (en) 2001-12-13

Family

ID=23811247

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032130 WO2001041735A2 (en) 1999-12-07 2000-11-21 Thermosensitive biodegradable hydrogels based on low molecular weight pluronics

Country Status (2)

Country Link
AU (1) AU1792601A (en)
WO (1) WO2001041735A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2466998A1 (en) 2001-11-12 2003-05-22 Alkermes Controlled Therapeutics, Inc. Biocompatible polymer blends and uses thereof
US7151077B2 (en) 2004-03-29 2006-12-19 Halliburton Energy Services, Inc. Polymersome compositions and associated methods of use
US7252834B2 (en) 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
CN101500606B (en) * 2005-06-24 2013-12-04 杜克大学 A direct drug delivery system based on thermally responsive biopolymers
FR2932070B1 (en) 2008-06-10 2012-08-17 Oreal MAKE-UP AND / OR CARE OF LASHES
FR2940761B1 (en) 2009-01-07 2012-12-28 Polymerexpert Sa ANTI-ROUNDER COMPOSITION CONTAINING A THERMOGELIFYING POLYMER
US8444624B2 (en) 2009-10-19 2013-05-21 Vatrix Medical, Inc. Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections
US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
US9937255B2 (en) 2011-05-18 2018-04-10 Nectero Medical, Inc. Coated balloons for blood vessel stabilization
US9408785B2 (en) 2012-10-15 2016-08-09 L'oreal Hair styling compositions containing aqueous wax dispersions
US10626294B2 (en) 2012-10-15 2020-04-21 L'oreal Aqueous wax dispersions containing volatile solvents
US10413496B2 (en) 2012-10-15 2019-09-17 L'oreal Aqueous wax dispersions
US10561596B2 (en) 2014-04-11 2020-02-18 L'oreal Compositions and dispersions containing particles comprising a polymer
FR3091996B1 (en) 2019-01-24 2021-01-29 Les Laboratoires Brothier HEALING COMPOSITION

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357401A2 (en) * 1988-08-31 1990-03-07 THERATECH, INC. (a Delaware Corporation) Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
WO1997005185A2 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
WO1997015287A1 (en) * 1995-10-25 1997-05-01 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers
WO1999007416A1 (en) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS
WO1999007343A1 (en) * 1997-08-08 1999-02-18 University Of Utah Research Foundation Injectable biodegradable block copolymer gels for use in drug delivery
WO1999018142A1 (en) * 1997-10-03 1999-04-15 Macromed, Inc. BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES
WO2000000222A1 (en) * 1998-06-30 2000-01-06 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents
WO2000038651A1 (en) * 1998-12-23 2000-07-06 Amgen Inc. BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357401A2 (en) * 1988-08-31 1990-03-07 THERATECH, INC. (a Delaware Corporation) Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
WO1997005185A2 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
WO1997015287A1 (en) * 1995-10-25 1997-05-01 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers
WO1999007416A1 (en) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS
WO1999007343A1 (en) * 1997-08-08 1999-02-18 University Of Utah Research Foundation Injectable biodegradable block copolymer gels for use in drug delivery
WO1999018142A1 (en) * 1997-10-03 1999-04-15 Macromed, Inc. BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES
WO2000000222A1 (en) * 1998-06-30 2000-01-06 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents
WO2000038651A1 (en) * 1998-12-23 2000-07-06 Amgen Inc. BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS

Also Published As

Publication number Publication date
AU1792601A (en) 2001-06-18
WO2001041735A2 (en) 2001-06-14

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