WO2001037874A3 - Treatment of psoriasis by using an antibody to tnf alpha - Google Patents

Treatment of psoriasis by using an antibody to tnf alpha Download PDF

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Publication number
WO2001037874A3
WO2001037874A3 PCT/US2000/042161 US0042161W WO0137874A3 WO 2001037874 A3 WO2001037874 A3 WO 2001037874A3 US 0042161 W US0042161 W US 0042161W WO 0137874 A3 WO0137874 A3 WO 0137874A3
Authority
WO
WIPO (PCT)
Prior art keywords
psoriasis
treatment
antibody
tnf alpha
antigen
Prior art date
Application number
PCT/US2000/042161
Other languages
French (fr)
Other versions
WO2001037874A2 (en
Inventor
David J Shealy
Original Assignee
Centocor Inc
David J Shealy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc, David J Shealy filed Critical Centocor Inc
Priority to AU30824/01A priority Critical patent/AU3082401A/en
Publication of WO2001037874A2 publication Critical patent/WO2001037874A2/en
Publication of WO2001037874A3 publication Critical patent/WO2001037874A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides for uses of an anti-TNFα antibody or an antigen-binding fragment thereof for the manufacture of a medicament for use in the treatment of psoriasis or psoriatic skin lesions in an individual in need thereof.
PCT/US2000/042161 1999-11-24 2000-11-15 Treatment of psoriasis by using an antibody to tnf alpha WO2001037874A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30824/01A AU3082401A (en) 1999-11-24 2000-11-15 Therapy of psoriasis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16747099P 1999-11-24 1999-11-24
US60/167,470 1999-11-24

Publications (2)

Publication Number Publication Date
WO2001037874A2 WO2001037874A2 (en) 2001-05-31
WO2001037874A3 true WO2001037874A3 (en) 2002-01-10

Family

ID=22607484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042161 WO2001037874A2 (en) 1999-11-24 2000-11-15 Treatment of psoriasis by using an antibody to tnf alpha

Country Status (2)

Country Link
AU (1) AU3082401A (en)
WO (1) WO2001037874A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906373B2 (en) 2002-07-19 2014-12-09 Abbvie Biotechnology Ltd. Use of TNF-alpha inhibitor for treatment of psoriasis
US8961973B2 (en) 2004-04-09 2015-02-24 Abbvie Biotechnology Ltd. Multiple-variable dose regimen for treating TNFα-related disorders
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20030206898A1 (en) * 2002-04-26 2003-11-06 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
CN102764436A (en) * 2002-07-19 2012-11-07 艾博特生物技术有限公司 Treatment of TNF alpha related disorders
US10080779B2 (en) 2004-12-15 2018-09-25 Universite D'angers Method for increasing the expression of anti-microbial peptides by keratinocytes comprising administering a composition comprising IL-17, TNF-alpha and OSM
EP1671642A1 (en) * 2004-12-15 2006-06-21 Universite D'angers Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof.
EP2666472A3 (en) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Uses and compositions for treatment of psoriatic arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
JP2023554200A (en) 2020-12-09 2023-12-26 エイチケー イノ．エヌ コーポレーション Anti-OX40L antibody, anti-OX40L and anti-TNFα bispecific antibody, and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001472A1 (en) * 1990-07-19 1992-02-06 Celltech Limited Multivalent anti-cytokine immunoglobulins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001472A1 (en) * 1990-07-19 1992-02-06 Celltech Limited Multivalent anti-cytokine immunoglobulins

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
C. ANTONI ET AL.: "Successful treatment of psoriatic arthritis with infliximab in a MRI controlled study", JOURNAL OF RHEUMATOLOGY, vol. 27, no. suppl. 59, August 2000 (2000-08-01), Toronto, Canada, pages 24, XP000990586 *
C. ANTONI ET AL.: "Successful treatment of severe psoriatic arthritis with infliximab.", ARTHRITIS & RHEUMATISM, vol. 42, September 1999 (1999-09-01), New York, NY, USA, pages S371, XP002165648 *
C. BONIFATI ET AL.: "Correlated increases of tumour necrosis factor-alpha, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients - relationships with disease severity.", CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 19, no. 5, September 1994 (1994-09-01), Oxford, GB, pages 383 - 387, XP000990570 *
C. OH ET AL.: "Treatment with anti-tumor necrosis factor alpha (TNF alpha) monoclonal antibody dramatically decreases the clinical activity of psoriatis lesions.", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 42, no. 5 part 1, May 2000 (2000-05-01), St. Louis, MO, USA, pages 829 - 830, XP000990581 *
F. BAERT ET AL.: "Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis", GASTROENTEROLOGY, vol. 116, no. 1, January 1999 (1999-01-01), New York, NY, USA, pages 22 - 28, XP002165649 *
K. MACE ET AL.: "Pharmacodynamics of cA2: implications for immunotherapy.", EUROPEAN CYTOKINE NETWORK, vol. 7, no. 2, April 1996 (1996-04-01), Montrouge, pages 308, XP000990601 *
M. FELDMANN ET AL.: "TNFalpha is an effective therapeutic target for rheumatoid arthritis.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 766, 1995, New York, NY, USA, pages 272 - 278, XP000990602 *
P. ETTEHADI ET AL.: "Elevated tumour necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions.", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 96, no. 1, April 1994 (1994-04-01), Oxford, GB, pages 146 - 151, XP000990589 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906373B2 (en) 2002-07-19 2014-12-09 Abbvie Biotechnology Ltd. Use of TNF-alpha inhibitor for treatment of psoriasis
US8961973B2 (en) 2004-04-09 2015-02-24 Abbvie Biotechnology Ltd. Multiple-variable dose regimen for treating TNFα-related disorders
US8961974B2 (en) 2004-04-09 2015-02-24 Abbvie Biotechnology Ltd. Multiple-variable dose regimen for treating TNFα-related disorders
US8986693B1 (en) 2004-04-09 2015-03-24 Abbvie Biotechnology Ltd. Use of TNFα inhibitor for treatment of psoriasis
US9187559B2 (en) 2004-04-09 2015-11-17 Abbvie Biotechnology Ltd Multiple-variable dose regimen for treating idiopathic inflammatory bowel disease
US9499615B2 (en) 2004-04-09 2016-11-22 Abbvie Biotechnology Ltd Multiple-variable dose regimen for treating idiopathic inflammatory bowel disease
US9512216B2 (en) 2004-04-09 2016-12-06 Abbvie Biotechnology Ltd. Use of TNFα inhibitor
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
US9284370B1 (en) 2007-06-11 2016-03-15 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis

Also Published As

Publication number Publication date
WO2001037874A2 (en) 2001-05-31
AU3082401A (en) 2001-06-04

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