WO2001036655A3 - Method for optimization of a medium for glycopeptide fermentation - Google Patents

Method for optimization of a medium for glycopeptide fermentation Download PDF

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Publication number
WO2001036655A3
WO2001036655A3 PCT/US2000/028858 US0028858W WO0136655A3 WO 2001036655 A3 WO2001036655 A3 WO 2001036655A3 US 0028858 W US0028858 W US 0028858W WO 0136655 A3 WO0136655 A3 WO 0136655A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycopeptide
fermentation
optimization
medium
production
Prior art date
Application number
PCT/US2000/028858
Other languages
French (fr)
Other versions
WO2001036655A2 (en
Inventor
Brian Edward Hartman
Robert Joseph Juni Strobel
Gary Robert Sullivan
Original Assignee
Lilly Co Eli
Brian Edward Hartman
Robert Joseph Juni Strobel
Gary Robert Sullivan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Brian Edward Hartman, Robert Joseph Juni Strobel, Gary Robert Sullivan filed Critical Lilly Co Eli
Priority to AU15718/01A priority Critical patent/AU1571801A/en
Publication of WO2001036655A2 publication Critical patent/WO2001036655A2/en
Publication of WO2001036655A3 publication Critical patent/WO2001036655A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin

Abstract

The present invention provides a process for optimizing a fermentation process for the production of a glycopeptide nucleus by means of particle swarm optimization. In addition, an improved fermentation medium for the production of the glycopeptide nucleus was found which is significantly different and more potent than media identified by more conventional optimization methods.
PCT/US2000/028858 1999-11-12 2000-10-27 Method for optimization of a medium for glycopeptide fermentation WO2001036655A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15718/01A AU1571801A (en) 1999-11-12 2000-10-27 Improved fermentation process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16515399P 1999-11-12 1999-11-12
US60/165,153 1999-11-12

Publications (2)

Publication Number Publication Date
WO2001036655A2 WO2001036655A2 (en) 2001-05-25
WO2001036655A3 true WO2001036655A3 (en) 2002-03-07

Family

ID=22597652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028858 WO2001036655A2 (en) 1999-11-12 2000-10-27 Method for optimization of a medium for glycopeptide fermentation

Country Status (2)

Country Link
AU (1) AU1571801A (en)
WO (1) WO2001036655A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452697B2 (en) 2003-09-25 2008-11-18 Allergan, Inc. Chromatographic method and system for purifying a botulinum toxin
US7148041B2 (en) 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
US7160699B2 (en) 2003-09-25 2007-01-09 Allergan, Inc. Media for clostridium bacterium and processes for obtaining a clostridial toxin
MXPA06009853A (en) 2005-03-03 2007-03-29 Allergan Inc Media for clostridium bacterium and processes for obtaining a clostridial toxin.
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CN103559396B (en) * 2013-10-31 2016-06-01 华北水利水电大学 Based on the automatic dispensary stock's allocation optimization method improving chaos particle cluster algorithm
CN104805161A (en) * 2014-01-29 2015-07-29 上海医药工业研究院 Oritavancin precursor A82846B production method and mediums
CN107557415B (en) * 2016-06-30 2021-03-02 上海医药工业研究院 Fermentation medium and production process for producing oritavancin precursor A82846B
CN109929895B (en) * 2019-04-02 2021-05-18 博瑞生物医药泰兴市有限公司 Acid degradation liquid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265071A1 (en) * 1986-09-19 1988-04-27 Eli Lilly And Company Glycopeptide antibiotics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265071A1 (en) * 1986-09-19 1988-04-27 Eli Lilly And Company Glycopeptide antibiotics

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KENNEDY J ET AL: "Particle swarm optimization", 1995 IEEE INTERNATIONAL CONFERENCE ON NEURAL NETWORKS PROCEEDINGS (CAT. NO.95CH35828), PROCEEDINGS OF ICNN 95 - INTERNATIONAL CONFERENCE ON NEURAL NETWORKS, PERTH, WA, AUSTRALIA, 27 NOV.-1 DEC. 1995, 1995, New York, NY, USA, IEEE, USA, pages 1942 - 1948 vol.4, XP002173494, ISBN: 0-7803-2768-3 *
MCINTYRE JAMES J ET AL: "Vancomycin production in batch and continuous culture.", BIOTECHNOLOGY AND BIOENGINEERING, vol. 49, no. 4, 1996, pages 412 - 420, XP002173493, ISSN: 0006-3592 *
ZUZEK M ET AL: "Optimization of fermentation medium by a modified method of genetic algorithms.", BIOTECHNOLOGY TECHNIQUES, vol. 10, no. 12, 1996, pages 991 - 996, XP000101453, ISSN: 0951-208X *
ZWICKER N ET AL: "Optimization of fermentation conditions for the production of ethylene-diamine-disuccinic acid by Amycolatopsis orientalis.", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, vol. 19, no. 4, October 1997 (1997-10-01), pages 280 - 285, XP001010427 *

Also Published As

Publication number Publication date
WO2001036655A2 (en) 2001-05-25
AU1571801A (en) 2001-05-30

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