WO2001036619A3 - Cloning and characterization of the cap gene promoter - Google Patents

Cloning and characterization of the cap gene promoter Download PDF

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Publication number
WO2001036619A3
WO2001036619A3 PCT/US2000/028686 US0028686W WO0136619A3 WO 2001036619 A3 WO2001036619 A3 WO 2001036619A3 US 0028686 W US0028686 W US 0028686W WO 0136619 A3 WO0136619 A3 WO 0136619A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel polynucleotides
cloning
characterization
gene promoter
cap gene
Prior art date
Application number
PCT/US2000/028686
Other languages
French (fr)
Other versions
WO2001036619A2 (en
Inventor
Christian A Baumann
Vered Ribon
Alan Robert Saltiel
Original Assignee
Warner Lambert Co
Christian A Baumann
Vered Ribon
Alan Robert Saltiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Christian A Baumann, Vered Ribon, Alan Robert Saltiel filed Critical Warner Lambert Co
Priority to JP2001538498A priority Critical patent/JP2003517302A/en
Priority to AU12096/01A priority patent/AU1209601A/en
Priority to CA002385090A priority patent/CA2385090A1/en
Priority to EP00973600A priority patent/EP1232261A2/en
Priority to BR0015542-0A priority patent/BR0015542A/en
Publication of WO2001036619A2 publication Critical patent/WO2001036619A2/en
Publication of WO2001036619A3 publication Critical patent/WO2001036619A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to novel polynucleotides that contain peroxisome proliferator response elements (PPREs). The invention also describes vectors and host cells comprising the novel polynucleotides. The invention further describes methods for using the novel polynucleotides, gene therapy applications, diagnostics for syndromes involving insulin resistance, development of proprietary screening strategies for inhibitors of ligands or proteins that bind to, associate with, or interact with the CAP promoter.
PCT/US2000/028686 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter WO2001036619A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001538498A JP2003517302A (en) 1999-11-12 2000-10-17 Cloning and characterization of CAP gene promoter
AU12096/01A AU1209601A (en) 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter
CA002385090A CA2385090A1 (en) 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter
EP00973600A EP1232261A2 (en) 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter
BR0015542-0A BR0015542A (en) 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16522199P 1999-11-12 1999-11-12
US60/165,221 1999-11-12

Publications (2)

Publication Number Publication Date
WO2001036619A2 WO2001036619A2 (en) 2001-05-25
WO2001036619A3 true WO2001036619A3 (en) 2002-01-17

Family

ID=22597977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028686 WO2001036619A2 (en) 1999-11-12 2000-10-17 Cloning and characterization of the cap gene promoter

Country Status (7)

Country Link
EP (1) EP1232261A2 (en)
JP (1) JP2003517302A (en)
AU (1) AU1209601A (en)
BR (1) BR0015542A (en)
CA (1) CA2385090A1 (en)
TR (1) TR200201302T2 (en)
WO (1) WO2001036619A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015155A1 (en) * 2003-08-08 2007-01-18 Hideki Endoh Novel protein usable in screening drug improving type 2 diabetes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648840A2 (en) * 1993-10-13 1995-04-19 Northeastern Ohio Universities Cholesterol 7alpha-hydroxylase gene regulatory elements and transcription factors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648840A2 (en) * 1993-10-13 1995-04-19 Northeastern Ohio Universities Cholesterol 7alpha-hydroxylase gene regulatory elements and transcription factors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUMANN C A ET AL: "CLONING AND CHARACTERIZATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR-GAMMA-RESPONSIVE ELEMENT IN THE PROMOTER OF THE CAP GENE", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 275, no. 13, 2000, pages 9131 - 9135, XP000907448, ISSN: 0021-9258 *
FROHNERT B I ET AL: "IDENTIFICATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR-RESPONSIVE ELEMENT IN THE MURINE FATTY ACID TRANSPORT PROTEIN GENE", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 274, no. 7, 1999, pages 3970 - 3977, XP000907447, ISSN: 0021-9258 *
RIBON VERED ET AL: "A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 2, February 1998 (1998-02-01), pages 872 - 879, XP002168128, ISSN: 0270-7306 *
RIBON VERED ET AL: "Thiazolidinediones and insulin resistance: Peroxisome proliferator-activated receptor gamma activation stimulates expression of the CAP gene.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 25, December 1998 (1998-12-01), Dec., 1998, pages 14751 - 14756, XP002168127, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
JP2003517302A (en) 2003-05-27
CA2385090A1 (en) 2001-05-25
AU1209601A (en) 2001-05-30
BR0015542A (en) 2002-12-31
EP1232261A2 (en) 2002-08-21
WO2001036619A2 (en) 2001-05-25
TR200201302T2 (en) 2002-08-21

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