WO2001036362A3 - Solid support mediated method for the synthesis of ketone oxime linkers and method of producing libraries of ketones therefrom - Google Patents

Solid support mediated method for the synthesis of ketone oxime linkers and method of producing libraries of ketones therefrom Download PDF

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Publication number
WO2001036362A3
WO2001036362A3 PCT/US2000/028871 US0028871W WO0136362A3 WO 2001036362 A3 WO2001036362 A3 WO 2001036362A3 US 0028871 W US0028871 W US 0028871W WO 0136362 A3 WO0136362 A3 WO 0136362A3
Authority
WO
WIPO (PCT)
Prior art keywords
ketones
therefrom
synthesis
solid support
ketone oxime
Prior art date
Application number
PCT/US2000/028871
Other languages
French (fr)
Other versions
WO2001036362A2 (en
Inventor
Salvatore Donato Lepore
Michael Robert Wiley
Original Assignee
Lilly Co Eli
Salvatore Donato Lepore
Michael Robert Wiley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Salvatore Donato Lepore, Michael Robert Wiley filed Critical Lilly Co Eli
Priority to AU15720/01A priority Critical patent/AU1572001A/en
Publication of WO2001036362A2 publication Critical patent/WO2001036362A2/en
Publication of WO2001036362A3 publication Critical patent/WO2001036362A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention provides a method of synthesizing a compound, comprising reacting a compound of formula (I) with a compound of formula (III) to form a compound of formula (IV)
PCT/US2000/028871 1999-11-12 2000-11-02 Solid support mediated method for the synthesis of ketone oxime linkers and method of producing libraries of ketones therefrom WO2001036362A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15720/01A AU1572001A (en) 1999-11-12 2000-11-02 Solid support mediated method for the synthesis of ketone oxime linkers and method of producing libraries of ketones therefrom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16532799P 1999-11-12 1999-11-12
US60/165,327 1999-11-12

Publications (2)

Publication Number Publication Date
WO2001036362A2 WO2001036362A2 (en) 2001-05-25
WO2001036362A3 true WO2001036362A3 (en) 2002-03-14

Family

ID=22598453

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028871 WO2001036362A2 (en) 1999-11-12 2000-11-02 Solid support mediated method for the synthesis of ketone oxime linkers and method of producing libraries of ketones therefrom

Country Status (2)

Country Link
AU (1) AU1572001A (en)
WO (1) WO2001036362A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9126890B2 (en) * 2011-10-20 2015-09-08 International Flavors & Fragrances Inc. Low volatile reactive malodor counteractives and methods of use thereof
US10226544B2 (en) 2015-06-05 2019-03-12 International Flavors & Fragrances Inc. Malodor counteracting compositions
CN113461503A (en) * 2021-08-18 2021-10-01 杭州臻挚生物科技有限公司 Preparation method of trifluoro acetophenone derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
P.M. WORSTER ET AL.: "Asymmetric Synthesis of 2-Alkylcyclohexanones an Solid Phases", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 18, no. 3, 1979, VERLAG CHEMIE. WEINHEIM., DE, pages 221 - 222, XP002168441, ISSN: 0570-0833 *
SHERMAN, MARK A. ET AL: "Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding", MOL. PHARMACOL. (1986), 29(6), 589-98, XP001004756 *

Also Published As

Publication number Publication date
WO2001036362A2 (en) 2001-05-25
AU1572001A (en) 2001-05-30

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