WO2001034660A3 - Criblage et analyse radiographiques de polymeres, de specialites chimiques et de catalyseurs - Google Patents

Criblage et analyse radiographiques de polymeres, de specialites chimiques et de catalyseurs Download PDF

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Publication number
WO2001034660A3
WO2001034660A3 PCT/US2000/030720 US0030720W WO0134660A3 WO 2001034660 A3 WO2001034660 A3 WO 2001034660A3 US 0030720 W US0030720 W US 0030720W WO 0134660 A3 WO0134660 A3 WO 0134660A3
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WIPO (PCT)
Prior art keywords
catalysts
methods
polymers
analysis
chemical
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PCT/US2000/030720
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English (en)
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WO2001034660A2 (fr
Inventor
Christopher D Tagge
Robert B Wilson
Seajin Oh
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Stanford Res Inst Int
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Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Priority to AU14765/01A priority Critical patent/AU1476501A/en
Publication of WO2001034660A2 publication Critical patent/WO2001034660A2/fr
Publication of WO2001034660A3 publication Critical patent/WO2001034660A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/088—Investigating volume, surface area, size or distribution of pores; Porosimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
    • G01N5/04—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by removing a component, e.g. by evaporation, and weighing the remainder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00574—Chemical means radioactive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Combustion & Propulsion (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention porte sur des procédés recourant à la radiographie pour l'analyse de composés chimiques tels que des polymères, des spécialités chimiques et des catalyseurs, et en particulier sur des procédés exécutables en fort parallélisme en vue de la synthèse et de l'analyse de composés chimiques, avec un rendement élevé ou de manière combinatoire. L'invention prévoit à cet effet un substrat comportant plusieurs zones de réaction, puis des étapes de polymérisation, synthèses ou adsorption exécutées avec ou sans réactifs radiomarqués. La radioactivité des produits résultants fournit une mesure de différentes propriétés physiques. Le procédé de l'invention peut par exemple servir à déterminer la teneur en comonomères de polymères, la productivité de catalyseurs et/ou l'incorporation d'un réactif dans une spécialité chimique. En outre, l'invention prévoit des moyens de déterminer différentes propriétés chimiques et physiques de catalyseurs poreux dont la surface efficace, le nombre de sites actifs, le nombre de sites acides ou basiques, la distribution en taille des pores, et la chimiosorption.
PCT/US2000/030720 1999-11-09 2000-11-09 Criblage et analyse radiographiques de polymeres, de specialites chimiques et de catalyseurs WO2001034660A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14765/01A AU1476501A (en) 1999-11-09 2000-11-09 Screening and analysis of polymers, specialty chemicals and catalysts using radiography

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16434299P 1999-11-09 1999-11-09
US60/164,342 1999-11-09
US16722799P 1999-11-24 1999-11-24
US60/167,227 1999-11-24
US22441100P 2000-08-10 2000-08-10
US60/224,411 2000-08-10

Publications (2)

Publication Number Publication Date
WO2001034660A2 WO2001034660A2 (fr) 2001-05-17
WO2001034660A3 true WO2001034660A3 (fr) 2001-11-29

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PCT/US2000/030720 WO2001034660A2 (fr) 1999-11-09 2000-11-09 Criblage et analyse radiographiques de polymeres, de specialites chimiques et de catalyseurs

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AU (1) AU1476501A (fr)
WO (1) WO2001034660A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206988A1 (de) † 2002-02-19 2003-08-21 Basf Ag Verfahren mit hohem Probendurchsatz zur Bestimmung der Qualität von Polymerisationskatalysatoren
GB0206117D0 (en) 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
CN105116013A (zh) * 2015-04-23 2015-12-02 山东农业大学 一种确定金属离子对蛋白酶水解大豆分离蛋白影响的方法

Citations (8)

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Publication number Priority date Publication date Assignee Title
DE1442527A1 (de) * 1964-02-15 1968-10-31 Grillo Werke Ag Verwendung von anodischen Metalloxydschichten als dosierender Traeger
US3814769A (en) * 1969-05-01 1974-06-04 Mallinckrodt Chemical Works Catalyzed radioiodine exchange
US5088316A (en) * 1989-09-27 1992-02-18 Versar, Inc. Apparatus and method for testing material samples for gas diffusion characteristics
WO1997028168A1 (fr) * 1996-02-01 1997-08-07 Pharmagenics, Inc. Oligomeres d'ester phosphoreux non nucleotidiques
WO1997032208A1 (fr) * 1996-02-28 1997-09-04 Technology Licensing Co. L.L.C. Appareil et procede d'essai de catalyseurs
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
WO1999005318A1 (fr) * 1997-07-22 1999-02-04 Symyx Technologies Codage de banques organometalliques
WO1999051546A1 (fr) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Approche combinatoire parallele de la decouverte et de l'optimisation de catalyseurs et leurs utilisations

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1442527A1 (de) * 1964-02-15 1968-10-31 Grillo Werke Ag Verwendung von anodischen Metalloxydschichten als dosierender Traeger
US3814769A (en) * 1969-05-01 1974-06-04 Mallinckrodt Chemical Works Catalyzed radioiodine exchange
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5088316A (en) * 1989-09-27 1992-02-18 Versar, Inc. Apparatus and method for testing material samples for gas diffusion characteristics
WO1997028168A1 (fr) * 1996-02-01 1997-08-07 Pharmagenics, Inc. Oligomeres d'ester phosphoreux non nucleotidiques
WO1997032208A1 (fr) * 1996-02-28 1997-09-04 Technology Licensing Co. L.L.C. Appareil et procede d'essai de catalyseurs
WO1999005318A1 (fr) * 1997-07-22 1999-02-04 Symyx Technologies Codage de banques organometalliques
WO1999051546A1 (fr) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Approche combinatoire parallele de la decouverte et de l'optimisation de catalyseurs et leurs utilisations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDERSON B G ET AL: "IMAGING OF HYDROCARBON REACTIONS IN ZEOLITE PACKED-BED REACTORS USING POSITRON EMISSION PROFILING", CATALYSIS LETTERS,BALTZER, SCIENTIFIC PUBL, BASEL,CH, vol. 56, no. 2/03, December 1998 (1998-12-01), pages 137 - 144, XP000802188, ISSN: 1011-372X *
MCNEILL AND STRAITON: "Copolymerization of methyl methacrylate with 36Cl-Vinyl Chloride", EUROPEAN POLYMER JOURNAL, vol. 13, 1977, pages 17 - 18, XP000997685 *
SCHRÖDER U AND SCHÖÖN N-H: "Radioactive Tracer Techniques for Study of Reactions on Industrial Catalysts", JOURNAL OF CATALYSIS, vol. 143, 1993, pages 381 - 387, XP002169192 *

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WO2001034660A2 (fr) 2001-05-17
AU1476501A (en) 2001-06-06

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