WO2001033220A3 - The use of the area postreama to identify therapeutic compounds - Google Patents

The use of the area postreama to identify therapeutic compounds Download PDF

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Publication number
WO2001033220A3
WO2001033220A3 PCT/US2000/019497 US0019497W WO0133220A3 WO 2001033220 A3 WO2001033220 A3 WO 2001033220A3 US 0019497 W US0019497 W US 0019497W WO 0133220 A3 WO0133220 A3 WO 0133220A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic compounds
identify therapeutic
postreama
area
area postreama
Prior art date
Application number
PCT/US2000/019497
Other languages
French (fr)
Other versions
WO2001033220A2 (en
Inventor
Andrew Young
Bronislava Gedulin
Original Assignee
Amylin Pharmaceuticals Inc
Andrew Young
Bronislava Gedulin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amylin Pharmaceuticals Inc, Andrew Young, Bronislava Gedulin filed Critical Amylin Pharmaceuticals Inc
Priority to JP2001535054A priority Critical patent/JP2003513281A/en
Priority to EP00948730A priority patent/EP1194778A2/en
Priority to AU62191/00A priority patent/AU6219100A/en
Publication of WO2001033220A2 publication Critical patent/WO2001033220A2/en
Publication of WO2001033220A3 publication Critical patent/WO2001033220A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods for identifying or screening or characterizing or assaying or isolating known or candidate compounds that stimulate or inhibit area postrema activity, for example area postrema activities relating to fuel homeostasis.
PCT/US2000/019497 1999-07-13 2000-07-13 The use of the area postreama to identify therapeutic compounds WO2001033220A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001535054A JP2003513281A (en) 1999-07-13 2000-07-13 Use of membranes, cells and tissues from the last field to identify therapeutic compounds
EP00948730A EP1194778A2 (en) 1999-07-13 2000-07-13 The use of the area postrema to identify therapeutic compounds
AU62191/00A AU6219100A (en) 1999-07-13 2000-07-13 The use of membranes, cells and tissue from the area postrema to identify therapeutic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14383099P 1999-07-13 1999-07-13
US60/143,830 1999-07-13

Publications (2)

Publication Number Publication Date
WO2001033220A2 WO2001033220A2 (en) 2001-05-10
WO2001033220A3 true WO2001033220A3 (en) 2001-10-25

Family

ID=22505854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019497 WO2001033220A2 (en) 1999-07-13 2000-07-13 The use of the area postreama to identify therapeutic compounds

Country Status (4)

Country Link
EP (1) EP1194778A2 (en)
JP (1) JP2003513281A (en)
AU (1) AU6219100A (en)
WO (1) WO2001033220A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002213314A1 (en) 2000-10-16 2002-04-29 Tradecard, Inc. Improved full service trade system
WO2007038672A2 (en) 2005-09-28 2007-04-05 Tradecard, Inc. Securitization of a commercial transaction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264372A (en) * 1991-03-15 1993-11-23 Amylin Pharmaceuticals, Inc. Receptor-based screening methods for amylin agonists and antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264372A (en) * 1991-03-15 1993-11-23 Amylin Pharmaceuticals, Inc. Receptor-based screening methods for amylin agonists and antagonists

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. H. HASSEN ET AL.: "Delta versus mu receptors: cardiovascular and respiratory effects of opiate agonists microinjected into nucleus tractus solitarius of cats", REGULATORY PEPTIDES., vol. 4, 1982, ELSEVIER SCIENCE BV., NL, pages 299 - 309, XP000987248, ISSN: 0167-0115 *
B. A. WHELAN ET AL.: "Synthesis and structural, conformational, biochemical, and pharmacological study of new compounds derived from Tropane-3-spiro 4'(5')-imidazoline as potential 5-HT3 receptor antagonists", JOURNAL OF PHARMACEUTICAL SCIENCES., vol. 84, no. 1, January 1995 (1995-01-01), AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON., US, pages 101 - 106, XP002161801, ISSN: 0022-3549 *
K. F. RHODES ET A.: "WAY 100289: pharmacological profile of a novel 5-HT3 receptor antagonist.", DRUG DEVELOPMENT RESEARCH., vol. 28, 1993, NEW YORK, NY, US, pages 128 - 140, XP000987255, ISSN: 0272-4391 *
K. HERRICK-DAVIS ET AL.: "Detection and characterization of a 5HT1D serotonin receptor-GTP binding protein interaction in porcine and bovine brain", SYNAPSE., vol. 3, 1989, WILEY AND SONS, CHICHESTER., GB, pages 325 - 330, XP000618699, ISSN: 0887-4476 *
K. MILLER ET AL.: "Membrane-bound and solubilized brain 5HT3 receptors: improved radioligand binding assays using bovine Area Postrema or rat cortex and the radioligands 3H-GR65630, 3H-BRL43694, and 3H-LY278584.", SYNAPSE., vol. 11, no. 1, 1992, WILEY AND SONS, CHICHESTER., GB, pages 58 - 66, XP000987247, ISSN: 0887-4476 *

Also Published As

Publication number Publication date
JP2003513281A (en) 2003-04-08
EP1194778A2 (en) 2002-04-10
WO2001033220A2 (en) 2001-05-10
AU6219100A (en) 2001-05-14

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