WO2001032912A8 - Use of the jak-stat system in cultured cells to trace effects of tested compounds - Google Patents

Use of the jak-stat system in cultured cells to trace effects of tested compounds

Info

Publication number
WO2001032912A8
WO2001032912A8 PCT/SE2000/002093 SE0002093W WO0132912A8 WO 2001032912 A8 WO2001032912 A8 WO 2001032912A8 SE 0002093 W SE0002093 W SE 0002093W WO 0132912 A8 WO0132912 A8 WO 0132912A8
Authority
WO
WIPO (PCT)
Prior art keywords
jak
cultured cells
tested compounds
trace
effects
Prior art date
Application number
PCT/SE2000/002093
Other languages
French (fr)
Other versions
WO2001032912A1 (en
Inventor
Gunnar Norstedt
Morales Amilcar Flores
Original Assignee
Sahltech Ab
Gunnar Norstedt
Morales Amilcar Flores
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sahltech Ab, Gunnar Norstedt, Morales Amilcar Flores filed Critical Sahltech Ab
Priority to CA002387147A priority Critical patent/CA2387147A1/en
Priority to AU14250/01A priority patent/AU1425001A/en
Priority to EP00976484A priority patent/EP1226268A1/en
Priority to JP2001535592A priority patent/JP2003513637A/en
Publication of WO2001032912A1 publication Critical patent/WO2001032912A1/en
Publication of WO2001032912A8 publication Critical patent/WO2001032912A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Abstract

The invention relates to the use of a JAK-STAT system in cultured cells to trace effects of biologically active entities on living organisms by monitoring any prolongation of the JAK-STAT signal as well as a method to trace said effects.
PCT/SE2000/002093 1999-11-01 2000-10-27 Use of the jak-stat system in cultured cells to trace effects of tested compounds WO2001032912A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002387147A CA2387147A1 (en) 1999-11-01 2000-10-27 New use of the jak-stat system
AU14250/01A AU1425001A (en) 1999-11-01 2000-10-27 New use of the jak-stat system
EP00976484A EP1226268A1 (en) 1999-11-01 2000-10-27 New use of the jak-stat system
JP2001535592A JP2003513637A (en) 1999-11-01 2000-10-27 New use of the JAK-STAT system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903953A SE9903953D0 (en) 1999-11-01 1999-11-01 New use of the jak-stat system
SE9903953-9 1999-11-01

Publications (2)

Publication Number Publication Date
WO2001032912A1 WO2001032912A1 (en) 2001-05-10
WO2001032912A8 true WO2001032912A8 (en) 2001-06-07

Family

ID=20417572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2000/002093 WO2001032912A1 (en) 1999-11-01 2000-10-27 Use of the jak-stat system in cultured cells to trace effects of tested compounds

Country Status (6)

Country Link
EP (1) EP1226268A1 (en)
JP (1) JP2003513637A (en)
AU (1) AU1425001A (en)
CA (1) CA2387147A1 (en)
SE (1) SE9903953D0 (en)
WO (1) WO2001032912A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527513A (en) * 2003-06-30 2007-09-27 ビオヴィトルム・アクチボラゲット Methods for identifying agents that modulate cytokines
CN112972492A (en) 2015-12-16 2021-06-18 沃尔特及伊莱萨霍尔医学研究院 Inhibition of cytokine-induced SH2 protein in NK cells
CN105802987A (en) * 2016-03-31 2016-07-27 江苏省农业科学院 Method for detecting fowl PRL based on JAK-STAT 5 signal transduction pathway

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814517A (en) * 1994-04-14 1998-09-29 Ligand Pharmaceuticals, Inc. DNA spacer regulatory elements responsive to cytokines and methods for their use
EP0755453A1 (en) * 1994-04-14 1997-01-29 Ligand Pharmaceuticals, Inc. Dna regulatory elements responsive to cytokines
AU2668699A (en) * 1998-02-11 1999-08-30 Beth Israel Deaconess Medical Center Methods and compositions for modulating leptin activity

Also Published As

Publication number Publication date
CA2387147A1 (en) 2001-05-10
WO2001032912A1 (en) 2001-05-10
JP2003513637A (en) 2003-04-15
AU1425001A (en) 2001-05-14
EP1226268A1 (en) 2002-07-31
SE9903953D0 (en) 1999-11-01

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