WO2001032866A3 - Hybrid adaptor receptors - Google Patents

Hybrid adaptor receptors Download PDF

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Publication number
WO2001032866A3
WO2001032866A3 PCT/GB2000/004189 GB0004189W WO0132866A3 WO 2001032866 A3 WO2001032866 A3 WO 2001032866A3 GB 0004189 W GB0004189 W GB 0004189W WO 0132866 A3 WO0132866 A3 WO 0132866A3
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WO
WIPO (PCT)
Prior art keywords
adaptor
receptors
proteins
receptor
intracellular signalling
Prior art date
Application number
PCT/GB2000/004189
Other languages
French (fr)
Other versions
WO2001032866A2 (en
Inventor
Helene Margaret Finney
Alastair David Griffith Lawson
Original Assignee
Celltech Chiroscience Ltd
Helene Margaret Finney
Alastair David Griffith Lawson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Chiroscience Ltd, Helene Margaret Finney, Alastair David Griffith Lawson filed Critical Celltech Chiroscience Ltd
Priority to JP2001535548A priority Critical patent/JP2003515321A/en
Priority to EP00973001A priority patent/EP1226245A2/en
Priority to AU11558/01A priority patent/AU1155801A/en
Publication of WO2001032866A2 publication Critical patent/WO2001032866A2/en
Publication of WO2001032866A3 publication Critical patent/WO2001032866A3/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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  • Health & Medical Sciences (AREA)
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Abstract

The present invention relates to chimeric receptor proteins, designated adaptor receptors, which use adaptor proteins as intracellular signalling components. By incorporating different adaptor proteins, optionally in conjunction with other cytoplasmic signalling sequences, as an intracellular signalling domain of an adaptor receptor, the level of intracellular signalling mediated by the adaptor receptor may be tailored as desired. Nucleic acids encoding adaptor receptors and adaptor receptor proteins, suitable for use in medicine, are described.
PCT/GB2000/004189 1999-11-01 2000-11-01 Hybrid adaptor receptors WO2001032866A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001535548A JP2003515321A (en) 1999-11-01 2000-11-01 Adapter receptor
EP00973001A EP1226245A2 (en) 1999-11-01 2000-11-01 Hybrid adaptor receptors
AU11558/01A AU1155801A (en) 1999-11-01 2000-11-01 Adaptor receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9925854.3 1999-11-01
GBGB9925854.3A GB9925854D0 (en) 1999-11-01 1999-11-01 Biological products

Publications (2)

Publication Number Publication Date
WO2001032866A2 WO2001032866A2 (en) 2001-05-10
WO2001032866A3 true WO2001032866A3 (en) 2001-11-01

Family

ID=10863769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004189 WO2001032866A2 (en) 1999-11-01 2000-11-01 Hybrid adaptor receptors

Country Status (5)

Country Link
EP (1) EP1226245A2 (en)
JP (1) JP2003515321A (en)
AU (1) AU1155801A (en)
GB (1) GB9925854D0 (en)
WO (1) WO2001032866A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12005081B2 (en) 2021-06-03 2024-06-11 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925853D0 (en) * 1999-11-01 1999-12-29 Celltech Therapeutics Ltd Biological products
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
JP6450690B2 (en) 2013-02-15 2019-01-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Chimeric antigen receptor and method of use thereof
SG11201804038VA (en) 2016-01-08 2018-06-28 Univ California Conditionally active heterodimeric polypeptides and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023613A2 (en) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Cell activation process and reagents therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023613A2 (en) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Cell activation process and reagents therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRUYNS E ET AL: "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 188, no. 3, 3 August 1998 (1998-08-03), pages 561 - 575, XP002090911, ISSN: 0022-1007 *
MARIE-CARDINE ANNE ET AL: "SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 189, no. 8, 19 April 1999 (1999-04-19), pages 1181 - 1194, XP002166555, ISSN: 0022-1007 *
TAKESHITA TOSHIKAZU ET AL: "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC. ORLANDO, FL,US, vol. 225, no. 3, 1996, pages 1035 - 1039, XP002162128, ISSN: 0006-291X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12005081B2 (en) 2021-06-03 2024-06-11 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof

Also Published As

Publication number Publication date
JP2003515321A (en) 2003-05-07
GB9925854D0 (en) 1999-12-29
WO2001032866A2 (en) 2001-05-10
AU1155801A (en) 2001-05-14
EP1226245A2 (en) 2002-07-31

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