WO2001030359A1 - Cholesterol lowering and blood lipids lowering composition - Google Patents
Cholesterol lowering and blood lipids lowering composition Download PDFInfo
- Publication number
- WO2001030359A1 WO2001030359A1 PCT/SE2000/002100 SE0002100W WO0130359A1 WO 2001030359 A1 WO2001030359 A1 WO 2001030359A1 SE 0002100 W SE0002100 W SE 0002100W WO 0130359 A1 WO0130359 A1 WO 0130359A1
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- Prior art keywords
- composition
- fatty acids
- lowering
- blood lipids
- esters
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 37
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims abstract description 24
- 239000008280 blood Substances 0.000 title claims abstract description 15
- 210000004369 blood Anatomy 0.000 title claims abstract description 15
- 150000002632 lipids Chemical class 0.000 title claims abstract description 14
- 235000012000 cholesterol Nutrition 0.000 title claims abstract description 12
- 235000013305 food Nutrition 0.000 claims abstract description 12
- 150000004666 short chain fatty acids Chemical class 0.000 claims abstract description 11
- 235000021391 short chain fatty acids Nutrition 0.000 claims abstract description 11
- 150000002148 esters Chemical class 0.000 claims abstract description 9
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 5
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 5
- 229940068065 phytosterols Drugs 0.000 claims abstract description 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims abstract description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229930182558 Sterol Natural products 0.000 claims description 12
- 150000003432 sterols Chemical class 0.000 claims description 12
- 235000003702 sterols Nutrition 0.000 claims description 12
- 235000019198 oils Nutrition 0.000 claims description 9
- 235000021323 fish oil Nutrition 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 5
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 235000012054 meals Nutrition 0.000 claims description 4
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 4
- LGJMUZUPVCAVPU-JFBKYFIKSA-N Sitostanol Natural products O[C@@H]1C[C@H]2[C@@](C)([C@@H]3[C@@H]([C@H]4[C@@](C)([C@@H]([C@@H](CC[C@H](C(C)C)CC)C)CC4)CC3)CC2)CC1 LGJMUZUPVCAVPU-JFBKYFIKSA-N 0.000 claims description 2
- 229940076810 beta sitosterol Drugs 0.000 claims description 2
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims description 2
- 229950005143 sitosterol Drugs 0.000 claims description 2
- LGJMUZUPVCAVPU-HRJGVYIJSA-N stigmastanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]2(C)CC1 LGJMUZUPVCAVPU-HRJGVYIJSA-N 0.000 claims description 2
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000002550 fecal effect Effects 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 230000003019 stabilising effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 235000013312 flour Nutrition 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 235000007319 Avena orientalis Nutrition 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 241000209761 Avena Species 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 244000075850 Avena orientalis Species 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical class CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- Phytosterols such as ⁇ -sitosterol and ⁇ -sitostanol and their derivatives are used in medicine
- Sterols and/or stanols are initially mixed with :.'. oil such as fish oil and esters of shorter fatty acids and glycerol.
- the mixture is transestcrificd in a known manner to mainly monoglycerides of fatty acids from fish oil or shorter fatty acids.
- the concentrate can be used such, be tabletted, encapsulated or mixed with food.
- the concentrate can also be mixed with hydroly ⁇ :! r :brcs in gel- or powder form.
- the mixture contains all desired components for blood lipids lowering and cholesterol lowering effects.
- the obtained mixture can be mixed into food such as bread, cakes, flakes and other or be encapsulated or tabletted.
- the advantages besides the pure biological are that the oxygene sensitive polyunsaturated fatty acids are ⁇ tabilsed by the hydrolysed meal.
- the manufacturing process is simple and cheap. For different applications one or more of the
- the mixture can be kept under inert athmosph ⁇ re.
- the obtained composition can be used as is or be mixed into various food.
- EXAMPLE 2 50g of oil containing polyunsaturated fatty aA'.s, 25 g of oils from short chain fatty acids, 18 g of glycerol and 40 g of sterols are mixed in v. vessel under inert athmosphere and are transesterified at elevated temperatures in k'-.c.vn way. After cooling to 50-80 °C the mixture
- the obtained composition is added to 2500 g of a gel based on hydrolysed oats fibre under good stirring.
- the obtained composition can be used as is or be mixed into into various food.
- the obtained composition can be used as is or mixed into various food.
- EXAMPLE 4 500 g of fish oil, 100 g of oil of short chain fatty acids, 150 g of glycerol and 300 g of sterols
- composition 65 g of oils of short chain fatty acids, 18 g of glycerol and 40 g of sterols are mixed in a vessel under inert athmosphere and transesterified at elevated temperature in known way. After cooling to 50-80 °C the mixture is added under good stirring to 400 g of gel based on hydrolysed oats fibre.
- the obtained composition can be used as is, be encapsulated, tabletted
- EXAMPLE 6 40 g of sterols are dissolved in 50 g offish oil and 40 g of a inonoglyceride in a vessel under inert athmosphere at 100 °C.
- the composition obtained can be used as is, be encapsulated, tabletted or mixed into different food.
- sterols 50 g are mixed with 65 g of oils of short chain fatty acids and 15 g of glycerol and
- the obtained composition can be used as is, be
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
Abstract
The present invention is a composition containing cholesterol lowering and blood lipids lowering components such as phytosterols in a biologically easily available form in combination with unsaturated fatty acids or esters, short chain fatty acids or esters and/or hydrolyzed flour containing β-glucan and amylodextrin; food containing such a composition and a method for manufacturing of such a composition.
Description
Patent application no 9903915-8 Cholesterol lowering and blood lipids lowering
composition. Priority date Octobe.29,1999.
CHOLESTEROL LOWERING AND BLOODL1P1DS LOWERING COMPOSITION
BACKGROUND
Phytosterols such as β-sitosterol and β-sitostanol and their derivatives are used in medicine
owing to their ability to lower total and LDL- cholesterol levels in blood. Recent research has shown that n-3 polyunsatiiratcd fatty acids present in fish oils such as eicosapentaenic acids (EPA) and docosahexaenic acids (DHA) positively effect our blood lipids (1 ). They are also building blocks in prostaglandins Further a positive effect on blood lipids has been noted by intake of shorter fatty acids (2) Finally, the importance of a daily
intake of β-glucan and amylodextrins is recommended by USDA. (3,4). These compounds
can be recovered by hydrolysis of oat meal and can be made in gelform as hydrocolloids
DESCRIPTION OF THE INVENTION In the present invention is shown how sterols and/or stanols in a biologially easily available
form has sucessfully been combined with other blood lipids lowering and cholesterol lowering
compounds such as unsaturated fatty acids or their derivatives and/ or shorter fatty acids or
derivatives of these and/or hydrolyscd fibres containing β-glucan or amylodextrines. A clear
distinction between blood lipids lowering and cholesterol lowering action of these compound is not present, furthermore interactive effects may occur.
Sterols and/or stanols are initially mixed with :.'. oil such as fish oil and esters of shorter fatty acids and glycerol. The mixture is transestcrificd in a known manner to mainly monoglycerides of fatty acids from fish oil or shorter fatty acids. In this way we obtain in only one process step an entirely new combination of cholesterol lowering sterols and or stanols and good fatty acids in a concentrate, in some cases in the same molecule. The concentrate can be used such, be tabletted, encapsulated or mixed with food. The concentrate can also be mixed with hydrolyε :! r:brcs in gel- or powder form. The obtained
mixture contains all desired components for blood lipids lowering and cholesterol lowering effects. The obtained mixture can be mixed into food such as bread, cakes, flakes and other or be encapsulated or tabletted.. The advantages besides the pure biological are that the oxygene sensitive polyunsaturated fatty acids are εtabilsed by the hydrolysed meal. The manufacturing process is simple and cheap. For different applications one or more of the
components can be excluded. The present invention will be described below by non limiting
examples.
EXAMPLE 1
55 g of fishoil, 25 g of short chain fatty acids, 18 g of glycerol and 40 g of sterols are mixed
in a vessel under inert athmosphere and are tπv.'ε slerified at elevated temperatures in known way. After cooling to 50-80 °C the mixture is r .lAd to 400 g of a gel based on hydrolysed
SUBSTlTUTl SHEET (RULE 26)
meal under good stirring. If desired stabilisers for unsaturated fatty acids can be added and/or
the mixture can be kept under inert athmosphεre.
The obtained composition can be used as is or be mixed into various food.
EXAMPLE 2 50g of oil containing polyunsaturated fatty aA'.s, 25 g of oils from short chain fatty acids, 18 g of glycerol and 40 g of sterols are mixed in v. vessel under inert athmosphere and are transesterified at elevated temperatures in k'-.c.vn way. After cooling to 50-80 °C the mixture
is added to 2500 g of a gel based on hydrolysed oats fibre under good stirring. The obtained composition can be used as is or be mixed into into various food.
EXAMPLE 3
55 g of an oil containing polyunsaturated fatty acids, 10 g of glycerol and 40 g of sterols are
transesterified in known way as in example 1. After cooling to 50-80 °C the mixture is added to 400 g of a gel based on hydrolysed oats fibre under good stirring.
The obtained composition can be used as is or mixed into various food.
EXAMPLE 4 500 g of fish oil, 100 g of oil of short chain fatty acids, 150 g of glycerol and 300 g of sterols
transesterified as in ex 1 The composition obtained can be used as such or mixed into different food, be encapsulated or tabletted.
EXAMPLE 5
65 g of oils of short chain fatty acids, 18 g of glycerol and 40 g of sterols are mixed in a vessel under inert athmosphere and transesterified at elevated temperature in known way. After cooling to 50-80 °C the mixture is added under good stirring to 400 g of gel based on hydrolysed oats fibre. The obtained composition can be used as is, be encapsulated, tabletted
or mixed into different food.
EXAMPLE 6 40 g of sterols are dissolved in 50 g offish oil and 40 g of a inonoglyceride in a vessel under inert athmosphere at 100 °C. The composition obtained can be used as is, be encapsulated, tabletted or mixed into different food.
EXAMPLE 7
50 g of sterols are mixed with 65 g of oils of short chain fatty acids and 15 g of glycerol and
the mixture is transesterified as in ex 1. The obtained composition can be used as is, be
encapsulated, tabletted or mixed into different food.
EXAMPLE 8
20g of sterols are dissolved in 40g of monoglycerides at 85°C and added to 200g of gelbased hydrolysed oats fibre under good stirring. The composition obtained can beused as is, been
capsulated, tabletted or mixed into various food.
Claims
1. A composition containing cholesterol lowering and blood lipids lowering components in which phytosterols, mixed with esters of unsaturated fatty acids and/or esters of short chain fatty acids, are distributed in monomolecular, low associated or cluster form in hydrolysed
fibres containing β-glucan and amylodext ines.
2. A composition as in claim 1 in which the cholesterol lowering component contains
β-sitosterol and/or β-sitostanol.
3. A composition as in claim 1 in which the cholesterol lowering composition contains
β-sitosteryl esters and/or β-sitostanyl esters of polyunsaturated fatty acids.
4. A composition as in claim 1 in which the cholsterol lowering component contains
β-sitosteryl esters and/or β-sitostanyl esters of short chain fatty acids.
5. A composition as in claim 1 in which the blood lipids lowering component contains fish
oil and /or mono and diglycerides of polyunsaturated fatty acids.
6. A composition as in claim 1 in which the blood lipids lowering component contains tri-
and/or mono- and diglycerides of short chain fatty acids.
7. A composition as in claim 1 in which the blood lipids lowering component contains a
mixture offish oil and triglycerides of short chain fatty acids.
8. A composition as in claim 1 in which the blood lipids lowering and stabilising component
contains hydrolysed meal containing a soluble fibre such as β-glucan or amylodextrins.
9. Method to prepare a composition as in the claims 1 -8 in which fish oil and/or triglycerides
of short chain fatty acids are mixed with glycerol and phytosterols, transesterified at elevated temperatures at 130 - 230 °C and that the mixture obtained is spread and stabilised in a gel based on hydrolysed fibres.
10. Food containing a composition as in the claims 1 -8 in a suitable amount for a cholesterol and blood lipids lowering effect.
11. Capsule or tablet containing a composition as in claims 1-8.
REFERENCES
1. Bartram, H.P.; Gostner, A. et al. Effect of dietaiy fish oil on fecal bile acid and neutral sterol excredon in healthy volunteers. Z. Ernaehrungsv.,iss. (1998), 37(Supl. 1), 139-
141
2. Inglett,G.E.; Newrnan.R.K. Plant Foods Hum. Nutr. 1994, 45,53-61
3. Anderson, James W.; Smith, Belinda M.; Gustafson, Nansy J. Am. J. Clin. Nutr. 1994, 59(5, Suppi.), 1242-1247
4. Inglett, George E. Nutraceuticals: The key to healthier eating ChemTech. 1999, October, 38-42.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00975114A EP1227816A1 (en) | 1999-10-29 | 2000-10-27 | Cholesterol lowering and blood lipids lowering composition |
| AU13211/01A AU1321101A (en) | 1999-10-29 | 2000-10-27 | Cholesterol lowering and blood lipids lowering composition |
| US10/111,614 US7785620B1 (en) | 1999-10-29 | 2000-10-27 | Cholesterol lowering and blood lipids lowering composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903915-8 | 1999-10-29 | ||
| SE9903915A SE517769C2 (en) | 1999-10-29 | 1999-10-29 | Cholesterol and blood fat lowering composition, containing phytosterols, mixed with monoglycerides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001030359A1 true WO2001030359A1 (en) | 2001-05-03 |
Family
ID=20417537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/SE2000/002100 WO2001030359A1 (en) | 1999-10-29 | 2000-10-27 | Cholesterol lowering and blood lipids lowering composition |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7785620B1 (en) |
| EP (1) | EP1227816A1 (en) |
| AU (1) | AU1321101A (en) |
| SE (1) | SE517769C2 (en) |
| WO (1) | WO2001030359A1 (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002082929A1 (en) * | 2001-04-12 | 2002-10-24 | Raisio Benecol Oy | Improved edible compositions for lowering cholesterol |
| EP1361264A1 (en) * | 2001-02-15 | 2003-11-12 | Asahi Denka Kogyo Kabushiki Kaisha | PRODUCTS CONTAINING $G(b)-GLUCAN |
| WO2004009093A1 (en) * | 2002-07-23 | 2004-01-29 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Cholesterol-reducing agent made of dietary fibre and cholesterol-reducing substances |
| EP1600062A1 (en) * | 2004-05-25 | 2005-11-30 | Cognis IP Management GmbH | Oral and/or topical compositions comprising prebiotics and sterols |
| EP1600060A1 (en) * | 2004-05-25 | 2005-11-30 | Cognis IP Management GmbH | Oral and/or topical compositions comprising prebiotics and fatty acid |
| EP1614357A1 (en) * | 2004-07-10 | 2006-01-11 | Cognis IP Management GmbH | Dietary supplements comprising prebiotics and fatty acid |
| EP1983989A1 (en) * | 2006-02-09 | 2008-10-29 | National Research Council of Canada | Combinations of botanical extracts for promoting cardiovascular health |
| US7732000B2 (en) * | 2002-06-20 | 2010-06-08 | General Mills, Inc. | Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix |
| IT201800002663A1 (en) * | 2018-02-13 | 2019-08-13 | Ciro Langella | MULTIFUNCTIONAL COMPLEX FOR THE PRODUCTION OF FOOD NUTRACEUTICS, DRUGS OR COSMETICS |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6115647A (en) * | 1984-06-30 | 1986-01-23 | Asahi Denka Kogyo Kk | Oil and fat food |
| WO1992019640A1 (en) * | 1991-05-03 | 1992-11-12 | Raision Margariini Oy | A substance for lowering high cholesterol level in serum and a method for preparing the same |
| WO1999015546A1 (en) * | 1997-09-09 | 1999-04-01 | Raisio Benecol Ltd. | Use of organic acid esters in dietary fat |
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| EP0756828B2 (en) * | 1995-08-04 | 2010-09-22 | N.V. Nutricia | Nutritional composition containing fibres |
| US5883273A (en) * | 1996-01-26 | 1999-03-16 | Abbott Laboratories | Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds |
| US6423363B1 (en) | 1997-08-22 | 2002-07-23 | Lipton, Division Of Conopco, Inc. | Aqueous dispersion |
| ES2222553T3 (en) | 1997-08-22 | 2005-02-01 | Unilever N.V. | FAT-BASED FOOD PRODUCT THAT INCLUDES STEROLS. |
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| CN1267030C (en) | 1998-03-24 | 2006-08-02 | 花王株式会社 | Beverage products |
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- 1999-10-29 SE SE9903915A patent/SE517769C2/en not_active IP Right Cessation
-
2000
- 2000-10-27 AU AU13211/01A patent/AU1321101A/en not_active Abandoned
- 2000-10-27 WO PCT/SE2000/002100 patent/WO2001030359A1/en not_active Application Discontinuation
- 2000-10-27 US US10/111,614 patent/US7785620B1/en not_active Expired - Fee Related
- 2000-10-27 EP EP00975114A patent/EP1227816A1/en active Pending
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| JPS6115647A (en) * | 1984-06-30 | 1986-01-23 | Asahi Denka Kogyo Kk | Oil and fat food |
| WO1992019640A1 (en) * | 1991-05-03 | 1992-11-12 | Raision Margariini Oy | A substance for lowering high cholesterol level in serum and a method for preparing the same |
| WO1999015546A1 (en) * | 1997-09-09 | 1999-04-01 | Raisio Benecol Ltd. | Use of organic acid esters in dietary fat |
| WO1999025362A1 (en) * | 1997-11-14 | 1999-05-27 | Cognis Deutschland Gmbh | Use of mixtures of active agents containing phytostenol for producing hypocholesteraemic preparations |
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| GEORGE E. INGLETT: "Nutraceuticals; The key to healthier eating. Grandma was right about eating your porridge. Three new fat substitutes provide safe and functional alternatives to fat additives in foods", CHEMTECH, October 1999 (1999-10-01), pages 38 - 42, XP002937207 * |
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Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002233639B2 (en) * | 2001-02-15 | 2007-03-01 | Adeka Corporation | Products containing $G(b)-glucan |
| EP1361264A1 (en) * | 2001-02-15 | 2003-11-12 | Asahi Denka Kogyo Kabushiki Kaisha | PRODUCTS CONTAINING $G(b)-GLUCAN |
| EP1361264A4 (en) * | 2001-02-15 | 2005-03-16 | Asahi Denka Kogyo Kk | PRODUCTS CONTAINING $G(b)-GLUCAN |
| US8414913B2 (en) | 2001-04-12 | 2013-04-09 | Raisio Benecol Oy | Edible compositions for lowering cholesterol |
| WO2002082929A1 (en) * | 2001-04-12 | 2002-10-24 | Raisio Benecol Oy | Improved edible compositions for lowering cholesterol |
| US7794745B2 (en) | 2001-04-12 | 2010-09-14 | Raisio Nutrition Ltd. | Edible compositions for lowering cholesterol |
| US8168248B2 (en) | 2002-06-20 | 2012-05-01 | General Mills, Inc. | Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix |
| US7732000B2 (en) * | 2002-06-20 | 2010-06-08 | General Mills, Inc. | Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix |
| WO2004009093A1 (en) * | 2002-07-23 | 2004-01-29 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Cholesterol-reducing agent made of dietary fibre and cholesterol-reducing substances |
| EP1600060A1 (en) * | 2004-05-25 | 2005-11-30 | Cognis IP Management GmbH | Oral and/or topical compositions comprising prebiotics and fatty acid |
| WO2005115172A1 (en) * | 2004-05-25 | 2005-12-08 | Cognis Ip Management Gmbh | Oral and/or topical compositions comprising prebiotics and fatty acid |
| WO2005115171A1 (en) * | 2004-05-25 | 2005-12-08 | Cognis Ip Management Gmbh | Oral and/or topical compositions comprising prebiotics and sterols |
| US8329672B2 (en) | 2004-05-25 | 2012-12-11 | Cognis Ip Management Gmbh | Oral and/or topical compositions comprising prebiotics and fatty acid |
| EP1600062A1 (en) * | 2004-05-25 | 2005-11-30 | Cognis IP Management GmbH | Oral and/or topical compositions comprising prebiotics and sterols |
| WO2006005464A3 (en) * | 2004-07-10 | 2006-05-04 | Cognis Ip Man Gmbh | Dietary supplements comprising prebiotics and fatty acid |
| WO2006005464A2 (en) * | 2004-07-10 | 2006-01-19 | Cognis Ip Management Gmbh | Dietary supplements comprising prebiotics and fatty acid |
| EP1614357A1 (en) * | 2004-07-10 | 2006-01-11 | Cognis IP Management GmbH | Dietary supplements comprising prebiotics and fatty acid |
| EP1983989A1 (en) * | 2006-02-09 | 2008-10-29 | National Research Council of Canada | Combinations of botanical extracts for promoting cardiovascular health |
| EP1983989A4 (en) * | 2006-02-09 | 2009-07-08 | Ca Nat Research Council | Combinations of botanical extracts for promoting cardiovascular health |
| JP2009525990A (en) * | 2006-02-09 | 2009-07-16 | ナショナル・リサーチ・カウンシル・オブ・カナダ | Pharmaceutical composition |
| US8895079B2 (en) | 2006-02-09 | 2014-11-25 | National Research Council Of Canada | Combinations of botanical extracts for promoting cardiovascular health |
| IT201800002663A1 (en) * | 2018-02-13 | 2019-08-13 | Ciro Langella | MULTIFUNCTIONAL COMPLEX FOR THE PRODUCTION OF FOOD NUTRACEUTICS, DRUGS OR COSMETICS |
Also Published As
| Publication number | Publication date |
|---|---|
| SE9903915D0 (en) | 1999-10-29 |
| SE517769C2 (en) | 2002-07-16 |
| US7785620B1 (en) | 2010-08-31 |
| EP1227816A1 (en) | 2002-08-07 |
| AU1321101A (en) | 2001-05-08 |
| SE9903915L (en) | 2001-04-30 |
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