WO2001029050A3 - Condensed pyrrole derivatives as neuraminidase inhibitors - Google Patents

Condensed pyrrole derivatives as neuraminidase inhibitors Download PDF

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Publication number
WO2001029050A3
WO2001029050A3 PCT/US2000/026071 US0026071W WO0129050A3 WO 2001029050 A3 WO2001029050 A3 WO 2001029050A3 US 0026071 W US0026071 W US 0026071W WO 0129050 A3 WO0129050 A3 WO 0129050A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuraminidase
compounds
pyrrole derivatives
neuraminidase inhibitors
condensed pyrrole
Prior art date
Application number
PCT/US2000/026071
Other languages
French (fr)
Other versions
WO2001029050A2 (en
Inventor
Clarence J Maring
David A Degoey
William J Flosi
Vincent L Giranda
Dale J Kempf
April Kennedy
Larry L Klein
Allan C Krueger
Keith F Mcdaniel
Vincent S Stoll
Minghua Sun
Chen Zhao
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to AU78312/00A priority Critical patent/AU7831200A/en
Publication of WO2001029050A2 publication Critical patent/WO2001029050A2/en
Publication of WO2001029050A3 publication Critical patent/WO2001029050A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The instant invention provides compounds of formula (I) or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.
PCT/US2000/026071 1999-10-19 2000-09-22 Condensed pyrrole derivatives as neuraminidase inhibitors WO2001029050A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU78312/00A AU7831200A (en) 1999-10-19 2000-09-22 Neuraminidase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41986899A 1999-10-19 1999-10-19
US09/419,868 1999-10-19
US42802199A 1999-10-27 1999-10-27
US09/428,021 1999-10-27

Publications (2)

Publication Number Publication Date
WO2001029050A2 WO2001029050A2 (en) 2001-04-26
WO2001029050A3 true WO2001029050A3 (en) 2001-11-22

Family

ID=27024654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026071 WO2001029050A2 (en) 1999-10-19 2000-09-22 Condensed pyrrole derivatives as neuraminidase inhibitors

Country Status (2)

Country Link
AU (1) AU7831200A (en)
WO (1) WO2001029050A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558321A1 (en) * 1992-02-27 1993-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. Antivirally active N-cycloalkyl alkanol compounds
US5962467A (en) * 1995-06-07 1999-10-05 Glycodesign, Inc. Derivatives of swainsonine and their use as therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558321A1 (en) * 1992-02-27 1993-09-01 Sanwa Kagaku Kenkyusho Co., Ltd. Antivirally active N-cycloalkyl alkanol compounds
US5962467A (en) * 1995-06-07 1999-10-05 Glycodesign, Inc. Derivatives of swainsonine and their use as therapeutic agents

Also Published As

Publication number Publication date
WO2001029050A2 (en) 2001-04-26
AU7831200A (en) 2001-04-30

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