WO2001028574A3 - Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau - Google Patents

Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau Download PDF

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Publication number
WO2001028574A3
WO2001028574A3 PCT/US2000/041365 US0041365W WO0128574A3 WO 2001028574 A3 WO2001028574 A3 WO 2001028574A3 US 0041365 W US0041365 W US 0041365W WO 0128574 A3 WO0128574 A3 WO 0128574A3
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WO
WIPO (PCT)
Prior art keywords
brain
inducing
progenitor cells
migration
methods
Prior art date
Application number
PCT/US2000/041365
Other languages
English (en)
Other versions
WO2001028574A2 (fr
Inventor
Rosemary A Fricker
Original Assignee
Stem Cells Inc
Rosemary A Fricker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stem Cells Inc, Rosemary A Fricker filed Critical Stem Cells Inc
Priority to EP00984586A priority Critical patent/EP1227823A2/fr
Priority to AU21185/01A priority patent/AU2118501A/en
Priority to JP2001531403A priority patent/JP2003512333A/ja
Priority to CA002387748A priority patent/CA2387748A1/fr
Publication of WO2001028574A2 publication Critical patent/WO2001028574A2/fr
Publication of WO2001028574A3 publication Critical patent/WO2001028574A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés d'induction de la migration et de la prolifération in vivo de cellules progénitrices transplantées dans le cerveau. L'invention concerne également l'isolement, la caractérisation, la prolifération, la différenciation et la transplantation des cellules souches neuronales mammaliennes.
PCT/US2000/041365 1999-10-20 2000-10-20 Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau WO2001028574A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00984586A EP1227823A2 (fr) 1999-10-20 2000-10-20 Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau
AU21185/01A AU2118501A (en) 1999-10-20 2000-10-20 Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
JP2001531403A JP2003512333A (ja) 1999-10-20 2000-10-20 脳における移植された前駆体細胞のインビボ増殖および移動を誘導するための方法
CA002387748A CA2387748A1 (fr) 1999-10-20 2000-10-20 Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16055399P 1999-10-20 1999-10-20
US60/160,553 1999-10-20

Publications (2)

Publication Number Publication Date
WO2001028574A2 WO2001028574A2 (fr) 2001-04-26
WO2001028574A3 true WO2001028574A3 (fr) 2001-11-08

Family

ID=22577363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041365 WO2001028574A2 (fr) 1999-10-20 2000-10-20 Procedes d'induction de la proliferation et la migration in vivo de cellules progenitrices transplantees dans le cerveau

Country Status (5)

Country Link
EP (1) EP1227823A2 (fr)
JP (1) JP2003512333A (fr)
AU (1) AU2118501A (fr)
CA (1) CA2387748A1 (fr)
WO (1) WO2001028574A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048934B2 (en) 2001-08-30 2006-05-23 Stem Cell Therapeutics Inc. Combined regulation of neural cell production
CA2492434A1 (fr) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Procede permettant d'accroitre et/ou d'induire une migration neuronale au moyen de l'erythropoietine
GB0222846D0 (en) * 2002-10-03 2002-11-06 Choo Yen Cell culture
ES2392282T3 (es) 2004-02-13 2012-12-07 Stem Cell Therapeutics Corp. Uso de la hormona luteinizante (LH) y de la gonadotropina coriónica (hCG) para la proliferación de células precursoras neurales y la neurogénesis
KR20080074108A (ko) 2005-09-27 2008-08-12 스템 셀 테라퓨틱스 코포레이션 프로락틴에 의해 조절되는 올리고덴드로사이트 전구체 세포증식
CA2723382A1 (fr) * 2008-05-08 2009-11-12 University Of Rochester Traitement des maladies de la myeline au moyen de preparations cellulaires optimisees
CN110713982A (zh) * 2019-11-25 2020-01-21 深圳科学之门生物工程有限公司 一种用于神经干细胞快速扩增的培养基

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
WO1999006060A1 (fr) * 1997-08-04 1999-02-11 The Regents Of The University Of California Procede de traitement des deficits neurologiques
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
WO1999006060A1 (fr) * 1997-08-04 1999-02-11 The Regents Of The University Of California Procede de traitement des deficits neurologiques
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRAIG CONSTANCE G ET AL: "In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain.", JOURNAL OF NEUROSCIENCE, vol. 16, no. 8, 1996, pages 2649 - 2658, XP001002077, ISSN: 0270-6474 *
FRICKER-GATES ROSEMARY A ET AL: "EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum.", EXPERIMENTAL NEUROLOGY, vol. 165, no. 2, October 2000 (2000-10-01), pages 237 - 247, XP002167679, ISSN: 0014-4886 *
WINKLER C ET AL: "Effects of intraventricular EGF-delivery on transplants of EGF-responsive neural progenitor cells.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 1997, 27th Annual Meeting of the Society for Neuroscience, Part 1;New Orleans, Louisiana, USA; October 25-30, 1997, pages 593, XP001002082, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
EP1227823A2 (fr) 2002-08-07
CA2387748A1 (fr) 2001-04-26
JP2003512333A (ja) 2003-04-02
WO2001028574A2 (fr) 2001-04-26
AU2118501A (en) 2001-04-30

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