WO2001027137A3 - Rattus norvegicus (edg3) - Google Patents

Rattus norvegicus (edg3) Download PDF

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Publication number
WO2001027137A3
WO2001027137A3 PCT/US2000/028231 US0028231W WO0127137A3 WO 2001027137 A3 WO2001027137 A3 WO 2001027137A3 US 0028231 W US0028231 W US 0028231W WO 0127137 A3 WO0127137 A3 WO 0127137A3
Authority
WO
WIPO (PCT)
Prior art keywords
edg3
rattus norvegicus
hiv
asthma
polypeptides
Prior art date
Application number
PCT/US2000/028231
Other languages
French (fr)
Other versions
WO2001027137A2 (en
Inventor
Pamela Lane
Ping Tsui
Nabil Elshourbagy
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc filed Critical Smithkline Beecham Corp
Publication of WO2001027137A2 publication Critical patent/WO2001027137A2/en
Publication of WO2001027137A3 publication Critical patent/WO2001027137A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Abstract

Rattus norvegicus EDG3 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Rattus norvegicus EDG3. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers, asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles de la Tourett's syndrome.
PCT/US2000/028231 1999-10-12 2000-10-12 Rattus norvegicus (edg3) WO2001027137A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15901999P 1999-10-12 1999-10-12
US60/159,019 1999-10-12
US68610500A 2000-10-11 2000-10-11
US09/686,105 2000-10-11

Publications (2)

Publication Number Publication Date
WO2001027137A2 WO2001027137A2 (en) 2001-04-19
WO2001027137A3 true WO2001027137A3 (en) 2001-06-07

Family

ID=26855585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028231 WO2001027137A2 (en) 1999-10-12 2000-10-12 Rattus norvegicus (edg3)

Country Status (1)

Country Link
WO (1) WO2001027137A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003297232B2 (en) 2002-12-20 2010-02-04 Merck Sharp & Dohme Corp. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912144A (en) * 1997-04-24 1999-06-15 Incyte Pharmaceuticals, Inc. Edg-1-receptor homolog
US6130067A (en) * 1998-05-20 2000-10-10 Smithkline Beecham Corporation Human EDG3sb gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912144A (en) * 1997-04-24 1999-06-15 Incyte Pharmaceuticals, Inc. Edg-1-receptor homolog
US6130067A (en) * 1998-05-20 2000-10-10 Smithkline Beecham Corporation Human EDG3sb gene

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 26 September 1999 (1999-09-26), NAKAJIMA N. ET AL., Database accession no. AF184914 *
DATABASE GENBANK [online] 27 November 1997 (1997-11-27), MARRIA M. ET AL., Database accession no. AA672296 *
DATABASE GENBANK [online] 8 September 1998 (1998-09-08), MARRA M. ET AL., Database accession no. AI115954 *
ZHANG G. ET AL.: "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1- phosphate", GENE, vol. 227, February 1999 (1999-02-01), pages 89 - 99 *

Also Published As

Publication number Publication date
WO2001027137A2 (en) 2001-04-19

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