WO2001023620A3 - Arrays with modified oligonucleotide and polynucleotide compositions - Google Patents

Arrays with modified oligonucleotide and polynucleotide compositions Download PDF

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Publication number
WO2001023620A3
WO2001023620A3 PCT/US2000/026989 US0026989W WO0123620A3 WO 2001023620 A3 WO2001023620 A3 WO 2001023620A3 US 0026989 W US0026989 W US 0026989W WO 0123620 A3 WO0123620 A3 WO 0123620A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
modified oligonucleotide
polynucleotide compositions
array
nucleic acids
Prior art date
Application number
PCT/US2000/026989
Other languages
French (fr)
Other versions
WO2001023620A2 (en
Inventor
Roderic M K Dale
Original Assignee
Oligos Etc Inc
Roderic M K Dale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/408,761 external-priority patent/US6844151B1/en
Priority claimed from US09/524,092 external-priority patent/US6562569B1/en
Application filed by Oligos Etc Inc, Roderic M K Dale filed Critical Oligos Etc Inc
Priority to AU77421/00A priority Critical patent/AU7742100A/en
Publication of WO2001023620A2 publication Critical patent/WO2001023620A2/en
Publication of WO2001023620A3 publication Critical patent/WO2001023620A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Abstract

The present invention provides arrays having associated modified polynucleotides, e.g., oligonucleotides that selectively bind to DNA or RNA, methods of making such arrays, assays for using such arrays, and the like. In one embodiment, the associated nucleic acids of the array of the invention exhibit substantial acid resistance, allowing the arrays to be treated with low pH solutions. In another embodiment, the modified associated nucleic acids of the array of the invention exhibit substantial resistance to nuclease degradation.
PCT/US2000/026989 1999-09-29 2000-09-28 Arrays with modified oligonucleotide and polynucleotide compositions WO2001023620A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU77421/00A AU7742100A (en) 1999-09-29 2000-09-28 Arrays with modified oligonucleotide and polynucleotide compositions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/408,761 US6844151B1 (en) 1999-09-29 1999-09-29 Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
US09/408,761 1999-09-29
US09/524,092 US6562569B1 (en) 1998-12-30 2000-03-13 Arrays with modified oligonucleotide and polynucleotide compositions
US09/524,092 2000-03-13
US09/528,404 US6440723B1 (en) 1998-12-30 2000-03-17 Arrays with modified oligonucleotide and polynucleotide compositions
US09/528,404 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001023620A2 WO2001023620A2 (en) 2001-04-05
WO2001023620A3 true WO2001023620A3 (en) 2001-10-18

Family

ID=27410771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026989 WO2001023620A2 (en) 1999-09-29 2000-09-28 Arrays with modified oligonucleotide and polynucleotide compositions

Country Status (2)

Country Link
AU (1) AU7742100A (en)
WO (1) WO2001023620A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1414841B1 (en) 2001-07-10 2012-11-14 Lakewood-Amedex, Inc Oligonucleotide-containing pharmacological compositions and their use
CN100341570C (en) * 2003-03-31 2007-10-10 穆海东 Preparation method of protein chip
WO2021026040A1 (en) * 2019-08-02 2021-02-11 Shield Diagnostics Corp. Sequence specific nucleic acid enrichment methods and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0742287A2 (en) * 1995-05-10 1996-11-13 McGall, Glenn H. Modified nucleic acid probes
WO1998000564A1 (en) * 1993-07-20 1998-01-08 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of rna by 2'-5' oligonucleotides
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
WO1998013526A1 (en) * 1996-09-26 1998-04-02 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998039348A1 (en) * 1997-03-05 1998-09-11 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
WO2000040525A2 (en) * 1998-12-30 2000-07-13 Oligos Etc. Inc. Polymer arrays and methods of making and using same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
WO1998000564A1 (en) * 1993-07-20 1998-01-08 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of rna by 2'-5' oligonucleotides
EP0742287A2 (en) * 1995-05-10 1996-11-13 McGall, Glenn H. Modified nucleic acid probes
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
WO1998013526A1 (en) * 1996-09-26 1998-04-02 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998039348A1 (en) * 1997-03-05 1998-09-11 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
WO2000040525A2 (en) * 1998-12-30 2000-07-13 Oligos Etc. Inc. Polymer arrays and methods of making and using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CUMMINS L L ET AL: "CHARACTERIZATION OF FULLY 2'-MODIFIED OLIGORIBONUCLEOTIDE HETERO- AND HOMODUPLEX HYBRIDIZATION AND NUCLEASE SENSITIVITY", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 23, no. 11, 11 June 1995 (1995-06-11), pages 2019 - 2024, XP002048574, ISSN: 0305-1048 *
MOODY H M ET AL: "REGIOSPECIFIC INHIBITION OF DNA DUPLICATION BY ANTISENSE PHOSPHATE-METHYLATED OLIGODEOXYNUCLEOTIDES", NUCLEIC ACIDS RESEARCH, vol. 17, no. 12, 1989, pages 4769 - 4782, XP002166143, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2001023620A2 (en) 2001-04-05
AU7742100A (en) 2001-04-30

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